Comparative Study of Hepatitis C Virus Genotypes 1 and 3 in Salvador, Bahia

Detalhes bibliográficos
Autor(a) principal: Codes, L.
Data de Publicação: 2003
Outros Autores: Freitas, L. A. R. de, Jesus, Rogério Santos, Vitvitski, Ludmila, Silva, L. K., Trepo, Christian, Reis, M. G., Paraná, Raymundo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/2937
Resumo: p.409-417
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spelling Codes, L.Freitas, L. A. R. deJesus, Rogério SantosVitvitski, LudmilaSilva, L. K.Trepo, ChristianReis, M. G.Paraná, RaymundoCodes, L.Freitas, L. A. R. deJesus, Rogério SantosVitvitski, LudmilaSilva, L. K.Trepo, ChristianReis, M. G.Paraná, Raymundo2011-09-28T14:31:04Z2011-09-28T14:31:04Z20031678-4391http://www.repositorio.ufba.br/ri/handle/ri/29377(6)p.409-417Hepatitis C virus displays a high degree of genetic mutation, with considerable heterogeneity, motivating clinical and biomolecular investigations. It is necessary to understand the effects of genotypes on the course of the disease, as well as their peculiarities at the regional level. Objective: The study objective was to compare epidemiological, biochemical and histological aspects of hepatitis C virus genotypes 1 and 3 in Salvador, Bahia. Study Design: Data were collected retrospectively from outpatient medical records. Materials and Methods: 127 patients with positive anti-HCV results were selected, based on detectable RNA-HCV (RT-PCR) of genotypes 1a, 1b and 3a. Results: Thirty-nine (30.7%) individuals were infected by subtype 1a, 45 (35.4%) by subtype 1b and 43 (33.9%) by subtype 3a. Most (73.2%) patients were male, with an average age of 47.8 years. The subtype 1b-infected patients had the highest average age (512 ±11.17; P=0.09). The use of illicit injected drugs was more frequent among subtype 3a infected individuals when compared with genotype 1 (6/43; 14% and 3/84; 3.6%, respectively; P=0,06). No significant differences were found for other epidemiological characteristics. Average values for GT, AST, ALT and ferritin did not differ between the groups (64, 78, 109, 276, respectively). Thyroid dysfunction occurred in 7/30 (23.3%) of those infected by genotype 3 (P=0.05). Cryoglobulinemia was also more frequent in this group (5/13, 38%, P=0.02). Most patients presented limited necro-inflammatory activity, stages 2 and 3 by the METAVIR Classification. In some cases, dissociation was noticed between inflammatory activity and fibrosis. No significant differences were found in the histopathological findings of the various genotypes. Younger patients had a significantly smaller degree of necrosis in stomatocytosis (P=0.032) and fibrosis (P=0.012). Intense parenchymatous activity and lymphoid follicles were more frequent among alcohol consumers (P=0.06 and P=0.04, respectively). Conclusions: In Bahia, genotype 3 dissemination seems to be associated with illicit drug use. The disease evolution depends on a function of complex interactions between virus and host. Age and alcohol consumption stand out as important variables in the development of cirrhosis.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2011-09-28T14:31:04Z No. of bitstreams: 1 18608.pdf: 51766 bytes, checksum: f40158fc353f9d150213a6cd057d9f75 (MD5)Made available in DSpace on 2011-09-28T14:31:04Z (GMT). No. of bitstreams: 1 18608.pdf: 51766 bytes, checksum: f40158fc353f9d150213a6cd057d9f75 (MD5) Previous issue date: 2003Hepatitis CGenotypeComparative Study of Hepatitis C Virus Genotypes 1 and 3 in Salvador, BahiaBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINAL18608.pdf18608.pdfapplication/pdf51766https://repositorio.ufba.br/bitstream/ri/2937/1/18608.pdff40158fc353f9d150213a6cd057d9f75MD51LICENSElicense.txtlicense.txttext/plain1918https://repositorio.ufba.br/bitstream/ri/2937/2/license.txt5d63c573c273d1bf0df9ad536a46d3c3MD52TEXT18608.pdf.txt18608.pdf.txtExtracted texttext/plain30594https://repositorio.ufba.br/bitstream/ri/2937/3/18608.pdf.txtf67b6abb3f7de3968883b2bf50582307MD53ri/29372022-07-05 14:03:31.436oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:31Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Comparative Study of Hepatitis C Virus Genotypes 1 and 3 in Salvador, Bahia
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Infectious Diseases
title Comparative Study of Hepatitis C Virus Genotypes 1 and 3 in Salvador, Bahia
spellingShingle Comparative Study of Hepatitis C Virus Genotypes 1 and 3 in Salvador, Bahia
Codes, L.
Hepatitis C
Genotype
title_short Comparative Study of Hepatitis C Virus Genotypes 1 and 3 in Salvador, Bahia
title_full Comparative Study of Hepatitis C Virus Genotypes 1 and 3 in Salvador, Bahia
title_fullStr Comparative Study of Hepatitis C Virus Genotypes 1 and 3 in Salvador, Bahia
title_full_unstemmed Comparative Study of Hepatitis C Virus Genotypes 1 and 3 in Salvador, Bahia
title_sort Comparative Study of Hepatitis C Virus Genotypes 1 and 3 in Salvador, Bahia
author Codes, L.
author_facet Codes, L.
Freitas, L. A. R. de
Jesus, Rogério Santos
Vitvitski, Ludmila
Silva, L. K.
Trepo, Christian
Reis, M. G.
Paraná, Raymundo
author_role author
author2 Freitas, L. A. R. de
Jesus, Rogério Santos
Vitvitski, Ludmila
Silva, L. K.
Trepo, Christian
Reis, M. G.
Paraná, Raymundo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Codes, L.
Freitas, L. A. R. de
Jesus, Rogério Santos
Vitvitski, Ludmila
Silva, L. K.
Trepo, Christian
Reis, M. G.
Paraná, Raymundo
Codes, L.
Freitas, L. A. R. de
Jesus, Rogério Santos
Vitvitski, Ludmila
Silva, L. K.
Trepo, Christian
Reis, M. G.
Paraná, Raymundo
dc.subject.por.fl_str_mv Hepatitis C
Genotype
topic Hepatitis C
Genotype
description p.409-417
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2011-09-28T14:31:04Z
dc.date.available.fl_str_mv 2011-09-28T14:31:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/2937
dc.identifier.issn.none.fl_str_mv 1678-4391
dc.identifier.number.pt_BR.fl_str_mv 7(6)
identifier_str_mv 1678-4391
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dc.language.iso.fl_str_mv eng
language eng
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