CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Dantas, Marina Loyola
Data de Publicação: 2013
Outros Autores: Oliveira, Juliana Cabral de, Carvalho, Lucas Pedreira de, Passos, Sara Timóteo, Queiroz, Adriano, Machado, Paulo Roberto Lima, Carvalho Filho, Edgar Marcelino de, Arruda, Sérgio Marcos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15911
Resumo: p. 728-734
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spelling Dantas, Marina LoyolaOliveira, Juliana Cabral deCarvalho, Lucas Pedreira dePassos, Sara TimóteoQueiroz, AdrianoMachado, Paulo Roberto LimaCarvalho Filho, Edgar Marcelino deArruda, Sérgio MarcosDantas, Marina LoyolaOliveira, Juliana Cabral deCarvalho, Lucas Pedreira dePassos, Sara TimóteoQueiroz, AdrianoMachado, Paulo Roberto LimaCarvalho Filho, Edgar Marcelino deArruda, Sérgio Marcos2014-09-09T15:06:29Z2014-09-09T15:06:29Z20130037-8682http://repositorio.ufba.br/ri/handle/ri/15911v. 46, n. 6p. 728-734Introduction: Leishmania braziliensis infection induces a large spectrum of lesions that clinically manifest as nodules or papules that progress to ulcers. Although it is already known that T helper cells predominate in the lesions, cytotoxic T cells have also been reported to be present, and their role in leishmaniasis immunopathogenesis is not well known. This study investigated the amounts of CD8+ and granzyme B+ cells in different clinical forms of human cutaneous leishmaniasis (CL). Methods: Forty tissue fragments from early (E-CL) and late CL (L-CL) lesions and from disseminated leishmaniasis (DL) - papules and ulcers - were characterized. The inflamed area per fragment was calculated, and the CD8 and granzyme B expression levels in the infiltrates were quantified by counting positive cells in 15 fields. The localization of CD8 and granzyme B was graded subjectively. Results: Inflammation was higher in L-CL and DL ulcers. CD8 expression was increased in late ulcerated lesions compared to recent lesions. The increase in CD8+ cells also correlated with the duration of the lesion. Papules had a higher frequency of granzyme B+ cells than E-CL lesions, although the frequency was similar to those for late and DL ulcers. CD8+ cells were mostly found in the papillary dermis. Conclusions: CD8+ T and granzyme B+ cells are present in the inflammatory infiltrates of CL and DL and may participate in the immunopathogenesis of Leishmania infection.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-15T11:41:41Z No. of bitstreams: 1 0037-8682-rsbmt-46-06-728.pdf: 2478160 bytes, checksum: ff70ece107c21adcef550b94d28d6b52 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T15:06:29Z (GMT) No. of bitstreams: 1 0037-8682-rsbmt-46-06-728.pdf: 2478160 bytes, checksum: ff70ece107c21adcef550b94d28d6b52 (MD5)Made available in DSpace on 2014-09-09T15:06:29Z (GMT). No. of bitstreams: 1 0037-8682-rsbmt-46-06-728.pdf: 2478160 bytes, checksum: ff70ece107c21adcef550b94d28d6b52 (MD5) Previous issue date: 2013http://dx.doi.org/10.1590/0037-8682-0174-2013reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniasisCytotoxicityInflammationCutaneousCD8HumanCD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasisRevista da Sociedade Brasileira de Medicina Tropicalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINAL0037-8682-rsbmt-46-06-728.pdf0037-8682-rsbmt-46-06-728.pdfapplication/pdf2478160https://repositorio.ufba.br/bitstream/ri/15911/1/0037-8682-rsbmt-46-06-728.pdfff70ece107c21adcef550b94d28d6b52MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15911/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT0037-8682-rsbmt-46-06-728.pdf.txt0037-8682-rsbmt-46-06-728.pdf.txtExtracted texttext/plain27651https://repositorio.ufba.br/bitstream/ri/15911/3/0037-8682-rsbmt-46-06-728.pdf.txtd341474606cf5123353a72be1161f638MD53ri/159112022-07-05 14:05:18.298oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:05:18Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis
dc.title.alternative.pt_BR.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical
title CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis
spellingShingle CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis
Dantas, Marina Loyola
Leishmaniasis
Cytotoxicity
Inflammation
Cutaneous
CD8
Human
title_short CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis
title_full CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis
title_fullStr CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis
title_full_unstemmed CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis
title_sort CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis
author Dantas, Marina Loyola
author_facet Dantas, Marina Loyola
Oliveira, Juliana Cabral de
Carvalho, Lucas Pedreira de
Passos, Sara Timóteo
Queiroz, Adriano
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
Arruda, Sérgio Marcos
author_role author
author2 Oliveira, Juliana Cabral de
Carvalho, Lucas Pedreira de
Passos, Sara Timóteo
Queiroz, Adriano
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
Arruda, Sérgio Marcos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dantas, Marina Loyola
Oliveira, Juliana Cabral de
Carvalho, Lucas Pedreira de
Passos, Sara Timóteo
Queiroz, Adriano
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
Arruda, Sérgio Marcos
Dantas, Marina Loyola
Oliveira, Juliana Cabral de
Carvalho, Lucas Pedreira de
Passos, Sara Timóteo
Queiroz, Adriano
Machado, Paulo Roberto Lima
Carvalho Filho, Edgar Marcelino de
Arruda, Sérgio Marcos
dc.subject.por.fl_str_mv Leishmaniasis
Cytotoxicity
Inflammation
Cutaneous
CD8
Human
topic Leishmaniasis
Cytotoxicity
Inflammation
Cutaneous
CD8
Human
description p. 728-734
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-09-09T15:06:29Z
dc.date.available.fl_str_mv 2014-09-09T15:06:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15911
dc.identifier.issn.none.fl_str_mv 0037-8682
dc.identifier.number.pt_BR.fl_str_mv v. 46, n. 6
identifier_str_mv 0037-8682
v. 46, n. 6
url http://repositorio.ufba.br/ri/handle/ri/15911
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/0037-8682-0174-2013
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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