Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy

Detalhes bibliográficos
Autor(a) principal: Lobo, Iza M. F.
Data de Publicação: 2006
Outros Autores: Soares, Milena Botelho Pereira, Correia, Tania M., Freitas, Luiz A. R. de, Oliveira, Maria Ines, Nakatani, Maria, Martins Netto, Eduardo, Badaró, Roberto José da Silva, David, John R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6496
Resumo: RESTRITO
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spelling Lobo, Iza M. F.Soares, Milena Botelho PereiraCorreia, Tania M.Freitas, Luiz A. R. deOliveira, Maria InesNakatani, MariaMartins Netto, EduardoBadaró, Roberto José da SilvaDavid, John R.Lobo, Iza M. F.Soares, Milena Botelho PereiraCorreia, Tania M.Freitas, Luiz A. R. deOliveira, Maria InesNakatani, MariaMartins Netto, EduardoBadaró, Roberto José da SilvaDavid, John R.2012-07-26T18:51:57Z2012-07-26T18:51:57Z20060035-9203http://www.repositorio.ufba.br/ri/handle/ri/6496v.100, n.7RESTRITOControlled heat delivered as radio waves has been used successfully in the treatment of cutaneous leishmaniasis (CL). Here we investigated whether local heat therapy has systemic effects, as measured by the modulation of cytokine production following heat therapy of CL lesions compared with antimonial (Glucantime) treatment. Patients with CL were randomly assigned into this study. Heat (50 °C for 30 s) was applied once. The control group received Glucantime therapy for 20 d. Cytokine production by peripheral blood mononuclear cells was assayed on days 0, 14 and 28 after onset of treatment. At the end of 28 d, 75% of lesions were healing or healed in the heat therapy group and 90% in the control group (P = 0.1261). There was a decrease in IFN-γ, IL-5 and TNF-α levels comparing day 0 with day 28 in both groups, but no difference between the two therapy groups. In patients with only one of several lesions treated with heat therapy, the untreated lesions also healed. Local heat therapy in CL lesions leads to systemic cytokine responses similar to that induced by systemic Glucantime therapy.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-07-26T18:51:57Z No. of bitstreams: 1 DD.pdf: 398422 bytes, checksum: ae297b66e3933ae1e6b007fde1cb0e59 (MD5)Made available in DSpace on 2012-07-26T18:51:57Z (GMT). No. of bitstreams: 1 DD.pdf: 398422 bytes, checksum: ae297b66e3933ae1e6b007fde1cb0e59 (MD5) Previous issue date: 2006SalvadorTransactions of the Royal Society of Tropical Medicine and Hygienehttp://dx.doi.org/10.1016/j.trstmh.2005.08.011reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniasisCutaneous leishmaniasisHeat therapyCytokineBrazilHeat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapyTransactions of the Royal Society of Tropical Medicine and Hygieneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALDD.pdfDD.pdfapplication/pdf398422https://repositorio.ufba.br/bitstream/ri/6496/1/DD.pdfae297b66e3933ae1e6b007fde1cb0e59MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6496/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTDD.pdf.txtDD.pdf.txtExtracted texttext/plain31976https://repositorio.ufba.br/bitstream/ri/6496/3/DD.pdf.txt701194522f0a65f17521eae731148d83MD53ri/64962022-07-05 14:03:13.436oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy
dc.title.alternative.pt_BR.fl_str_mv Transactions of the Royal Society of Tropical Medicine and Hygiene
title Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy
spellingShingle Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy
Lobo, Iza M. F.
Leishmaniasis
Cutaneous leishmaniasis
Heat therapy
Cytokine
Brazil
title_short Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy
title_full Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy
title_fullStr Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy
title_full_unstemmed Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy
title_sort Heat therapy for cutaneous leishmaniasis elicits a systemic cytokine response similar to that of antimonial (Glucantime) therapy
author Lobo, Iza M. F.
author_facet Lobo, Iza M. F.
Soares, Milena Botelho Pereira
Correia, Tania M.
Freitas, Luiz A. R. de
Oliveira, Maria Ines
Nakatani, Maria
Martins Netto, Eduardo
Badaró, Roberto José da Silva
David, John R.
author_role author
author2 Soares, Milena Botelho Pereira
Correia, Tania M.
Freitas, Luiz A. R. de
Oliveira, Maria Ines
Nakatani, Maria
Martins Netto, Eduardo
Badaró, Roberto José da Silva
David, John R.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lobo, Iza M. F.
Soares, Milena Botelho Pereira
Correia, Tania M.
Freitas, Luiz A. R. de
Oliveira, Maria Ines
Nakatani, Maria
Martins Netto, Eduardo
Badaró, Roberto José da Silva
David, John R.
Lobo, Iza M. F.
Soares, Milena Botelho Pereira
Correia, Tania M.
Freitas, Luiz A. R. de
Oliveira, Maria Ines
Nakatani, Maria
Martins Netto, Eduardo
Badaró, Roberto José da Silva
David, John R.
dc.subject.por.fl_str_mv Leishmaniasis
Cutaneous leishmaniasis
Heat therapy
Cytokine
Brazil
topic Leishmaniasis
Cutaneous leishmaniasis
Heat therapy
Cytokine
Brazil
description RESTRITO
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2012-07-26T18:51:57Z
dc.date.available.fl_str_mv 2012-07-26T18:51:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6496
dc.identifier.issn.none.fl_str_mv 0035-9203
dc.identifier.number.pt_BR.fl_str_mv v.100, n.7
identifier_str_mv 0035-9203
v.100, n.7
url http://www.repositorio.ufba.br/ri/handle/ri/6496
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Transactions of the Royal Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv Transactions of the Royal Society of Tropical Medicine and Hygiene
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.trstmh.2005.08.011
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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