Ivermectin and albendazole withdrawal period in goat milk

• Autor(a) principal: Santos,Patrícia Silva
• Data de Publicação: 2019
• Outros Autores: Cruz,Jurandir Ferreira da, Santos,José Soares dos, Mottin,Vanessa Daniele, Teixeira Neto,Milton Rezende, Souza,Jennifer Figueredo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Saúde e Produção Animal
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-99402019000100800
• topic: HPLC; goat milk; residues

SUMMARY Theaimthis study was to determine the excretion profile of albendazole and ivermectin residues in milk from goats submitted to antiparasitic treatment. Twenty-four Brazilianmongrel lactating and pluriparous goats, maintained extensively on native pasture were orally treatedwith albendazole or ivermectin. Milk samples were collected before and after vermifuges application, in the days 0, 2, 3 e 4 to albendazole and 0, 3, 7, 14, 21, 28, 35 and 42 to ivermectin. The vermifuges residues were detected by high performance liquid cromatography with ultravioletdetector. The amount of residues contained in themilk was decreasing in function of time. The mean daily rates of decrease of albendazole residues were 63.34%, 40.18 and 100.0%, from the 2ndto the 4thday, respectively; on the 3rdday after treatment, 50% of the samples showed concentrations ≥ 47.61 μg.mL–1, and on the 4thday, no sample had albendazole residue. The amount excreted of ivermectin was similar between the 3rdand 21stday when all samples presented values ≥ 51.90 μg.mL-1; on the 35th day, 50% of the samples showed values above of recommended levels, and on the 42nd day, no sample had detectable ivermectin residue. In conclusion, the milk of Brazilian mongrel goats treated orally with albendazole or ivermectin does not contain its respective residues in detectable amounts from the 4th and 42nddays, respectively, after antiparasitic treatment.