Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata

Detalhes bibliográficos
Autor(a) principal: Cunha, Gracielle Oliveira Sabbag
Data de Publicação: 2020
Outros Autores: Terezan, Ana Paula, Matos, Andreia Pereira, Burger, Marcela Carmen de Melo, Vieira, Paulo Cezar, Fernandes, João Batista, Fernandes da Silva, Maria Fátima das Graças, Menezes, Antônio Carlos Severo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Brasiliensis (Online)
Texto Completo: http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/249
Resumo: This study evaluated the antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata (Melastomataceae) against five microorganisms: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6623), Pseudomonas aeruginosa (ATCC 15442), and Candida albicans (ATCC 10231). The isomeric mixture of ursolic and oleanolic acids was active against S. aureus (MIC = 250 μg mL-1) and against E. coli, B. subtilis, and P. aeruginosa (MIC = 500 μg mL-1). The flavone 5,6,7-trihydroxy-4’-methoxyflavone and the methyl esters, semisynthetic derivatives of a mixture of ursolic and oleanolic acids, showed no activity against the tested microorganisms. These results suggest that the carboxyl group present in the triterpenes may contribute to antimicrobial activity.
id UFCG-6_27d45a8ed60661598e6114e9de726cc9
oai_identifier_str oai:ActaBra.revistas.ufcg.edu.br:article/249
network_acronym_str UFCG-6
network_name_str Acta Brasiliensis (Online)
repository_id_str
spelling Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata Atividade antimicrobiana de compostos isolados e derivados semissintéticos de Miconia ferruginataThis study evaluated the antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata (Melastomataceae) against five microorganisms: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6623), Pseudomonas aeruginosa (ATCC 15442), and Candida albicans (ATCC 10231). The isomeric mixture of ursolic and oleanolic acids was active against S. aureus (MIC = 250 μg mL-1) and against E. coli, B. subtilis, and P. aeruginosa (MIC = 500 μg mL-1). The flavone 5,6,7-trihydroxy-4’-methoxyflavone and the methyl esters, semisynthetic derivatives of a mixture of ursolic and oleanolic acids, showed no activity against the tested microorganisms. These results suggest that the carboxyl group present in the triterpenes may contribute to antimicrobial activity.Este estudo descreve a avaliação da atividade antimicrobiana de compostos isolados e derivados semissintéticos de Miconia ferruginata (Melastomataceae) contra cinco microorganismos: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6623), Pseudomonas aeruginosa (ATCC 15442) and Candida albicans (ATCC 10231). A mistura isomérica dos ácidos ursólico e oleanólico foi ativa contra S. aureus (CIM = 250 μg mL-1) e contra E. coli, B. subtilis e P. aeruginosa (CIM = 500 μg mL-1). A flavona 5,6,7-trihidroxi-4’-metóxiflavona e os ésteres metílicos, derivados semissintéticos da mistura dos ácidos ursólico e oleanólico, não apresentaram atividade contra os microrganismos testados. Estes resultados sugerem que o grupo carboxila presente nos triterpenos podem contribuir para a atividade antimicrobiana.Universidade Federal de Campina Grande - UFCG2020-01-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/24910.22571/2526-4338249Acta Brasiliensis; Vol 4 No 1 (2020): Acta Brasiliensis; 49-52Acta Brasiliensis; Vol 4 No 1 (2020): Acta Brasiliensis; 49-52Acta Brasiliensis; Vol 4 No 1 (2020): Acta Brasiliensis; 49-522526-43382526-432Xreponame:Acta Brasiliensis (Online)instname:Universidade Federal de Campina Grande (UFCG)instacron:UFCGenghttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/249/87Copyright (c) 2020 Acta Brasiliensisinfo:eu-repo/semantics/openAccessCunha, Gracielle Oliveira SabbagTerezan, Ana PaulaMatos, Andreia PereiraBurger, Marcela Carmen de MeloVieira, Paulo CezarFernandes, João BatistaFernandes da Silva, Maria Fátima das GraçasMenezes, Antônio Carlos Severo2021-07-12T20:03:44Zoai:ActaBra.revistas.ufcg.edu.br:article/249Revistahttp://revistas.ufcg.edu.br/ActaBraPUBhttp://revistas.ufcg.edu.br/ActaBra/index.php/actabra/oaiactabrasiliensis@gmail.com || actabrasiliensis@gmail.com2526-432X2526-4338opendoar:2021-07-12T20:03:44Acta Brasiliensis (Online) - Universidade Federal de Campina Grande (UFCG)false
dc.title.none.fl_str_mv Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata

