Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis

Detalhes bibliográficos
Autor(a) principal: Hernigou, Philippe
Data de Publicação: 2010
Outros Autores: Daltro, Gildásio de Cerqueira, Lachaniette, Charles Henri Flouzat, Roussignol, Xavier, Poignard, Alexandre
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12810
Resumo: Texto completo: acesso restrito. p.1676-1681
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spelling Hernigou, PhilippeDaltro, Gildásio de CerqueiraLachaniette, Charles Henri FlouzatRoussignol, XavierPoignard, AlexandreHernigou, PhilippeDaltro, Gildásio de CerqueiraLachaniette, Charles Henri FlouzatRoussignol, XavierPoignard, Alexandre2013-09-03T12:46:05Z20100009-921Xhttp://www.repositorio.ufba.br/ri/handle/ri/12810v. 468, n. 6Texto completo: acesso restrito. p.1676-1681Background: Septic arthritis is a known complication of sickle cell disease (SCD) in children, and the association with osteomyelitis and osteonecrosis has been described. However, it is unclear whether this association applies to adults. Questions/Purposes We therefore asked whether septic arthritis is a frequent complication in adults with SCD and whether it also is associated with osteomyelitis or osteonecrosis. Methods We retrospectively reviewed the charts of 2000 consecutive adult patients diagnosed with SCD and recorded symptoms, select findings during physical examination, laboratory data, and select radiographic CT, and MRI observations. Results Fifty-nine of the 2000 patients (3%) had septic arthritis, 56 of the 59 patients had hemoglobin SS. Thirty-six of the 59 infections (61%) were in the hip. The most frequent findings were pain, swelling, fever greater than 38.2°C (71% of cases), a leukocyte count exceeding 15,000/mm3 (range, 7900–32,300/mm3), a Westergren sedimentation rate greater than 24 mm/hour, and C-reactive protein exceeding 20 mg/L. Cultures were positive in 96% of the joint aspirates. Staphylococcus and Gram-negative infection predominated; no patients had Salmonella joint infections. Preexisting factors of bacterial arthritis included osteonecrosis (29 patients) and osteomyelitis (37 cases) in childhood. Diabetes, rheumatoid arthritis, glucocorticoids, and immunoparesis related to medical treatment by hydroxyurea were associated comorbidities. CT and MRI confirmed the diagnosis of associated osteonecrosis or osteomyelitis and allowed joint aspiration and detection of soft tissue abscess. Conclusions: The incidence of septic arthritis in adults with SCD is low, but often is associated with osteomyelitis or osteonecrosis.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-08-28T13:37:56Z No. of bitstreams: 1 10.1007_s11999-009-1149-3.pdf: 192758 bytes, checksum: 4625f67ba5c681e188566f41c2143f5e (MD5)Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-09-03T12:46:05Z (GMT) No. of bitstreams: 1 10.1007_s11999-009-1149-3.pdf: 192758 bytes, checksum: 4625f67ba5c681e188566f41c2143f5e (MD5)Made available in DSpace on 2013-09-03T12:46:05Z (GMT). No. of bitstreams: 1 10.1007_s11999-009-1149-3.pdf: 192758 bytes, checksum: 4625f67ba5c681e188566f41c2143f5e (MD5) Previous issue date: 2010http://dx.doi.org/10.1007/s11999-009-1149-3reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAOsteonecrosisOsteomyelitisHydroxyureaSeptic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosisClinical Orthopaedics and Related Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL10.1007_s11999-009-1149-3.pdf10.1007_s11999-009-1149-3.pdfapplication/pdf192758https://repositorio.ufba.br/bitstream/ri/12810/1/10.1007_s11999-009-1149-3.pdf4625f67ba5c681e188566f41c2143f5eMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12810/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT10.1007_s11999-009-1149-3.pdf.txt10.1007_s11999-009-1149-3.pdf.txtExtracted texttext/plain28098https://repositorio.ufba.br/bitstream/ri/12810/3/10.1007_s11999-009-1149-3.pdf.txt463b77f9a5beb8d1779c2e326cfe2774MD53ri/128102022-08-08 13:18:15.697oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:18:15Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis
dc.title.alternative.pt_BR.fl_str_mv Clinical Orthopaedics and Related Research
title Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis
spellingShingle Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis
Hernigou, Philippe
Osteonecrosis
Osteomyelitis
Hydroxyurea
title_short Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis
title_full Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis
title_fullStr Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis
title_full_unstemmed Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis
title_sort Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis
author Hernigou, Philippe
author_facet Hernigou, Philippe
Daltro, Gildásio de Cerqueira
Lachaniette, Charles Henri Flouzat
Roussignol, Xavier
Poignard, Alexandre
author_role author
author2 Daltro, Gildásio de Cerqueira
Lachaniette, Charles Henri Flouzat
Roussignol, Xavier
Poignard, Alexandre
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Hernigou, Philippe
Daltro, Gildásio de Cerqueira
Lachaniette, Charles Henri Flouzat
Roussignol, Xavier
Poignard, Alexandre
Hernigou, Philippe
Daltro, Gildásio de Cerqueira
Lachaniette, Charles Henri Flouzat
Roussignol, Xavier
Poignard, Alexandre
dc.subject.por.fl_str_mv Osteonecrosis
Osteomyelitis
Hydroxyurea
topic Osteonecrosis
Osteomyelitis
Hydroxyurea
description Texto completo: acesso restrito. p.1676-1681
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-09-03T12:46:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12810
dc.identifier.issn.none.fl_str_mv 0009-921X
dc.identifier.number.pt_BR.fl_str_mv v. 468, n. 6
identifier_str_mv 0009-921X
v. 468, n. 6
url http://www.repositorio.ufba.br/ri/handle/ri/12810
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1007/s11999-009-1149-3
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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