Co-treatment of wounds in rabbit skin with equine platelet-rich plasma and a commercial ointment accelerates healing
Main Author: | |
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Publication Date: | 2020 |
Other Authors: | , , , |
Format: | Article |
Language: | por eng |
Source: | Ciência animal brasileira (Online) |
Download full: | https://revistas.ufg.br/vet/article/view/56274 |
Summary: | Autologous platelet-rich plasma (PRP) is beneficial in the healing process of reconstructive surgeries, contributing to the stimulation of angiogenesis; however, heterologous plasma has been shown to be more effective. The objective of this study was to verify, by macro- and microscopic evaluation, whether PRP accelerates the healing process as compared to a commercial ointment containing gentamicin, sulfanilamide, sulfadiazine, urea, and vitamin A (study ointment). This study used 24 white New Zealand rabbits, aged 12 months, and each weighing approximately 3 kg. The animals were separated into 4 equal groups and underwent wound induction through skin removal in the thoracic (study wound) and lumbar (control wound) dorsal midline. Study wounds were co-treated with equine PRP and the study ointment. Control wounds were treated with only the study ointment. Group I underwent histological evaluation 3 days after the skin removal procedure, group II after 7 days, group III after 14 days, and group IV after 21 days. A skin fragment was collected from each animal for histological evaluation. The co-treatment with heterologous equine PRP and the study ointment accelerated the healing process in the surgically induced skin wounds, confirming the acceleratory effect of PRP on wound healing.Keywords: healing, skin, growth factors, platelet rich plasma. |
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Co-treatment of wounds in rabbit skin with equine platelet-rich plasma and a commercial ointment accelerates healingAssociação de plasma rico em plaquetas de equino e pomada comercial no tratamento de feridas em pele de coelhoAutologous platelet-rich plasma (PRP) is beneficial in the healing process of reconstructive surgeries, contributing to the stimulation of angiogenesis; however, heterologous plasma has been shown to be more effective. The objective of this study was to verify, by macro- and microscopic evaluation, whether PRP accelerates the healing process as compared to a commercial ointment containing gentamicin, sulfanilamide, sulfadiazine, urea, and vitamin A (study ointment). This study used 24 white New Zealand rabbits, aged 12 months, and each weighing approximately 3 kg. The animals were separated into 4 equal groups and underwent wound induction through skin removal in the thoracic (study wound) and lumbar (control wound) dorsal midline. Study wounds were co-treated with equine PRP and the study ointment. Control wounds were treated with only the study ointment. Group I underwent histological evaluation 3 days after the skin removal procedure, group II after 7 days, group III after 14 days, and group IV after 21 days. A skin fragment was collected from each animal for histological evaluation. The co-treatment with heterologous equine PRP and the study ointment accelerated the healing process in the surgically induced skin wounds, confirming the acceleratory effect of PRP on wound healing.Keywords: healing, skin, growth factors, platelet rich plasma.O plasma rico em plaquetas autólogo é importante no processo cicatricial de cirurgias reconstrutivas, auxiliando na estimulação da angiogênese; no entanto, o plasma heterólogo mostrou-se mais eficaz. Utilizou-se 24 coelhos da raça Nova Zelândia, com idade de 12 meses, com peso corporal cerca de 3,0 kg. Os animais foram separados em quatro grupos de igual número e submetidos a remoção de pele na linha média dorsal torácica (ferida tratada) e lombar (ferida controle). Nas tratadas, foi aplicado plasma rico em plaqueta de equino e pomada contendo gentamicina, sulfanilamida, sulfadiazina, ureia e vitamina A e, nas do grupo controle, somente a pomada. Nos do grupo I, foi coletado tecido cutâneo para a avaliação histológica com três dias de pós-operatório, nos do grupo II com sete dias, nos do grupo III com 14 dias e, nos do grupo IV, com 21 dias. Decorrido o período de avaliação de cada grupo, foi coletado fragmento de pele para avaliação histológica. O uso associado do plasma rico em plaquetas heterólogo de equino com a pomada contendo gentamicina, sulfanilamida, sulfadiazina, ureia e vitamina A, em feridas de pele induzidas cirurgicamente acelera o processo cicatricial.Palavras-chave: cicatrização, fatores de crescimento, pele, plasma rico em plaquetasUniversidade Federal de Goiás2020-04-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlapplication/pdftext/htmlhttps://revistas.ufg.br/vet/article/view/56274Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 21 (2020): Continuous publicationCiência Animal Brasileira / Brazilian Animal Science; v. 21 (2020): Publicação contínua1809-68911518-2797reponame:Ciência animal brasileira (Online)instname:Universidade Federal de Goiás (UFG)instacron:UFGporenghttps://revistas.ufg.br/vet/article/view/56274/34665https://revistas.ufg.br/vet/article/view/56274/34666https://revistas.ufg.br/vet/article/view/56274/34667https://revistas.ufg.br/vet/article/view/56274/34668Copyright (c) 2020 Ciência Animal Brasileirainfo:eu-repo/semantics/openAccessRezende, Rodrigo Supranzetti deEurides, DuvaldoAlves, Endrigo Gabelline LeonelVenturini, Guilherme CostaFelipe, Rodrigo Lopes de2023-03-23T18:46:38Zoai:ojs.revistas.ufg.br:article/56274Revistahttps://revistas.ufg.br/vetPUBhttps://revistas.ufg.br/vet/oai||revistacab@gmail.com1809-68911518-2797opendoar:2023-03-23T18:46:38Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)false |
