Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/6699 |
Resumo: | p.66-68 |
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Andrade, Luis Jesuino de OliveiraMelo, Paulo Roberto Santana deAtta, Ajax MercêsAtta, Maria Luiza Brito de SousaJesus, Larissa Santana deSousa, Gabriel Menezes deSilva, Carolina Alves CostaParaná, RaymundoAndrade, Luis Jesuino de OliveiraMelo, Paulo Roberto Santana deAtta, Ajax MercêsAtta, Maria Luiza Brito de SousaJesus, Larissa Santana deSousa, Gabriel Menezes deSilva, Carolina Alves CostaParaná, Raymundo2012-09-06T11:47:05Z2012-09-06T11:47:05Z2011-011413-8670http://www.repositorio.ufba.br/ri/handle/ri/6699v. 15, n. 1p.66-68Cryoglobulinemia and non-organ-specific-autoantibody are biomarkers of autoimmunity of the chronic infection caused by hepatitis C virus (HCV). In this work, we report the association between the presence of smooth muscle antibodies (SMA) and cryoglobulinemia and chronic liver disease in HCV carriers. Sixty-five untreated HCV patients, 38 women and 27 men were included in this study. Cryoglobulinemia was tested by cryoprecipitation, SMA by indirect fluorescent antibody test, and liver fibrosis and hepatocellular inflammation activity was investigated by histology of liver biopsy using the METAVIR score. The prevalence of SMA in the patients was 33.8% and cryoglobulinemia was demonstrated in 36.9% patients. Cryoglobulinemia and SMA seropositivity was associated with advanced fibrosis (p < 0.05). The presence of SMA and cryoglobulinemia was not associated with hepatocellular inflammation activity, age, carrier gender or HCV genotype. We concluded that liver biopsy should be recommended for HCV carriers that are seropositive for SMA or cryoglobulinemia.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-09-06T11:47:05Z No. of bitstreams: 1 Andrade, Luis Jesuino de Oliveira (2).pdf: 759994 bytes, checksum: 0f33616384771ef67c98e883631a590a (MD5)Made available in DSpace on 2012-09-06T11:47:05Z (GMT). No. of bitstreams: 1 Andrade, Luis Jesuino de Oliveira (2).pdf: 759994 bytes, checksum: 0f33616384771ef67c98e883631a590a (MD5) Previous issue date: 2011-01SalvadorThe Brazilian Journal of Infectious Diseases and Contexto Publishinghttp://dx.doi.org/10.1590/S1413-86702011000100012reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHepatitis CMuscleSmoothAntibody specificityCryoglobulinsLiver diseasesSmooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriersBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALAndrade, Luis Jesuino de Oliveira (2).pdfAndrade, Luis Jesuino de Oliveira (2).pdfapplication/pdf759994https://repositorio.ufba.br/bitstream/ri/6699/1/Andrade%2c%20Luis%20Jesuino%20de%20Oliveira%20%282%29.pdf0f33616384771ef67c98e883631a590aMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6699/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTAndrade, Luis Jesuino de Oliveira (2).pdf.txtAndrade, Luis Jesuino de Oliveira (2).pdf.txtExtracted texttext/plain13215https://repositorio.ufba.br/bitstream/ri/6699/3/Andrade%2c%20Luis%20Jesuino%20de%20Oliveira%20%282%29.pdf.txt40fd98f5ca702d4cc99451c19b0b494eMD53ri/66992022-07-05 14:04:04.126oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:04Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers |
| dc.title.alternative.pt_BR.fl_str_mv |
Brazilian Journal of Infectious Diseases |
| title |
Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers |
| spellingShingle |
Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers Andrade, Luis Jesuino de Oliveira Hepatitis C Muscle Smooth Antibody specificity Cryoglobulins Liver diseases |
| title_short |
Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers |
| title_full |
Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers |
| title_fullStr |
Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers |
| title_full_unstemmed |
Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers |
| title_sort |
Smooth muscle antibodies and cryoglobulinemia are associated with advanced liver fibrosis in Brazilian hepatitis C virus carriers |
| author |
Andrade, Luis Jesuino de Oliveira |
| author_facet |
Andrade, Luis Jesuino de Oliveira Melo, Paulo Roberto Santana de Atta, Ajax Mercês Atta, Maria Luiza Brito de Sousa Jesus, Larissa Santana de Sousa, Gabriel Menezes de Silva, Carolina Alves Costa Paraná, Raymundo |
| author_role |
author |
| author2 |
Melo, Paulo Roberto Santana de Atta, Ajax Mercês Atta, Maria Luiza Brito de Sousa Jesus, Larissa Santana de Sousa, Gabriel Menezes de Silva, Carolina Alves Costa Paraná, Raymundo |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Andrade, Luis Jesuino de Oliveira Melo, Paulo Roberto Santana de Atta, Ajax Mercês Atta, Maria Luiza Brito de Sousa Jesus, Larissa Santana de Sousa, Gabriel Menezes de Silva, Carolina Alves Costa Paraná, Raymundo Andrade, Luis Jesuino de Oliveira Melo, Paulo Roberto Santana de Atta, Ajax Mercês Atta, Maria Luiza Brito de Sousa Jesus, Larissa Santana de Sousa, Gabriel Menezes de Silva, Carolina Alves Costa Paraná, Raymundo |
| dc.subject.por.fl_str_mv |
Hepatitis C Muscle Smooth Antibody specificity Cryoglobulins Liver diseases |
| topic |
Hepatitis C Muscle Smooth Antibody specificity Cryoglobulins Liver diseases |
| description |
p.66-68 |
| publishDate |
2011 |
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2011-01 |
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2012-09-06T11:47:05Z |
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2012-09-06T11:47:05Z |
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info:eu-repo/semantics/publishedVersion |
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http://www.repositorio.ufba.br/ri/handle/ri/6699 |
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1413-8670 |
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v. 15, n. 1 |
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1413-8670 v. 15, n. 1 |
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The Brazilian Journal of Infectious Diseases and Contexto Publishing |
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The Brazilian Journal of Infectious Diseases and Contexto Publishing |
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http://dx.doi.org/10.1590/S1413-86702011000100012 |
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