Human major histocompatibility complex and thyroid dysfunction in hepatitis C carries

Detalhes bibliográficos
Autor(a) principal: Andrade, Luis Jesuino de Oliveira
Data de Publicação: 2011
Outros Autores: Melo, Paulo Roberto Santana de, França, Larissa Santos, França, Luciana Santos, Malta, Ana Micheline Andrade, Paraná, Raymundo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/22806
Resumo: Key Words: Major histocompatibility complex. Hepatitis C. Interferon-alpha. Thyroid dysfunction. Autoimmunity.
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spelling Andrade, Luis Jesuino de OliveiraMelo, Paulo Roberto Santana deFrança, Larissa SantosFrança, Luciana SantosMalta, Ana Micheline AndradeParaná, RaymundoAndrade, Luis Jesuino de OliveiraMelo, Paulo Roberto Santana deFrança, Larissa SantosFrança, Luciana SantosMalta, Ana Micheline AndradeParaná, Raymundo2017-06-05T19:17:25Z2017-06-05T19:17:25Z2011-05R. Ci. med. biol., Salvador, v.10, n.2, p.179-186, mai./ago. 20112236-5222http://repositorio.ufba.br/ri/handle/ri/22806v.10, n. 2Key Words: Major histocompatibility complex. Hepatitis C. Interferon-alpha. Thyroid dysfunction. Autoimmunity.Abstract The major histocompatibility complex (MHC) is a multigenice family of receptors which are crucial in antigen presentation, mediation, and initiation of the cellular immune response. An association exists between certain MHC polymorphisms and autoimmune thyroid disease in animals and humans. Hepatitis C virus (HCV) infection the treatment of hepatitis C with interferon- (IFN- )have been shown to be associated with increased incidence of thyroid dysfunction. IFN- has been the basis for the treatment of HCV infection identified as an immunomodulatory cytokine that induces T-lymphocyte activation and expression of MHC molecules. It becomes evident therefore that the MHC- class I and MHC- class II antigens are central to the host immune response and thus are ideal candidate genes to investigate for associations with HCV infection. Autoimmune thyroid diseases are characterized by increased, rather than decreased expression, of MHC- class II antigen. Furthermore, work in animals suggests that the increased production of thyroid antibody and expression of MHC- class I and MHC- class II antigen are associated. This study will approach the relation between MHC and thyroid dysfunction in HCV infection carries.Submitted by ROBERTO PAULO CORREIA DE ARAÚJO (ppgorgsistem@ufba.br) on 2017-06-05T19:17:25Z No. of bitstreams: 1 13_v.10_2.pdf: 803788 bytes, checksum: 4e5430dce5e898c3dafe28a4782605bf (MD5)Made available in DSpace on 2017-06-05T19:17:25Z (GMT). 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dc.title.pt_BR.fl_str_mv Human major histocompatibility complex and thyroid dysfunction in hepatitis C carries
dc.title.alternative.pt_BR.fl_str_mv Revista de Ciências Médicas e Biológicas
title Human major histocompatibility complex and thyroid dysfunction in hepatitis C carries
spellingShingle Human major histocompatibility complex and thyroid dysfunction in hepatitis C carries
Andrade, Luis Jesuino de Oliveira
Complexo de histocompatibilidade maior
Hepatite C
Interferon-alfa
Disfunção da tireóide
Auto-imunidade.
title_short Human major histocompatibility complex and thyroid dysfunction in hepatitis C carries
title_full Human major histocompatibility complex and thyroid dysfunction in hepatitis C carries
title_fullStr Human major histocompatibility complex and thyroid dysfunction in hepatitis C carries
title_full_unstemmed Human major histocompatibility complex and thyroid dysfunction in hepatitis C carries
title_sort Human major histocompatibility complex and thyroid dysfunction in hepatitis C carries
author Andrade, Luis Jesuino de Oliveira
author_facet Andrade, Luis Jesuino de Oliveira
Melo, Paulo Roberto Santana de
França, Larissa Santos
França, Luciana Santos
Malta, Ana Micheline Andrade
Paraná, Raymundo
author_role author
author2 Melo, Paulo Roberto Santana de
França, Larissa Santos
França, Luciana Santos
Malta, Ana Micheline Andrade
Paraná, Raymundo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Luis Jesuino de Oliveira
Melo, Paulo Roberto Santana de
França, Larissa Santos
França, Luciana Santos
Malta, Ana Micheline Andrade
Paraná, Raymundo
Andrade, Luis Jesuino de Oliveira
Melo, Paulo Roberto Santana de
França, Larissa Santos
França, Luciana Santos
Malta, Ana Micheline Andrade
Paraná, Raymundo
dc.subject.por.fl_str_mv Complexo de histocompatibilidade maior
Hepatite C
Interferon-alfa
Disfunção da tireóide
Auto-imunidade.
topic Complexo de histocompatibilidade maior
Hepatite C
Interferon-alfa
Disfunção da tireóide
Auto-imunidade.
description Key Words: Major histocompatibility complex. Hepatitis C. Interferon-alpha. Thyroid dysfunction. Autoimmunity.
publishDate 2011
dc.date.issued.fl_str_mv 2011-05
dc.date.accessioned.fl_str_mv 2017-06-05T19:17:25Z
dc.date.available.fl_str_mv 2017-06-05T19:17:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv R. Ci. med. biol., Salvador, v.10, n.2, p.179-186, mai./ago. 2011
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/22806
dc.identifier.issn.none.fl_str_mv 2236-5222
dc.identifier.number.pt_BR.fl_str_mv v.10, n. 2
identifier_str_mv R. Ci. med. biol., Salvador, v.10, n.2, p.179-186, mai./ago. 2011
2236-5222
v.10, n. 2
url http://repositorio.ufba.br/ri/handle/ri/22806
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto de Ciências da Saúde/ Universidade Federal da Bahia
dc.publisher.country.fl_str_mv Brasil
publisher.none.fl_str_mv Instituto de Ciências da Saúde/ Universidade Federal da Bahia
dc.source.pt_BR.fl_str_mv http://www.portalseer.ufba.br/index.php/cmbio/article/view/4825/4173
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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