Dietary antioxidant deficiency facilitates cortical spreading depression induced by photoactivated riboflavin

Detalhes bibliográficos
Autor(a) principal: El-Bachá, Ramon dos Santos
Data de Publicação: 1998
Outros Autores: Lima Filho, José L. de, Guedes, Rubem C. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7194
Resumo: Trabalho resultante do mestrado do primeiro autor.
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spelling El-Bachá, Ramon dos SantosLima Filho, José L. deGuedes, Rubem C. A.El-Bachá, Ramon dos SantosLima Filho, José L. deGuedes, Rubem C. A.2012-11-13T17:13:43Z19981028415Xhttp://www.repositorio.ufba.br/ri/handle/ri/7194v. 1 , n. 3Trabalho resultante do mestrado do primeiro autor.It is known that the photoactivation of riboflavin produces superoxide radicals. We investigated the ability of this process to elicit spreading depression (SD) in the cerebral cortex of adult rats receiving either a normal diet (control group; n = 9) or fed a diet free from vitamins C and E during 4-6 weeks prior to the experiment (deficient group; n = 15). SD was initially elicited, at 20 min intervals, by 2% KCl topically applied for 1 min to a point (2-3 mm in diameter) on the dura mater at the frontal cortex and SD propagation was monitored by both EEG and DC-recordings at two points of the parietal region. After a 1-2 h "baseline" recording of KCl-elicited SD, tests were performed with 1.0 mM riboflavin applied to the same frontal region and illuminated by a white light bulb (40 W, 10-15 cm from the cortical surface, for 1-3 min). In the control group, 37 applications of riboflavin + light were performed (average: 4.1 applications per rat; range: 3-7) and 11 of these applications (29.7%) elicited SD in 7 out of the 9 rats. In the deficient group, the effectiveness of photoactivated riboflavin to elicit SD increased significantly to 62.8% (44 out of 70 applications; 15 out of 15 rats; average: 4.7 applications per rat; range: 3-6; P < 0.05). Elicitation of SD was not obtained, either by illumination of an equivalent volume of Ringer solution applied to the same region, or by riboflavin applied without illumination. The results demonstrate that photoactivated riboflavin is capable of eliciting SD in the rat cerebral cortex, and that dietary deficiency of the antioxidant vitamins C and E can enhance brain susceptibility to this process.Submitted by Ramon El-Bachá (ramon@ufba.br) on 2012-11-13T17:13:43Z No. of bitstreams: 1 El-Bachá et al 1998.pdf: 3567509 bytes, checksum: 554368e64721a65388e0e9fe67a8ed9b (MD5)Made available in DSpace on 2012-11-13T17:13:43Z (GMT). No. of bitstreams: 1 El-Bachá et al 1998.pdf: 3567509 bytes, checksum: 554368e64721a65388e0e9fe67a8ed9b (MD5) Previous issue date: 1998CAPES, UFBA, LIKA, UFPE, CNPq.MalaysiaOverseas Publishers AssociationAscorbic acidVitamin EFree RadicalsRibloflavinSpreading dpressionSuperoxideDietary antioxidant deficiency facilitates cortical spreading depression induced by photoactivated riboflavininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01engreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1809https://repositorio.ufba.br/bitstream/ri/7194/2/license.txt8bb3e3eb871f5854a9ec419f68651b60MD52ORIGINALEl-Bachá et al 1998.pdfEl-Bachá et al 1998.pdfapplication/pdf3567509https://repositorio.ufba.br/bitstream/ri/7194/1/El-Bach%c3%a1%20et%20al%201998.pdf554368e64721a65388e0e9fe67a8ed9bMD51TEXTEl-Bachá et al 1998.pdf.txtEl-Bachá et al 1998.pdf.txtExtracted texttext/plain8https://repositorio.ufba.br/bitstream/ri/7194/3/El-Bach%c3%a1%20et%20al%201998.pdf.txt8d1b69dd9bdc9df4a8073c7a8193c7afMD53ri/71942022-07-05 14:03:23.267oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:23Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Dietary antioxidant deficiency facilitates cortical spreading depression induced by photoactivated riboflavin
title Dietary antioxidant deficiency facilitates cortical spreading depression induced by photoactivated riboflavin
spellingShingle Dietary antioxidant deficiency facilitates cortical spreading depression induced by photoactivated riboflavin
El-Bachá, Ramon dos Santos
Ascorbic acid
Vitamin E
Free Radicals
Ribloflavin
Spreading dpression
Superoxide
title_short Dietary antioxidant deficiency facilitates cortical spreading depression induced by photoactivated riboflavin
title_full Dietary antioxidant deficiency facilitates cortical spreading depression induced by photoactivated riboflavin
title_fullStr Dietary antioxidant deficiency facilitates cortical spreading depression induced by photoactivated riboflavin
title_full_unstemmed Dietary antioxidant deficiency facilitates cortical spreading depression induced by photoactivated riboflavin
title_sort Dietary antioxidant deficiency facilitates cortical spreading depression induced by photoactivated riboflavin
author El-Bachá, Ramon dos Santos
author_facet El-Bachá, Ramon dos Santos
Lima Filho, José L. de
Guedes, Rubem C. A.
author_role author
author2 Lima Filho, José L. de
Guedes, Rubem C. A.
author2_role author
author
dc.contributor.author.fl_str_mv El-Bachá, Ramon dos Santos
Lima Filho, José L. de
Guedes, Rubem C. A.
El-Bachá, Ramon dos Santos
Lima Filho, José L. de
Guedes, Rubem C. A.
dc.subject.por.fl_str_mv Ascorbic acid
Vitamin E
Free Radicals
Ribloflavin
Spreading dpression
Superoxide
topic Ascorbic acid
Vitamin E
Free Radicals
Ribloflavin
Spreading dpression
Superoxide
description Trabalho resultante do mestrado do primeiro autor.
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2012-11-13T17:13:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7194
dc.identifier.issn.none.fl_str_mv 1028415X
dc.identifier.number.pt_BR.fl_str_mv v. 1 , n. 3
identifier_str_mv 1028415X
v. 1 , n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/7194
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Overseas Publishers Association
publisher.none.fl_str_mv Overseas Publishers Association
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
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reponame_str Repositório Institucional da UFBA
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