Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/3578 |
Resumo: | Drug induced gingival overgrowth (DIGO) is an adverse effect associated with the chronic use of three main drugs: phenytoin, an anticonvulsant, cyclosporin, an immunosuppressant drug and the pharmacological agents known as calcium channel blockers (CCB). Nifedipine is a calcium channel blocker, which because of its strong vessel dilating action has become widely used in cardiotherapy, in particular for the control of arterial hypertension. The aim of this study is to evaluate the microscopic characteristics and the epithelial proliferation index of gingival tissue in patients undergoing chronic treatment with nifedipine. To do so, twenty samples of gingival tissue of patients undergoing chronic treatment with nifedipine were obtained. The majority of these patients did not present clinically detectable gingival overgrowth. For comparative purposes, nine samples of gingival tissues of healthy patients who did not use drugs associated with gingival overgrowth (control) were used. The samples were microscopically analyzed using hematoxylin-eosin staining, to determine the size of the epithelial rete pegs. To carry out the epithelial proliferation index evaluation, a cellular identification of the Ki-67 and B1 Cyclin proteins was done using the immunohistochemical technique (streptavidin-biotin-peroxidase), as well as the quantification of positive cells (+cells) in mm².The results showed that the epithelial tissue of nifedipine users has considerably longer rete pegs that of the control group (Mann-Whitney, p=0.02). However, with regard to the proliferating activity of the keratinocytes, no significant difference was observed between the two groups (Mann-Whitney, p>0.05). The findings show that the microscopic alterations observed in the epithelium of nifedipine users are not caused by the mitotic activity of the keratinocytes but taking data from the literature into consideration, it is suggested that this increase might be caused by an inhibition of apoptosis rate of these same cells. |
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Mendonca, Elismauro Francisco dehttp://lattes.cnpq.br/2305019128015847Batista, Aline CarvalhoMendonça, Elismauro Francisco deGuimarães, Maria do Carmo MachadoGuilherme, Adérico Santanahttp://lattes.cnpq.br/1749024668988981Castro, Luciano Alberto de2014-11-07T17:14:21Z2006-02-28Castro, Luciano Alberto de. Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina. 2006. 85 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Goiás, Goiânia, 2006.http://repositorio.bc.ufg.br/tede/handle/tede/3578Drug induced gingival overgrowth (DIGO) is an adverse effect associated with the chronic use of three main drugs: phenytoin, an anticonvulsant, cyclosporin, an immunosuppressant drug and the pharmacological agents known as calcium channel blockers (CCB). Nifedipine is a calcium channel blocker, which because of its strong vessel dilating action has become widely used in cardiotherapy, in particular for the control of arterial hypertension. The aim of this study is to evaluate the microscopic characteristics and the epithelial proliferation index of gingival tissue in patients undergoing chronic treatment with nifedipine. To do so, twenty samples of gingival tissue of patients undergoing chronic treatment with nifedipine were obtained. The majority of these patients did not present clinically detectable gingival overgrowth. For comparative purposes, nine samples of gingival tissues of healthy patients who did not use drugs associated with gingival overgrowth (control) were used. The samples were microscopically analyzed using hematoxylin-eosin staining, to determine the size of the epithelial rete pegs. To carry out the epithelial proliferation index evaluation, a cellular identification of the Ki-67 and B1 Cyclin proteins was done using the immunohistochemical technique (streptavidin-biotin-peroxidase), as well as the quantification of positive cells (+cells) in mm².The results showed that the epithelial tissue of nifedipine users has considerably longer rete pegs that of the control group (Mann-Whitney, p=0.02). However, with regard to the proliferating activity of the keratinocytes, no significant difference was observed between the two groups (Mann-Whitney, p>0.05). The findings show that the microscopic alterations observed in the epithelium of nifedipine users are not caused by the mitotic activity of