Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/4139 |
Resumo: | Introduction: Chlamydia trachomatis is the bacteria responsible for the most prevalent sexually transmitted disease worldwide. Most of the infections in men and women is asymptomatic and when undiagnosed and untreated may reach the joints causing not only arthritis, but also other acknowledged complications related to the female reproductive system. Objective: To investigate C. trachomatis DNA in the urine and synovial fluid from patients with spondyloarthropathies (SpA) and rheumatoid arthritis (RA) and evaluate serum anti-C. trachomatisIgG and IgM antibodies. Methods: The population consisted of 15 patients with spondyloarthropathies, being nine with undifferentiated spondyloarthropathy (US) and six with reactive arthritis (ReA) (group I), and 15 patients with rheumatoid arthritis (RA) (group II). The chlamydial DNA was assessed in synovial fluid and urine samples of all patients by Amplicor PCR. The anti-chlamydial IgG and IgM antibodies were quantified through indirect imunofluorescence (IIF), while 15 patients of group I were typed for HLA-B27 by the use of flow citometry. Social demographical data and all information on sexual behavior and presence of symptoms were collected through a (questionnaire in the form of) an interview. Results: C. trachomatis DNA was found in only one synovial fluid sample from patient with ReA (6,7%). In two patients with RA, chlamydial DNA was identified in the urine sample (13,3%). The anti-chlamydial IgG antibodies were present in eight patients of the population studied; being three patients from group I (20%), and five from group II (33,3%). The greatest titer of this antibody 1/256 was associated with the presence of chlamydial DNA in a patient from group II. The IgM antibody was not detected in any of the samples from both groups. Four individuals from group II (26,7%) were HLA-B27 positive and its presence was 16 related to sacroiliitis. Conclusion: The results in this study show that in patients with spondyloarthropathies and rheumatoid arthritis, presenting a picture of articular activity one might not exclude C. trachomatisas the triggering agent. |
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Alves, Maria de Fátima Costahttp://lattes.cnpq.br/1412047788155346Ximenes, Antonio CarlosFernandez, Rafael Navarrete2015-02-12T17:39:02Z2004-04-20FERNANDEZ, Rafael Navarrete, Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide. 2004. 86 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2004.http://repositorio.bc.ufg.br/tede/handle/tede/4139Introduction: Chlamydia trachomatis is the bacteria responsible for the most prevalent sexually transmitted disease worldwide. Most of the infections in men and women is asymptomatic and when undiagnosed and untreated may reach the joints causing not only arthritis, but also other acknowledged complications related to the female reproductive system. Objective: To investigate C. trachomatis DNA in the urine and synovial fluid from patients with spondyloarthropathies (SpA) and rheumatoid arthritis (RA) and evaluate serum anti-C. trachomatisIgG and IgM antibodies. Methods: The population consisted of 15 patients with spondyloarthropathies, being nine with undifferentiated spondyloarthropathy (US) and six with reactive arthritis (ReA) (group I), and 15 patients with rheumatoid arthritis (RA) (group II). The chlamydial DNA was assessed in synovial fluid and urine samples of all patients by Amplicor PCR. The anti-chlamydial IgG and IgM antibodies were quantified through indirect imunofluorescence (IIF), while 15 patients of group I were typed for HLA-B27 by the use of flow citometry. Social demographical data and all information on sexual behavior and presence of symptoms were collected through a (questionnaire in the form of) an interview. Results: C. trachomatis DNA was found in only one synovial fluid sample from patient with ReA (6,7%). In two patients with RA, chlamydial DNA was identified in the urine sample (13,3%). The anti-chlamydial IgG antibodies were present in eight patients of the population studied; being three patients from group I (20%), and five from group II (33,3%). The greatest titer of this antibody 1/256 was associated with the presence of chlamydial DNA in a patient from group II. The IgM antibody was not detected in any of the samples from both groups. Four individuals from group II (26,7%) were HLA-B27 positive and its presence was 16 related to sacroiliitis. Conclusion: The results in this study show that in patients with spondyloarthropathies and rheumatoid arthritis, presenting a picture of articular activity one might not exclude C. trachomatisas the triggering agent.Introdução: A Chlamydia trachomatis é a bactéria responsável pela doença