HTLV-1 modifies the clinical and immunological response to schistosomiasis

Detalhes bibliográficos
Autor(a) principal: Porto, Maria Aurélia da Fonseca
Data de Publicação: 2004
Outros Autores: Santos, S. B., Alcântara, Leda Maria, Guerreiro, J. B., Passos, J., Gonzalez, T., Neva, Franklin A., Gonzalez, D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7192
Resumo: p. 424-429
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spelling Porto, Maria Aurélia da FonsecaSantos, S. B.Alcântara, Leda MariaGuerreiro, J. B.Passos, J.Gonzalez, T.Neva, Franklin A.Gonzalez, D.Porto, Maria Aurélia da FonsecaSantos, S. B.Alcântara, Leda MariaGuerreiro, J. B.Passos, J.Gonzalez, T.Neva, Franklin A.Gonzalez, D.2012-11-13T13:29:28Z20040009-9104http://www.repositorio.ufba.br/ri/handle/ri/7192v. 137, n. 2p. 424-429The immunological response in HTLV-1 infected individuals is characterized by a prominent Type-1 cytokine response with high production of IFNg and TNFa. In contrast, helminthic infections and in particular chronic schistosomiasis are associated with a predominant production of IL-4, IL-5, IL-10 and IL-13. Liver fibrosis is the main pathological finding in schistosomiasis that occurs after many years of infection. This pathology is T cell dependent but the immune response mechanisms are not completely understood. The North-east region of Brazil is endemic for both HTLV-1 and schistosomiasis. In the present study the immune response, clinical severity, and therapeutic response to praziquantel of patients with schistosomiasis coinfected with HTLV-1 were compared with patients infected only with S. mansoni. Patients with HTLV-1 and S.mansoni had lower levels of IL-5 (P<0·05) and higher levelsof (P<0·05) in cultures stimulated with S. manson antigen and decreased S. mansoni antigen specific IgE levels when compared with patients with schistosomiasis without HTLV-1 coinfection. Liver fibrosis was mild in all HTLV-1 coinfected patients and efficacy of praziquantel was lower in patients dually infected than in patients infected only with S. mansoni.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-11-13T13:29:28Z No. of bitstreams: 1 CONFIG~1....1365-2249.2004.02508.x-1.pdf: 66846 bytes, checksum: 5cf8fbf30ecb0b9ad00d4867363bc580 (MD5)Made available in DSpace on 2012-11-13T13:29:28Z (GMT). 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dc.title.pt_BR.fl_str_mv HTLV-1 modifies the clinical and immunological response to schistosomiasis
dc.title.alternative.pt_BR.fl_str_mv Clinical and Experimental Immunology
title HTLV-1 modifies the clinical and immunological response to schistosomiasis
spellingShingle HTLV-1 modifies the clinical and immunological response to schistosomiasis
Porto, Maria Aurélia da Fonseca
HTLV-1
schistosomiasis
liver fibrosis
title_short HTLV-1 modifies the clinical and immunological response to schistosomiasis
title_full HTLV-1 modifies the clinical and immunological response to schistosomiasis
title_fullStr HTLV-1 modifies the clinical and immunological response to schistosomiasis
title_full_unstemmed HTLV-1 modifies the clinical and immunological response to schistosomiasis
title_sort HTLV-1 modifies the clinical and immunological response to schistosomiasis
author Porto, Maria Aurélia da Fonseca
author_facet Porto, Maria Aurélia da Fonseca
Santos, S. B.
Alcântara, Leda Maria
Guerreiro, J. B.
Passos, J.
Gonzalez, T.
Neva, Franklin A.
Gonzalez, D.
author_role author
author2 Santos, S. B.
Alcântara, Leda Maria
Guerreiro, J. B.
Passos, J.
Gonzalez, T.
Neva, Franklin A.
Gonzalez, D.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Porto, Maria Aurélia da Fonseca
Santos, S. B.
Alcântara, Leda Maria
Guerreiro, J. B.
Passos, J.
Gonzalez, T.
Neva, Franklin A.
Gonzalez, D.
Porto, Maria Aurélia da Fonseca
Santos, S. B.
Alcântara, Leda Maria
Guerreiro, J. B.
Passos, J.
Gonzalez, T.
Neva, Franklin A.
Gonzalez, D.
dc.subject.por.fl_str_mv HTLV-1
schistosomiasis
liver fibrosis
topic HTLV-1
schistosomiasis
liver fibrosis
description p. 424-429
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-11-13T13:29:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7192
dc.identifier.issn.none.fl_str_mv 0009-9104
dc.identifier.number.pt_BR.fl_str_mv v. 137, n. 2
identifier_str_mv 0009-9104
v. 137, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/7192
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.pt_BR.fl_str_mv http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2004.02508.x/pdf
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