Association between haptoglobin and IgM levels and the clinical progression of caseous lymphadenitis in sheep
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14770 |
Resumo: | p. 2-7 |
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Bastos, Bruno LopesLoureiro, DanRaynal, José T.Guedes, Maria T.Vale, Vera Lúcia CostaCosta, Lilia F. MouraGuimarães, José E.Azevedo, Vasco Ariston de CarvalhoPortela, Ricardo Wagner DiasNascimento, Roberto José Meyer2014-03-21T20:44:30Z2014-03-21T20:44:30Z20131746-6148http://repositorio.ufba.br/ri/handle/ri/14770v. 9, n. 254p. 2-7Background: Sheep caseous lymphadenitis (CLA), caused by Corynebacterium pseudotuberculosis (Cp), is associated with direct economic losses and presents significant zoonotic potential. Despite the importance of the disease, a satisfactory vaccine model has not been developed. Thus, this study aimed to investigate the association between haptoglobin (Hp) and IgM levels and the clinical progression of CLA in primarily infected sheep and in sheep immunized with Cp- secreted antigens adjuvanted with Quillaja saponaria saponins. These animals were kept with CLA-positive sheep to simulate natural exposure that occurs in field conditions. During the experiment, the Hp and IgM levels were monitored for 21 days, and the development of internal CLA lesions was investigated through necropsies on day182 post-immunization. Results: Primarily infected sheep in Group 2 (inoculated with 2x105 Cp virulent strain) had higher Hp values between the first and ninth days post inoculation (PI) than sheep in Group 1 (control; P < 0.05). Immunized animals in Group 3 had significantly higher Hp values between the third and seventh days PI, compared with the control group (P < 0.01). Binary logistic regression (BLR) analysis of primarily infected sheep indicated an association between Hp concentration and CLA clinical progression: animals with high Hp values had 99.9% less risk of having CLA abscesses than animals with low Hp levels (Odds ratio = 0.001, P < 0.05). Both experimental groups had significantly higher IgM titers than the control group around the ninth and eleventh days PI (P < 0.05). The BLR analysis for immunized sheep indicated an association between IgM levels and clinical progression: sheep with high IgM titers had 100.0% less risk of having CLA abscesses than animals with low IgM levels (Odds ratio = 0.000, P < 0.05). Conclusions: Resistance to C. pseudotuberculosis infection is supported by the early acute phase response, in which up-regulation of Hp and IgM were predictive of a lower risk of CLA lesion development. Because the immunogen used in this study induced a high production of both Hp and IgM, Q. saponaria saponin should be considered a promising candidate in vaccine formulations against sheep CLA.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-03-20T13:12:27Z No. of bitstreams: 1 1746-6148-9-254.pdf: 694892 bytes, checksum: 2be9693d86424f2d32b669bf02848372 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-03-21T20:44:30Z (GMT) No. of bitstreams: 1 1746-6148-9-254.pdf: 694892 bytes, checksum: 2be9693d86424f2d32b669bf02848372 (MD5)Made available in DSpace on 2014-03-21T20:44:30Z (GMT). No. of bitstreams: 1 1746-6148-9-254.pdf: 694892 bytes, checksum: 2be9693d86424f2d32b669bf02848372 (MD5) Previous issue date: 2013http://dx.doi.org/10.1186/1746-6148-9-254reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACaseous lymphadenitisSmall ruminantsQuillaja saponariaAcute phase responseHaptoglobinImmunoglobulin MAssociation between haptoglobin and IgM levels and the clinical progression of caseous lymphadenitis in sheepBMC Veterinary Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINAL1746-6148-9-254.pdf1746-6148-9-254.pdfapplication/pdf694892https://repositorio.ufba.br/bitstream/ri/14770/1/1746-6148-9-254.pdf2be9693d86424f2d32b669bf02848372MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14770/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT1746-6148-9-254.pdf.txt1746-6148-9-254.pdf.txtExtracted texttext/plain33286https://repositorio.ufba.br/bitstream/ri/14770/3/1746-6148-9-254.pdf.txt67000f73b2a28a5286279eab96aabc92MD53ri/147702022-02-21 00:10:17.511oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-02-21T03:10:17Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Association between haptoglobin and IgM levels and the clinical progression of caseous lymphadenitis in sheep |
| dc.title.alternative.pt_BR.fl_str_mv |
BMC Veterinary Research |
| title |
Association between haptoglobin and IgM levels and the clinical progression of caseous lymphadenitis in sheep |
| spellingShingle |
Association between haptoglobin and IgM levels and the clinical progression of caseous lymphadenitis in sheep Bastos, Bruno Lopes Caseous lymphadenitis Small ruminants Quillaja saponaria Acute phase response Haptoglobin Immunoglobulin M |
| title_short |
Association between haptoglobin and IgM levels and the clinical progression of caseous lymphadenitis in sheep |
| title_full |
Association between haptoglobin and IgM levels and the clinical progression of caseous lymphadenitis in sheep |
| title_fullStr |
Association between haptoglobin and IgM levels and the clinical progression of caseous lymphadenitis in sheep |
| title_full_unstemmed |
Association between haptoglobin and IgM levels and the clinical progression of caseous lymphadenitis in sheep |
| title_sort |
Association between haptoglobin and IgM levels and the clinical progression of caseous lymphadenitis in sheep |
| author |
Bastos, Bruno Lopes |
| author_facet |
Bastos, Bruno Lopes Loureiro, Dan Raynal, José T. Guedes, Maria T. Vale, Vera Lúcia Costa Costa, Lilia F. Moura Guimarães, José E. Azevedo, Vasco Ariston de Carvalho Portela, Ricardo Wagner Dias Nascimento, Roberto José Meyer |
| author_role |
author |
| author2 |
Loureiro, Dan Raynal, José T. Guedes, Maria T. Vale, Vera Lúcia Costa Costa, Lilia F. Moura Guimarães, José E. Azevedo, Vasco Ariston de Carvalho Portela, Ricardo Wagner Dias Nascimento, Roberto José Meyer |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bastos, Bruno Lopes Loureiro, Dan Raynal, José T. Guedes, Maria T. Vale, Vera Lúcia Costa Costa, Lilia F. Moura Guimarães, José E. Azevedo, Vasco Ariston de Carvalho Portela, Ricardo Wagner Dias Nascimento, Roberto José Meyer |
| dc.subject.por.fl_str_mv |
Caseous lymphadenitis Small ruminants Quillaja saponaria Acute phase response Haptoglobin Immunoglobulin M |
| topic |
Caseous lymphadenitis Small ruminants Quillaja saponaria Acute phase response Haptoglobin Immunoglobulin M |
| description |
p. 2-7 |
| publishDate |
2013 |
| dc.date.issued.fl_str_mv |
2013 |
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2014-03-21T20:44:30Z |
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2014-03-21T20:44:30Z |
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http://repositorio.ufba.br/ri/handle/ri/14770 |
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1746-6148 |
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v. 9, n. 254 |
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1746-6148 v. 9, n. 254 |
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