the keratinocytes but taking data from the literature into consideration, it is suggested that this increase might be caused by an inhibition of apoptosis rate of these same cells.O crescimento gengival induzido por drogas (CGID) é um efeito adverso associado ao uso crônico de três medicamentos principais: a fenitoína, um anticonvulsivante, a ciclosporina, uma droga imunossupressora e os agentes farmacológicos conhecidos como bloqueadores dos canais de cálcio (BCC). A nifedipina é um bloqueador dos canais de cálcio que, por sua potente ação vasodilatadora, tornou-se uma droga largamente utilizada em cardioterapia, especialmente, para controle da hipertensão arterial. O presente trabalho teve como objetivo avaliar as características microscópicas e o índice proliferativo epitelial do tecido gengival de pacientes sob terapia crônica com nifedipina. Para este fim, foram obtidas vinte amostras de tecido gengival de usuários crônicos de nifedipina, sendo que, a maioria dos pacientes não apresentava CG clinicamente detectável. Para fins comparativos, foram utilizadas nove amostras de tecido gengival de pacientes saudáveis e não usuários de drogas indutoras de CG (controle). As amostras foram avaliadas microscopicamente, por meio da coloração de hematoxilina-eosina, quanto ao tamanho das cristas epiteliais. Para a avaliação do índice proliferativo epitelial, foi realizada a identificação celular das proteínas Ki-67 e Ciclina B1 pela técnica da imunoistoquímica (streptavidina-biotina-peroxidase), bem como a quantificação das células positivas (células +) por mm2. Os resultados revelaram que os pacientes usuários de nifedipina exibiram um tecido epitelial com cristas significativamente mais longas do que os pacientes do grupo controle (Mann-Whitney, p=0,02). No entanto, quanto à atividade proliferativa dos queratinócitos, não pôde ser observada diferença significante entre os dois grupos (Mann-Whitney, p>0,05). Os achados revelaram que as alterações microscópicas observadas no epitélio de pacientes usuários de nifedipina não ocorreram por aumento da atividade mitótica dos queratinócitos, mas considerando dados da literatura, sugere-se que este aumento possa ocorrer devido a uma inibição da taxa de apoptose destas células.Submitted by Jaqueline Silva (jtas29@gmail.com) on 2014-11-07T17:14:00Z No. of bitstreams: 2 Dissertacao - Luciano Alberto de Castro - 2006.pdf: 817678 bytes, checksum: e83324d3753e3c2449197b0379e4981a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Jaqueline Silva (jtas29@gmail.com) on 2014-11-07T17:14:21Z (GMT) No. of bitstreams: 2 Dissertacao - Luciano Alberto de Castro - 2006.pdf: 817678 bytes, checksum: e83324d3753e3c2449197b0379e4981a (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2014-11-07T17:14:21Z (GMT). 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dc.title.por.fl_str_mv |
Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina |
title |
Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina |
spellingShingle |
Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina Castro, Luciano Alberto de Efeitos adversos Proliferação de células Apoptose Nifedipina Adverse effect Cell proliferation Apoptosis Nifedipine CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina |
title_full |
Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina |
title_fullStr |
Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina |
title_full_unstemmed |
Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina |
title_sort |
Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina |
author |
Castro, Luciano Alberto de |
author_facet |
Castro, Luciano Alberto de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Mendonca, Elismauro Francisco de |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/2305019128015847 |
dc.contributor.advisor-co1.fl_str_mv |
Batista, Aline Carvalho |
dc.contributor.referee1.fl_str_mv |
Mendonça, Elismauro Francisco de |
dc.contributor.referee2.fl_str_mv |
Guimarães, Maria do Carmo Machado |
dc.contributor.referee3.fl_str_mv |
Guilherme, Adérico Santana |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1749024668988981 |
dc.contributor.author.fl_str_mv |
Castro, Luciano Alberto de |
contributor_str_mv |
Mendonca, Elismauro Francisco de Batista, Aline Carvalho Mendonça, Elismauro Francisco de Guimarães, Maria do Carmo Machado Guilherme, Adérico Santana |
dc.subject.por.fl_str_mv |
Efeitos adversos Proliferação de células Apoptose Nifedipina |
topic |