dc.title.none.fl_str_mv |
Co-treatment of wounds in rabbit skin with equine platelet-rich plasma and a commercial ointment accelerates healing Associação de plasma rico em plaquetas de equino e pomada comercial no tratamento de feridas em pele de coelho |
title |
Co-treatment of wounds in rabbit skin with equine platelet-rich plasma and a commercial ointment accelerates healing |
spellingShingle |
Co-treatment of wounds in rabbit skin with equine platelet-rich plasma and a commercial ointment accelerates healing Rezende, Rodrigo Supranzetti de |
title_short |
Co-treatment of wounds in rabbit skin with equine platelet-rich plasma and a commercial ointment accelerates healing |
title_full |
Co-treatment of wounds in rabbit skin with equine platelet-rich plasma and a commercial ointment accelerates healing |
title_fullStr |
Co-treatment of wounds in rabbit skin with equine platelet-rich plasma and a commercial ointment accelerates healing |
title_full_unstemmed |
Co-treatment of wounds in rabbit skin with equine platelet-rich plasma and a commercial ointment accelerates healing |
title_sort |
Co-treatment of wounds in rabbit skin with equine platelet-rich plasma and a commercial ointment accelerates healing |
author |
Rezende, Rodrigo Supranzetti de |
author_facet |
Rezende, Rodrigo Supranzetti de Eurides, Duvaldo Alves, Endrigo Gabelline Leonel Venturini, Guilherme Costa Felipe, Rodrigo Lopes de |
author_role |
author |
author2 |
Eurides, Duvaldo Alves, Endrigo Gabelline Leonel Venturini, Guilherme Costa Felipe, Rodrigo Lopes de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rezende, Rodrigo Supranzetti de Eurides, Duvaldo Alves, Endrigo Gabelline Leonel Venturini, Guilherme Costa Felipe, Rodrigo Lopes de |
description |
Autologous platelet-rich plasma (PRP) is beneficial in the healing process of reconstructive surgeries, contributing to the stimulation of angiogenesis; however, heterologous plasma has been shown to be more effective. The objective of this study was to verify, by macro- and microscopic evaluation, whether PRP accelerates the healing process as compared to a commercial ointment containing gentamicin, sulfanilamide, sulfadiazine, urea, and vitamin A (study ointment). This study used 24 white New Zealand rabbits, aged 12 months, and each weighing approximately 3 kg. The animals were separated into 4 equal groups and underwent wound induction through skin removal in the thoracic (study wound) and lumbar (control wound) dorsal midline. Study wounds were co-treated with equine PRP and the study ointment. Control wounds were treated with only the study ointment. Group I underwent histological evaluation 3 days after the skin removal procedure, group II after 7 days, group III after 14 days, and group IV after 21 days. A skin fragment was collected from each animal for histological evaluation. The co-treatment with heterologous equine PRP and the study ointment accelerated the healing process in the surgically induced skin wounds, confirming the acceleratory effect of PRP on wound healing.Keywords: healing, skin, growth factors, platelet rich plasma. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-04-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistas.ufg.br/vet/article/view/56274 |
url |
https://revistas.ufg.br/vet/article/view/56274 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://revistas.ufg.br/vet/article/view/56274/34665 https://revistas.ufg.br/vet/article/view/56274/34666 https://revistas.ufg.br/vet/article/view/56274/34667 https://revistas.ufg.br/vet/article/view/56274/34668 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Ciência Animal Brasileira info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Ciência Animal Brasileira |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/html application/pdf text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 21 (2020): Continuous publication Ciência Animal Brasileira / Brazilian Animal Science; v. 21 (2020): Publicação contínua 1809-6891 1518-2797 reponame:Ciência animal brasileira (Online) instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Ciência animal brasileira (Online) |
collection |
Ciência animal brasileira (Online) |
repository.name.fl_str_mv |
Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
||revistacab@gmail.com |
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1789440223361368064 |