Effect of central acute administration of cadmium on drinking behavior

Detalhes bibliográficos
Autor(a) principal: Silva, E. de Castro E
Data de Publicação: 1996
Outros Autores: Ferreira, H., Cunha, M., Bulcão, C., Sarmento, Clarissa, Oliveira, I. de, Fregoneze, J. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8450
Resumo: Texto completo: acesso restrito. p.687–693
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spelling Silva, E. de Castro EFerreira, H.Cunha, M.Bulcão, C.Sarmento, ClarissaOliveira, I. deFregoneze, J. B.Silva, E. de Castro EFerreira, H.Cunha, M.Bulcão, C.Sarmento, ClarissaOliveira, I. deFregoneze, J. B.2013-02-15T16:03:14Z19960091-3057http://www.repositorio.ufba.br/ri/handle/ri/8450v3 53, n. 3Texto completo: acesso restrito. p.687–693The effect of acute third ventricle cadmium administration on the drinking behavior of adult male rats under different situations was studied. Injections of cadmium chloride (0.07, 0.7, and 7.0 ng/rat) significantly attenuated water intake in dehydrated rats. Drinking behavior induced by acute intracerebroventricular injections of carbachol (2 μg/rat) or angiotensin II (5 ng/rat) was also inhibited by central cadmium injections. Cadmium-induced blockade in water intake in dehydrated animals was reverted by the previous administration of a S-HT2 antagonist (RP62203) in different doses (5 and 10 μg/rat). The data clearly reveal that cadmium elicits very fast actions on the central nervous system. It is suggested that cadmium-induced attenuation of water intake may rely on at least three different mechanisms: impairment of cholinergic and angiotensinergic systems in the brain and stimulation of a central serotonergic drive acting on 5-HT2 receptors. The study of cadmium neurotoxicity by observation of drinking behavior, a behavioral parameter easy to be recorded and measured, is proposed.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-02-15T16:03:14Z No. of bitstreams: 1 castro.pdf: 873879 bytes, checksum: 5d3180e73e820b3ea1d7ccbbb68b1850 (MD5)Made available in DSpace on 2013-02-15T16:03:14Z (GMT). No. of bitstreams: 1 castro.pdf: 873879 bytes, checksum: 5d3180e73e820b3ea1d7ccbbb68b1850 (MD5) Previous issue date: 1996http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/0091-3057(95)02070-5reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACadmiumCadmium intoxicationCadmium neurotoxicityDrinking behaviorBrain angiotensinBrain cholinergic systemsBrain serotonergic systemsEffect of central acute administration of cadmium on drinking behaviorHealth Sciences Instituteinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALcastro.pdfcastro.pdfapplication/pdf873879https://repositorio.ufba.br/bitstream/ri/8450/1/castro.pdf5d3180e73e820b3ea1d7ccbbb68b1850MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8450/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTcastro.pdf.txtcastro.pdf.txtExtracted texttext/plain36881https://repositorio.ufba.br/bitstream/ri/8450/3/castro.pdf.txte95cb3c53d79313d6a04767cb409b70bMD53ri/84502022-07-05 14:03:01.804oai:repositorio.ufba.br:ri/8450VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIHJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBCgogICAgUGVsbyBwcm9jZXNzbyBkZSBzdWJtaXNz77+9byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldQpyZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBjb25jZWRlIGFvClJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSBvIGRpcmVpdG8KZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCAKZGUgcHJlc2VydmHvv73vv71vLiBFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIAphdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIGNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4gCgogICAgUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVp77+977+9bywgZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEgZW50ZW5kZSBxdWU6IAoKICAgIE1hbnRlbmRvIG9zICBkaXJlaXRvcyBhdXRvcmFpcywgcmVwYXNzYWRvcyBhIHRlcmNlaXJvcywgZW0gY2FzbyAKZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8gcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIAppbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1h77+977+9ZXMgc29icmUgbyBkb2N1bWVudG8gKE1ldGFkYWRvcyBkZXNjcml0aXZvcykuCgogRGVzdGEgZm9ybWEsIGF0ZW5kZW5kbyBhb3MgYW5zZWlvcyBkZXNzYSB1bml2ZXJzaWRhZGUgCmVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gYXMgcmVzdHJp77+977+9ZXMgaW1wb3N0YXMgcGVsb3MgCmVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4gCgogICAgUGFyYSBhcyBwdWJsaWNh77+977+9ZXMgZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgCkFjZXNzbyBBYmVydG8sIG9zIGRlcO+/vXNpdG9zIGNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gCm9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudO+/vW0gbyBhY2Vzc28gaXJyZXN0cml0byBhbyBtZXRhZGFkb3MgCmUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIApjb25zZW50aW1lbnRvIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgCmVzdGFyZW0gZW0gaW5pY2lhdGl2YXMgZGUgYWNlc3NvIGFiZXJ0by4KCiAgICBFbSBhbWJvcyBvIGNhc28sIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBwb2RlIHNlciBhY2VpdG8gcGVsbyAKYXV0b3IsIGRldGVudG9yZXMgZGUgZGlyZWl0b3MgZS9vdSB0ZXJjZWlyb3MgYW1wYXJhZG9zIHBlbGEgCnVuaXZlcnNpZGFkZS4gRGV2aWRvIGFvcyBkaWZlcmVudGVzIHByb2Nlc3NvcyBwZWxvIHF1YWwgYSBzdWJtaXNz77+9byAKcG9kZSBvY29ycmVyLCBvIHJlcG9zaXTvv71yaW8gcGVybWl0ZSBhIGFjZWl0Ye+/ve+/vW8gZGEgbGljZW7vv71hIHBvciAKdGVyY2Vpcm9zLCBzb21lbnRlIG5vcyBjYXNvcyBkZSBkb2N1bWVudG9zIHByb2R1emlkb3MgcG9yIGludGVncmFudGVzIApkYSBVRkJBIGUgc3VibWV0aWRvcyBwb3IgcGVzc29hcyBhbXBhcmFkYXMgcG9yIGVzdGEgaW5zdGl0dWnvv73vv71vLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:01Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Effect of central acute administration of cadmium on drinking behavior
dc.title.alternative.pt_BR.fl_str_mv Health Sciences Institute
title Effect of central acute administration of cadmium on drinking behavior
spellingShingle Effect of central acute administration of cadmium on drinking behavior
Silva, E. de Castro E
Cadmium
Cadmium intoxication
Cadmium neurotoxicity
Drinking behavior
Brain angiotensin
Brain cholinergic systems
Brain serotonergic systems
title_short Effect of central acute administration of cadmium on drinking behavior
title_full Effect of central acute administration of cadmium on drinking behavior
title_fullStr Effect of central acute administration of cadmium on drinking behavior
title_full_unstemmed Effect of central acute administration of cadmium on drinking behavior
title_sort Effect of central acute administration of cadmium on drinking behavior
author Silva, E. de Castro E
author_facet Silva, E. de Castro E
Ferreira, H.
Cunha, M.
Bulcão, C.
Sarmento, Clarissa
Oliveira, I. de
Fregoneze, J. B.
author_role author
author2 Ferreira, H.
Cunha, M.
Bulcão, C.
Sarmento, Clarissa
Oliveira, I. de
Fregoneze, J. B.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, E. de Castro E
Ferreira, H.
Cunha, M.
Bulcão, C.
Sarmento, Clarissa
Oliveira, I. de
Fregoneze, J. B.
Silva, E. de Castro E
Ferreira, H.
Cunha, M.
Bulcão, C.
Sarmento, Clarissa
Oliveira, I. de
Fregoneze, J. B.
dc.subject.por.fl_str_mv Cadmium
Cadmium intoxication
Cadmium neurotoxicity
Drinking behavior
Brain angiotensin
Brain cholinergic systems
Brain serotonergic systems
topic Cadmium
Cadmium intoxication
Cadmium neurotoxicity
Drinking behavior
Brain angiotensin
Brain cholinergic systems
Brain serotonergic systems
description Texto completo: acesso restrito. p.687–693
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2013-02-15T16:03:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8450
dc.identifier.issn.none.fl_str_mv 0091-3057
dc.identifier.number.pt_BR.fl_str_mv v3 53, n. 3
identifier_str_mv 0091-3057
v3 53, n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/8450
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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collection Repositório Institucional da UFBA
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