Efeitos adversos Proliferação de células Apoptose Nifedipina Adverse effect Cell proliferation Apoptosis Nifedipine CIENCIAS DA SAUDE::ODONTOLOGIA |
dc.subject.eng.fl_str_mv |
Adverse effect Cell proliferation Apoptosis Nifedipine |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
Drug induced gingival overgrowth (DIGO) is an adverse effect associated with the chronic use of three main drugs: phenytoin, an anticonvulsant, cyclosporin, an immunosuppressant drug and the pharmacological agents known as calcium channel blockers (CCB). Nifedipine is a calcium channel blocker, which because of its strong vessel dilating action has become widely used in cardiotherapy, in particular for the control of arterial hypertension. The aim of this study is to evaluate the microscopic characteristics and the epithelial proliferation index of gingival tissue in patients undergoing chronic treatment with nifedipine. To do so, twenty samples of gingival tissue of patients undergoing chronic treatment with nifedipine were obtained. The majority of these patients did not present clinically detectable gingival overgrowth. For comparative purposes, nine samples of gingival tissues of healthy patients who did not use drugs associated with gingival overgrowth (control) were used. The samples were microscopically analyzed using hematoxylin-eosin staining, to determine the size of the epithelial rete pegs. To carry out the epithelial proliferation index evaluation, a cellular identification of the Ki-67 and B1 Cyclin proteins was done using the immunohistochemical technique (streptavidin-biotin-peroxidase), as well as the quantification of positive cells (+cells) in mm².The results showed that the epithelial tissue of nifedipine users has considerably longer rete pegs that of the control group (Mann-Whitney, p=0.02). However, with regard to the proliferating activity of the keratinocytes, no significant difference was observed between the two groups (Mann-Whitney, p>0.05). The findings show that the microscopic alterations observed in the epithelium of nifedipine users are not caused by the mitotic activity of the keratinocytes but taking data from the literature into consideration, it is suggested that this increase might be caused by an inhibition of apoptosis rate of these same cells. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006-02-28 |
dc.date.accessioned.fl_str_mv |
2014-11-07T17:14:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Castro, Luciano Alberto de. Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina. 2006. 85 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Goiás, Goiânia, 2006. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/3578 |
identifier_str_mv |
Castro, Luciano Alberto de. Análise microscópica e da imunoexpressão dos marcadores de proliferação celular Ki-67 e Ciclina B1 no epitélio gengival de pacientes sob terapia com nifedipina. 2006. 85 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Goiás, Goiânia, 2006. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/3578 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
-2325576619034292269 |
dc.relation.confidence.fl_str_mv |
600 600 600 |
dc.relation.department.fl_str_mv |
-5569154581575113691 |
dc.relation.cnpq.fl_str_mv |
-2070498469879244349 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Odontologia (FO) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Faculdade de Odontologia - FO (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Repositório Institucional da UFG |
collection |
Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/733f787f-718c-477e-bb5d-f1f39ec8238b/download http://repositorio.bc.ufg.br/tede/bitstreams/c2be85d2-806c-4ed0-ae6a-a436a3c66100/download http://repositorio.bc.ufg.br/tede/bitstreams/c2c1c990-e86d-42ee-bfd7-696864c76c1c/download http://repositorio.bc.ufg.br/tede/bitstreams/80996c3f-2cee-4ead-a15d-25cc726e7452/download http://repositorio.bc.ufg.br/tede/bitstreams/7dbfeb5a-6b4c-409e-9da2-c215c3fc2b63/download http://repositorio.bc.ufg.br/tede/bitstreams/86920e06-154b-46ca-9531-965d44d07e94/download http://repositorio.bc.ufg.br/tede/bitstreams/33027c69-04fc-4563-8eb6-728636dc20e1/download |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f 1e0094e9d8adcf16b18effef4ce7ed83 9da0b6dfac957114c6a7714714b86306 e83324d3753e3c2449197b0379e4981a 27b10b8fed06b92f3c83886ec8b15c8b 104c223165a6f94eece9426834d78437 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798044412338503680 |