sexualmente transmissível mais prevalente no mundo. A maioria das infecções em homens e mulheres é assintomática e, quando não diagnosticada e tratada, pode alcançar as articulações e causar artrite, isto sem mencionar outras complicações conhecidas relacionadas ao aparelho reprodutor feminino. Objetivos: Pesquisar o DNA de C. trachomatis no líquido sinovial e urina, em pacientes com espondiloartropatias e artrite reumatóide (AR) e avaliar a presença de anticorpos séricos IgG e IgM anti-C. trachomatis nestes dois grupos de doenças. Identificar o antígeno HLA-B27 em pacientes com espondiloartropatias. Metodologia: A população do estudo consistiu de 15 pacientes com espondiloartropatias: nove com espondiloartropatia indiferenciada (EI) e seis com artrite reativa (ARe) (grupo I) e 15 pacientes com AR (grupo II). O DNA clamidial foi pesquisado em amostras de líquido sinovial e urina de todos eles empregandose a PCR (Amplicor Roche). Os anticorpos IgG e IgM anti-clamidiais foram quantificados por imunofluorescência indireta (IFI), enquanto o HLA-B27 foi tipado em 15 pacientes do grupo I por citometria de fluxo. Os dados sócio-demográficos, de comportamento sexual e presença de sintomas foram obtidos através de questionário na forma de entrevista. Resultados: O DNA da C. trachomatis foi evidenciado apenas em uma amostra de líquido sinovial do grupo I (6,7%), sendo o paciente portador de ARe. Em dois pacientes com AR, o DNA de clamidial foi identificado na urina (13,3%). Os anticorpos IgG anti-clamidiais estavam presentes em oito pacientes da população estudada, três do grupo I (20%) e cinco do grupo II (33,3%). O maior título desse anticorpo (1/256) associou-se com a presença do DNA clamidial na urina de um paciente do grupo II. O anticorpo IgM não foi detectado em nenhuma amostra 14 dos dois grupos. O antígeno HLA-B27 foi positivo em quatro indivíduos do grupo II (26,7%) e sua presença relacionou-se com sacroiliite. Conclusões: Os resultados desse estudo indicam que em portadores de espondiloartropatias e artrite reumatóide, com quadro articular em atividade, a C. trachomatisnão pode ser excluída como agente desencadeador.Submitted by Erika Demachki (erikademachki@gmail.com) on 2015-02-12T17:38:37Z No. of bitstreams: 2 Dissertação - Rafael Navarrete Fernandez - 2004.pdf: 737923 bytes, checksum: 9f9c7b498798d7f0e65f37b958ef6d70 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2015-02-12T17:38:59Z (GMT) No. of bitstreams: 2 Dissertação - Rafael Navarrete Fernandez - 2004.pdf: 737923 bytes, checksum: 9f9c7b498798d7f0e65f37b958ef6d70 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2015-02-12T17:39:02Z (GMT). No. of bitstreams: 2 Dissertação - Rafael Navarrete Fernandez - 2004.pdf: 737923 bytes, checksum: 9f9c7b498798d7f0e65f37b958ef6d70 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2004-04-20application/pdfhttp://repositorio.bc.ufg.br/tede/retrieve/16803/Disserta%c3%a7%c3%a3o%20-%20Rafael%20Navarrete%20Fernandez%20-%202004.pdf.jpgporUniversidade Federal de GoiásPrograma de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP)UFGBrasilInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessChlamydia trachomatisPCREspondiloartropatiasArtrite reumatóideSpondyloarthropathiesRheumatoid arthritisCLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIASDetecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóideDetection of Chlamydia trachomatis in spondyloarthropathies and rheumatoid arthritisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis6085308344741430434600600600-77690114445645562881767748423488408711reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.eng.fl_str_mv |
Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide |
dc.title.alternative.eng.fl_str_mv |
Detection of Chlamydia trachomatis in spondyloarthropathies and rheumatoid arthritis |
title |
Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide |
spellingShingle |
Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide Fernandez, Rafael Navarrete Chlamydia trachomatis PCR Espondiloartropatias Artrite reumatóide Spondyloarthropathies Rheumatoid arthritis CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS |
title_short |
Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide |
title_full |
Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide |
title_fullStr |
Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide |
title_full_unstemmed |
Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide |
title_sort |
Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide |
author |
Fernandez, Rafael Navarrete |
author_facet |
Fernandez, Rafael Navarrete |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Alves, Maria de Fátima Costa |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1412047788155346 |
