Human bocavirus infection diagnosed serologically among children admitted to hospital with community-acquired pneumonia in a tropical region

Detalhes bibliográficos
Autor(a) principal: Carvalho, Cristiana Maria Costa Nascimento de
Data de Publicação: 2012
Outros Autores: Cardoso, Maria Regina Alves, Meriluoto, Mira, Kemppainen, Kaisa, Kantola, Kalle, Ruuskanen, Olli, Hedman, Klaus, Venermo, Maria Söderlund
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16191
Resumo: Texto completo: acesso restrito. p. 253–258
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spelling Carvalho, Cristiana Maria Costa Nascimento deCardoso, Maria Regina AlvesMeriluoto, MiraKemppainen, KaisaKantola, KalleRuuskanen, OlliHedman, KlausVenermo, Maria SöderlundCarvalho, Cristiana Maria Costa Nascimento deCardoso, Maria Regina AlvesMeriluoto, MiraKemppainen, KaisaKantola, KalleRuuskanen, OlliHedman, KlausVenermo, Maria Söderlund2014-09-29T15:29:32Z20120146-6615http://repositorio.ufba.br/ri/handle/ri/16191v. 84, n. 2Texto completo: acesso restrito. p. 253–258Human bocavirus (HBoV) is a human virus associated with respiratory disease in children. Limited information is available on acute infection with HBoV among children admitted to hospital with community-acquired pneumonia in tropical regions and the current diagnosis is inadequate. The aims were to diagnose and describe acute HBoV infections among children hospitalized for community-acquired pneumonia. In Salvador, Brazil, 277 children with community-acquired pneumonia were prospectively enrolled. Paired serum samples were tested by IgG, IgM, and IgG-avidity enzyme immunoassays (EIAs) using recombinant HBoV VP2. HBoV DNA was detected in nasopharyngeal aspirates and serum by a quantitative polymerase-chain reaction (PCR). HBoV DNA was detected in nasopharyngeal aspirates of 62/268 (23%) children and 156/273 (57%) were seropositive. Acute primary HBoV infection was reliably diagnosed (bearing at least two acute markers: Positive IgM, a fourfold increase/conversion of IgG, low IgG avidity or viremia) in 21 (8%) of 273 patients, 90% of 20 had HBoV DNA in nasopharyngeal aspirates, 83% with a high DNA load. The median age of infection with HBoV was 16 months, range 5–36. Community-acquired pneumonia was confirmed radiographically in 85% of 20 patients with acute HBoV infection diagnosed serologically. HBoV DNA was found in nasopharyngeal aspirates of 42/246(17%) children without an acute primary HBoV infection and available nasopharyngeal aspirate. Four children with HBoV secondary immune responses were detected, lacking both IgM and viremia. HBoV infection was diagnosed accurately in children aged 5–36 months with community-acquired pneumonia confirmed radiographically. PCR of nasopharyngeal aspirates is not a reliable marker of acute HBoV infection.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-25T15:34:25Z No. of bitstreams: 1 Cristiana M. Nascimento Carvalho.pdf: 98916 bytes, checksum: bcf34646df407f6aa24b4de405ba28ca (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-09-29T15:29:32Z (GMT) No. of bitstreams: 1 Cristiana M. Nascimento Carvalho.pdf: 98916 bytes, checksum: bcf34646df407f6aa24b4de405ba28ca (MD5)Made available in DSpace on 2014-09-29T15:29:32Z (GMT). No. of bitstreams: 1 Cristiana M. Nascimento Carvalho.pdf: 98916 bytes, checksum: bcf34646df407f6aa24b4de405ba28ca (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1002/jmv.22268reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAcute respiratory infectionLower respiratory tract infectionRespiratory virusRespiratory tract infectionHuman bocavirus infection diagnosed serologically among children admitted to hospital with community-acquired pneumonia in a tropical regionJournal of Medical Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALCristiana M. Nascimento Carvalho.pdfCristiana M. 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dc.title.pt_BR.fl_str_mv Human bocavirus infection diagnosed serologically among children admitted to hospital with community-acquired pneumonia in a tropical region
dc.title.alternative.pt_BR.fl_str_mv Journal of Medical Virology
title Human bocavirus infection diagnosed serologically among children admitted to hospital with community-acquired pneumonia in a tropical region
spellingShingle Human bocavirus infection diagnosed serologically among children admitted to hospital with community-acquired pneumonia in a tropical region
Carvalho, Cristiana Maria Costa Nascimento de
Acute respiratory infection
Lower respiratory tract infection
Respiratory virus
Respiratory tract infection
title_short Human bocavirus infection diagnosed serologically among children admitted to hospital with community-acquired pneumonia in a tropical region
title_full Human bocavirus infection diagnosed serologically among children admitted to hospital with community-acquired pneumonia in a tropical region
title_fullStr Human bocavirus infection diagnosed serologically among children admitted to hospital with community-acquired pneumonia in a tropical region
title_full_unstemmed Human bocavirus infection diagnosed serologically among children admitted to hospital with community-acquired pneumonia in a tropical region
title_sort Human bocavirus infection diagnosed serologically among children admitted to hospital with community-acquired pneumonia in a tropical region
author Carvalho, Cristiana Maria Costa Nascimento de
author_facet Carvalho, Cristiana Maria Costa Nascimento de
Cardoso, Maria Regina Alves
Meriluoto, Mira
Kemppainen, Kaisa
Kantola, Kalle
Ruuskanen, Olli
Hedman, Klaus
Venermo, Maria Söderlund
author_role author
author2 Cardoso, Maria Regina Alves
Meriluoto, Mira
Kemppainen, Kaisa
Kantola, Kalle
Ruuskanen, Olli
Hedman, Klaus
Venermo, Maria Söderlund
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Cristiana Maria Costa Nascimento de
Cardoso, Maria Regina Alves
Meriluoto, Mira
Kemppainen, Kaisa
Kantola, Kalle
Ruuskanen, Olli
Hedman, Klaus
Venermo, Maria Söderlund
Carvalho, Cristiana Maria Costa Nascimento de
Cardoso, Maria Regina Alves
Meriluoto, Mira
Kemppainen, Kaisa
Kantola, Kalle
Ruuskanen, Olli
Hedman, Klaus
Venermo, Maria Söderlund
dc.subject.por.fl_str_mv Acute respiratory infection
Lower respiratory tract infection
Respiratory virus
Respiratory tract infection
topic Acute respiratory infection
Lower respiratory tract infection
Respiratory virus
Respiratory tract infection
description Texto completo: acesso restrito. p. 253–258
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-09-29T15:29:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16191
dc.identifier.issn.none.fl_str_mv 0146-6615
dc.identifier.number.pt_BR.fl_str_mv v. 84, n. 2
identifier_str_mv 0146-6615
v. 84, n. 2
url http://repositorio.ufba.br/ri/handle/ri/16191
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1002/jmv.22268
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