Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition

Detalhes bibliográficos
Autor(a) principal: Lima, Flávia Oliveira de
Data de Publicação: 2013
Outros Autores: Alves, Vivian, Barbosa Filho, José Maria, Almeida, Jackson Roberto Guedes da Silva, Rodrigues, Luis Cezar, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15820
Resumo: Texto completo: acesso restrito. p. 1557–1563
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spelling Lima, Flávia Oliveira deAlves, VivianBarbosa Filho, José MariaAlmeida, Jackson Roberto Guedes da SilvaRodrigues, Luis CezarSoares, Milena Botelho PereiraVillarreal, Cristiane FloraLima, Flávia Oliveira deAlves, VivianBarbosa Filho, José MariaAlmeida, Jackson Roberto Guedes da SilvaRodrigues, Luis CezarSoares, Milena Botelho PereiraVillarreal, Cristiane Flora2014-09-08T20:27:16Z20131742-5468http://repositorio.ufba.br/ri/handle/ri/15820v. 27, n. 10Texto completo: acesso restrito. p. 1557–1563The present study investigates the antinociceptive properties of lupeol in models of inflammatory and post-operative pain, as well as its mechanisms of action. The effects of lupeol were tested against acetic acid-induced writhing, formalin test, carrageenan-induced hyperalgesia, and post-operative pain model. Cytokine levels were determined by ELISA. Mice motor performance was evaluated in the rota rod and open-field tests. Pre-treatment of mice with lupeol (5–100 mg/kg IP) produced a dose-related inhibition of writhing in mice. The maximal antinociception produced by lupeol (60 mg/kg) was unaffected in mice pre-treated with yohimbine (α2 adrenoceptor antagonist; 2 mg/kg IP), L-arginine (substrate for nitric oxide synthase; 600 mg/kg IP), glibenclamide (the KATP-channel blocker; 2 mg/kg IP), and methysergide maleate (serotoninergic receptors antagonist; 5 mg/kg IP). Furthermore, lupeol (25–100 mg/kg) inhibited the late phase of formalin test. Pre-treatment with lupeol (50 and 100 mg/kg) inhibited the hyperalgesia and the local increase in tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels induced by carrageenan. In contrast, lupeol did not inhibit the post-operative pain. Lupeol-treated mice did not show any motor performance alterations or apparent systemic toxicity. Our results demonstrate that lupeol has consistent antinociceptive properties during inflammatory pain, but not post-operative pain, acting through the inhibition of IL-1β and TNF-α production.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-24T13:35:27Z No. of bitstreams: 1 10.1002ptr.4902.pdf: 237804 bytes, checksum: 8fb1facba729d829d7e76b35d51b82f5 (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-09-08T20:27:16Z (GMT) No. of bitstreams: 1 10.1002ptr.4902.pdf: 237804 bytes, checksum: 8fb1facba729d829d7e76b35d51b82f5 (MD5)Made available in DSpace on 2014-09-08T20:27:16Z (GMT). No. of bitstreams: 1 10.1002ptr.4902.pdf: 237804 bytes, checksum: 8fb1facba729d829d7e76b35d51b82f5 (MD5) Previous issue date: 2013http://dx.doi.org/10.1002/ptr.4902reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALonchocarpus araripensisLupeolAntinociceptionInflammatory painPost-operative painCytokinesAntinociceptive effect of lupeol: evidence for a role of cytokines inhibitionJournal of Statistical Mechanics: Theory and Experimentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL10.1002ptr.4902.pdf10.1002ptr.4902.pdfapplication/pdf237804https://repositorio.ufba.br/bitstream/ri/15820/1/10.1002ptr.4902.pdf8fb1facba729d829d7e76b35d51b82f5MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15820/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT10.1002ptr.4902.pdf.txt10.1002ptr.4902.pdf.txtExtracted texttext/plain36856https://repositorio.ufba.br/bitstream/ri/15820/3/10.1002ptr.4902.pdf.txtf6bdbdde355fe2c56ba4d0a6c78921d7MD53ri/158202022-07-05 14:03:32.97oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:32Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition
dc.title.alternative.pt_BR.fl_str_mv Journal of Statistical Mechanics: Theory and Experiment
title Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition
spellingShingle Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition
Lima, Flávia Oliveira de
Lonchocarpus araripensis
Lupeol
Antinociception
Inflammatory pain
Post-operative pain
Cytokines
title_short Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition
title_full Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition
title_fullStr Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition
title_full_unstemmed Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition
title_sort Antinociceptive effect of lupeol: evidence for a role of cytokines inhibition
author Lima, Flávia Oliveira de
author_facet Lima, Flávia Oliveira de
Alves, Vivian
Barbosa Filho, José Maria
Almeida, Jackson Roberto Guedes da Silva
Rodrigues, Luis Cezar
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author_role author
author2 Alves, Vivian
Barbosa Filho, José Maria
Almeida, Jackson Roberto Guedes da Silva
Rodrigues, Luis Cezar
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Flávia Oliveira de
Alves, Vivian
Barbosa Filho, José Maria
Almeida, Jackson Roberto Guedes da Silva
Rodrigues, Luis Cezar
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Lima, Flávia Oliveira de
Alves, Vivian
Barbosa Filho, José Maria
Almeida, Jackson Roberto Guedes da Silva
Rodrigues, Luis Cezar
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
dc.subject.por.fl_str_mv Lonchocarpus araripensis
Lupeol
Antinociception
Inflammatory pain
Post-operative pain
Cytokines
topic Lonchocarpus araripensis
Lupeol
Antinociception
Inflammatory pain
Post-operative pain
Cytokines
description Texto completo: acesso restrito. p. 1557–1563
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-09-08T20:27:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15820
dc.identifier.issn.none.fl_str_mv 1742-5468
dc.identifier.number.pt_BR.fl_str_mv v. 27, n. 10
identifier_str_mv 1742-5468
v. 27, n. 10
url http://repositorio.ufba.br/ri/handle/ri/15820
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1002/ptr.4902
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reponame_str Repositório Institucional da UFBA
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