Effect of oral antihypertensive drugs on biochemical dosages in the elderly

• Autor(a) principal: Carvalho, Maria Elizana Martins de Meneses
• Data de Publicação: 2016
• Outros Autores: Alves, Eucário Leite Monteiro, Martins, Maria do Carmo de Carvalho e
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Rev Rene (Online)
• Texto Completo: http://periodicos.ufc.br/rene/article/view/18850
• topic: Aged; Antihypertensive Agents; Drug-Related Side Effects and Adverse Reactions.

Objective: to compare serum levels of uric acid, glucose, potassium and sodium in elderly users and non-users of oral antihypertensive drugs. Methods: observational, case-control study, including 232 elderly people with mean age 68.9 ± 7.4 years, of which 116 use and 116 do not use oral antihypertensive drugs, of both genders, non-diabetic and with no renal disease. After venous blood collection, glucose and uric acid were measured by colorimetric method; and sodium and potassium by the ion-selective electrode method. Results: there was an association between use of antihypertensive drugs and elevations in serum uric acid levels (p=0.040). And, among the classes, diuretic drugs demonstrated in this study relation with changes in uric acid levels (p=0.02) when compared to the other classes. Conclusion: the use of antihypertensive drugs, especially diuretics, has been associated with an increase in serum uric acid levels in hypertensive users of oral antihypertensive drugs.