dc.contributor.advisor-co1.fl_str_mv |
Ximenes, Antonio Carlos |
dc.contributor.author.fl_str_mv |
Fernandez, Rafael Navarrete |
contributor_str_mv |
Alves, Maria de Fátima Costa Ximenes, Antonio Carlos |
dc.subject.por.fl_str_mv |
Chlamydia trachomatis PCR Espondiloartropatias Artrite reumatóide |
topic |
Chlamydia trachomatis PCR Espondiloartropatias Artrite reumatóide Spondyloarthropathies Rheumatoid arthritis CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS |
dc.subject.eng.fl_str_mv |
Spondyloarthropathies Rheumatoid arthritis |
dc.subject.cnpq.fl_str_mv |
CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS |
description |
Introduction: Chlamydia trachomatis is the bacteria responsible for the most prevalent sexually transmitted disease worldwide. Most of the infections in men and women is asymptomatic and when undiagnosed and untreated may reach the joints causing not only arthritis, but also other acknowledged complications related to the female reproductive system. Objective: To investigate C. trachomatis DNA in the urine and synovial fluid from patients with spondyloarthropathies (SpA) and rheumatoid arthritis (RA) and evaluate serum anti-C. trachomatisIgG and IgM antibodies. Methods: The population consisted of 15 patients with spondyloarthropathies, being nine with undifferentiated spondyloarthropathy (US) and six with reactive arthritis (ReA) (group I), and 15 patients with rheumatoid arthritis (RA) (group II). The chlamydial DNA was assessed in synovial fluid and urine samples of all patients by Amplicor PCR. The anti-chlamydial IgG and IgM antibodies were quantified through indirect imunofluorescence (IIF), while 15 patients of group I were typed for HLA-B27 by the use of flow citometry. Social demographical data and all information on sexual behavior and presence of symptoms were collected through a (questionnaire in the form of) an interview. Results: C. trachomatis DNA was found in only one synovial fluid sample from patient with ReA (6,7%). In two patients with RA, chlamydial DNA was identified in the urine sample (13,3%). The anti-chlamydial IgG antibodies were present in eight patients of the population studied; being three patients from group I (20%), and five from group II (33,3%). The greatest titer of this antibody 1/256 was associated with the presence of chlamydial DNA in a patient from group II. The IgM antibody was not detected in any of the samples from both groups. Four individuals from group II (26,7%) were HLA-B27 positive and its presence was 16 related to sacroiliitis. Conclusion: The results in this study show that in patients with spondyloarthropathies and rheumatoid arthritis, presenting a picture of articular activity one might not exclude C. trachomatisas the triggering agent. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004-04-20 |
dc.date.accessioned.fl_str_mv |
2015-02-12T17:39:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERNANDEZ, Rafael Navarrete, Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide. 2004. 86 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2004. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/4139 |
identifier_str_mv |
FERNANDEZ, Rafael Navarrete, Detecção do DNA de Chlamydia trachomatis em espondiloartopatias e artrite reumatóide. 2004. 86 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2004. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/4139 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
6085308344741430434 |
dc.relation.confidence.fl_str_mv |
600 600 600 |
dc.relation.department.fl_str_mv |
-7769011444564556288 |
dc.relation.cnpq.fl_str_mv |
1767748423488408711 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
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UFG |
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UFG |
reponame_str |
Repositório Institucional da UFG |
collection |
Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/d7a5dfb4-d8f0-44c9-9a85-40579efc678a/download http://repositorio.bc.ufg.br/tede/bitstreams/8731f8ac-7b22-4f02-9bd5-c2af7a387b56/download http://repositorio.bc.ufg.br/tede/bitstreams/2811f937-b345-41fe-97e2-8805905868fc/download http://repositorio.bc.ufg.br/tede/bitstreams/06b18621-f9b3-4523-b0fb-878a8b3537f3/download http://repositorio.bc.ufg.br/tede/bitstreams/c3a19cc4-5e64-49a0-b7d5-c3335fccd530/download http://repositorio.bc.ufg.br/tede/bitstreams/0e5bbd34-7541-4843-98e1-153ebd09cbcc/download http://repositorio.bc.ufg.br/tede/bitstreams/5abf8b3f-da4e-4fd0-b639-38e36d59167e/download |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f b292a83e42bd8ad62533bba1395b83ff 9da0b6dfac957114c6a7714714b86306 9f9c7b498798d7f0e65f37b958ef6d70 e2e2e4ba1e6a412d8817748129f428ba f3e5697361d30816670d85bb3d4076f5 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798044402961088512 |