Self-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice

Detalhes bibliográficos
Autor(a) principal: Oliveira, Irismar Reis de
Data de Publicação: 1990
Outros Autores: Diquet, Bertrand, Meersch, Véronique Van der, Dardennes, Roland, Gonidec, Jean, Lima, Pedro Antônio do Prado de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7868
Resumo: Texto completo. Acesso restrito. p. 1 - 4
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spelling Oliveira, Irismar Reis deDiquet, BertrandMeersch, Véronique Van derDardennes, RolandGonidec, JeanLima, Pedro Antônio do Prado deOliveira, Irismar Reis deDiquet, BertrandMeersch, Véronique Van derDardennes, RolandGonidec, JeanLima, Pedro Antônio do Prado de2013-01-15T17:43:54Z2013-01-15T17:43:54Z19900033-3158http://www.repositorio.ufba.br/ri/handle/ri/7868v. 102, n. 4Texto completo. Acesso restrito. p. 1 - 4Animals were treated acutely with 0, 2.5, 5, 10, 20 and 40 mg/kg nortriptyline (NT) 30 rain before the tail suspension test (TST). They were sacrificed after test for evaluation of plasma and brain levels of NT. The antiimmobility effect increased with increasing doses and concentrations of the drug, reaching statistical significance (P<0.01, Dunnett test) at a dose of 20 mg/kg, 865 ng/ml in plasma and I1 gg/g in brain tissue. The anti-immobility effect was, however, blocked with the highest, non-toxic, concentrations. Results seem to indicate a biphasic curvilinear relationship between plasma and brain levels of NT and behaviour in mice.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-01-15T17:43:54Z No. of bitstreams: 1 EEEEEEEE15125.pdf: 445985 bytes, checksum: 54bd0e0236b1330f0998798a95c23c17 (MD5)Made available in DSpace on 2013-01-15T17:43:54Z (GMT). No. of bitstreams: 1 EEEEEEEE15125.pdf: 445985 bytes, checksum: 54bd0e0236b1330f0998798a95c23c17 (MD5) Previous issue date: 1990SalvadorPsychopharmacologyhttp://link.springer.com/content/pdf/10.1007%2FBF02247141reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBANortriptylinePlasma levelsBrain levelsTail suspension testMiceSelf-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in micePsychopharmacologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALEEEEEEEE15125.pdfEEEEEEEE15125.pdfapplication/pdf445985https://repositorio.ufba.br/bitstream/ri/7868/1/EEEEEEEE15125.pdf54bd0e0236b1330f0998798a95c23c17MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7868/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTEEEEEEEE15125.pdf.txtEEEEEEEE15125.pdf.txtExtracted texttext/plain15632https://repositorio.ufba.br/bitstream/ri/7868/3/EEEEEEEE15125.pdf.txt3e9a8e91e374c6f2dc352b35977f9bc9MD53ri/78682022-07-05 14:03:03.918oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Self-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice
dc.title.alternative.pt_BR.fl_str_mv Psychopharmacology
title Self-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice
spellingShingle Self-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice
Oliveira, Irismar Reis de
Nortriptyline
Plasma levels
Brain levels
Tail suspension test
Mice
title_short Self-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice
title_full Self-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice
title_fullStr Self-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice
title_full_unstemmed Self-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice
title_sort Self-inhibiting action of nortriptyline's anti-immobility effect at high plasma and brain levels in mice
author Oliveira, Irismar Reis de
author_facet Oliveira, Irismar Reis de
Diquet, Bertrand
Meersch, Véronique Van der
Dardennes, Roland
Gonidec, Jean
Lima, Pedro Antônio do Prado de
author_role author
author2 Diquet, Bertrand
Meersch, Véronique Van der
Dardennes, Roland
Gonidec, Jean
Lima, Pedro Antônio do Prado de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Irismar Reis de
Diquet, Bertrand
Meersch, Véronique Van der
Dardennes, Roland
Gonidec, Jean
Lima, Pedro Antônio do Prado de
Oliveira, Irismar Reis de
Diquet, Bertrand
Meersch, Véronique Van der
Dardennes, Roland
Gonidec, Jean
Lima, Pedro Antônio do Prado de
dc.subject.por.fl_str_mv Nortriptyline
Plasma levels
Brain levels
Tail suspension test
Mice
topic Nortriptyline
Plasma levels
Brain levels
Tail suspension test
Mice
description Texto completo. Acesso restrito. p. 1 - 4
publishDate 1990
dc.date.issued.fl_str_mv 1990
dc.date.accessioned.fl_str_mv 2013-01-15T17:43:54Z
dc.date.available.fl_str_mv 2013-01-15T17:43:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7868
dc.identifier.issn.none.fl_str_mv 0033-3158
dc.identifier.number.pt_BR.fl_str_mv v. 102, n. 4
identifier_str_mv 0033-3158
v. 102, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/7868
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Psychopharmacology
publisher.none.fl_str_mv Psychopharmacology
dc.source.pt_BR.fl_str_mv http://link.springer.com/content/pdf/10.1007%2FBF02247141
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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