Doença periodontal e glomerulonefrite em cães

• Autor(a) principal: Meneses, Thaís Domingos
• Data de Publicação: 2013
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/3362
• topic: Bacteremia; Imunocomplexo; Nefropatia; Patologia clínica; Bacteremia; Immune complex; Nephropathy; Clinical pathology; PATOLOGIA ANIMAL::PATOLOGIA CLINICA ANIMAL

Studies have shown that periodontal disease affects approximately 85 % of dogs older than three years of age, being responsible for inflammation and destruction of the tooth supporting tissues. This study aimed at evaluating the relationship between periodontal disease and glomerulonephritis in dogs. We evaluated and classified 61 dogs with periodontal disease into groups according to the severity of the case. Clinical evaluation consisted of complete blood count, serum biochemistry (urea, creatinine, total protein, albumin, cholesterol and phosphorus), blood pressure measurement, urinalysis and urinary biochemistry (GGT, ALP, protein and creatinine), and determination of urine protein:creatinine ratio. Of the 14 dogs with glomerulonephritis compatible alterations at the first exam, nine were submitted to a second laboratory evaluation, after periodontal treatment, in order to verify if they continued with persistent proteinuria associated with inactive urinary sediment. Of these, eight dogs continued to show abnormalities suggestive of glomerulonephritis, even after periodontal treatment. The diagnostic tools used in this study allowed to identify and characterize both glomerulonephritis secondary to periodontal disease, establishing a relationship between them and tubular damage and urinary tract infections that occur concurrently with periodontal disease. These findings help to establish the use of early markers of kidney injury in clinical laboratory tests, in order to prevent the process evolution, promoting animal welfare and contributing to increase longevity of dogs.