Atividade antimicrobiana de compostos isolados e derivados semissintéticos de Miconia ferruginata
title Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata
spellingShingle Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata
Cunha, Gracielle Oliveira Sabbag
title_short Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata
title_full Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata
title_fullStr Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata
title_full_unstemmed Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata
title_sort Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata
author Cunha, Gracielle Oliveira Sabbag
author_facet Cunha, Gracielle Oliveira Sabbag
Terezan, Ana Paula
Matos, Andreia Pereira
Burger, Marcela Carmen de Melo
Vieira, Paulo Cezar
Fernandes, João Batista
Fernandes da Silva, Maria Fátima das Graças
Menezes, Antônio Carlos Severo
author_role author
author2 Terezan, Ana Paula
Matos, Andreia Pereira
Burger, Marcela Carmen de Melo
Vieira, Paulo Cezar
Fernandes, João Batista
Fernandes da Silva, Maria Fátima das Graças
Menezes, Antônio Carlos Severo
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cunha, Gracielle Oliveira Sabbag
Terezan, Ana Paula
Matos, Andreia Pereira
Burger, Marcela Carmen de Melo
Vieira, Paulo Cezar
Fernandes, João Batista
Fernandes da Silva, Maria Fátima das Graças
Menezes, Antônio Carlos Severo
description This study evaluated the antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata (Melastomataceae) against five microorganisms: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6623), Pseudomonas aeruginosa (ATCC 15442), and Candida albicans (ATCC 10231). The isomeric mixture of ursolic and oleanolic acids was active against S. aureus (MIC = 250 μg mL-1) and against E. coli, B. subtilis, and P. aeruginosa (MIC = 500 μg mL-1). The flavone 5,6,7-trihydroxy-4’-methoxyflavone and the methyl esters, semisynthetic derivatives of a mixture of ursolic and oleanolic acids, showed no activity against the tested microorganisms. These results suggest that the carboxyl group present in the triterpenes may contribute to antimicrobial activity.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-20
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/249
10.22571/2526-4338249
url http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/249
identifier_str_mv 10.22571/2526-4338249
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://revistas.ufcg.edu.br/ActaBra/index.php/actabra/article/view/249/87
dc.rights.driver.fl_str_mv Copyright (c) 2020 Acta Brasiliensis
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Acta Brasiliensis
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Campina Grande - UFCG
publisher.none.fl_str_mv Universidade Federal de Campina Grande - UFCG
dc.source.none.fl_str_mv Acta Brasiliensis; Vol 4 No 1 (2020): Acta Brasiliensis; 49-52
Acta Brasiliensis; Vol 4 No 1 (2020): Acta Brasiliensis; 49-52
Acta Brasiliensis; Vol 4 No 1 (2020): Acta Brasiliensis; 49-52
2526-4338
2526-432X
reponame:Acta Brasiliensis (Online)
instname:Universidade Federal de Campina Grande (UFCG)
instacron:UFCG
instname_str Universidade Federal de Campina Grande (UFCG)
instacron_str UFCG
institution UFCG
reponame_str Acta Brasiliensis (Online)
collection Acta Brasiliensis (Online)
repository.name.fl_str_mv Acta Brasiliensis (Online) - Universidade Federal de Campina Grande (UFCG)
repository.mail.fl_str_mv actabrasiliensis@gmail.com || actabrasiliensis@gmail.com
_version_ 1792204524147965952

Registros relacionados