SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS

Detalhes bibliográficos
Autor(a) principal: Ferreira, Felipp Silveira
Data de Publicação: 2011
Outros Autores: Silveira, Lara Lages, Costa, Alessandra Castello, Vale, Daniela Fantini, Carvalho, Claudio Baptista, Machado, Josias Alves, Oliveira, André L. de Abreu
Tipo de documento: Artigo
Idioma: por
Título da fonte: Ciência animal brasileira (Online)
Texto Completo: https://revistas.ufg.br/vet/article/view/10148
Resumo: The extracorporeal membrane oxygenation (ECMO) is a prolonged cardiopulmonary support technique, which aims to help the lungs and the heart when they do not respond to conventional non-invasive treatments. This research was carried out to determine the behavior of lactate dehydrogenase (LDH) of five mongrel dogs undergoing ECMO for three hours. Under controlled ventilation, positive end-expiratory pressure (PEEP) at 10mmHg and FiO2 at 21%, the animals were submitted to femoral cannulation for ECMO (artery and vein), by the arterial-venous (AV) deviation. The LDH was measured and evaluated every thirty minutes for an uninterrupted period of three hours. The results were tabulated and statistically analyzed with ANOVA and Tukey tests, with p<0.05. The results showed an increase of serum LDH, featuring a muscle injury during the procedure due to a physiological response, similar to that caused by a hypovolemic shock. We concluded that ECMO is a viable technique for prolonged ventilatory support, but it needs some adjustments for clinical use in dogs.KEYWORDS: dogs: ECMO; lactate dehydrogenase.
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spelling SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURSATIVIDADE DA LACTATO DESIDROGENASE (LDH) SÉRICA EM CÃES SUBMETIDOS À OXIGENAÇÃO EXTRACORPÓREA POR MEMBRANA (ECMO) POR UM PERÍODO DE TRÊS HORASAnimal sanityECMOcãeslactato desidrogenase.The extracorporeal membrane oxygenation (ECMO) is a prolonged cardiopulmonary support technique, which aims to help the lungs and the heart when they do not respond to conventional non-invasive treatments. This research was carried out to determine the behavior of lactate dehydrogenase (LDH) of five mongrel dogs undergoing ECMO for three hours. Under controlled ventilation, positive end-expiratory pressure (PEEP) at 10mmHg and FiO2 at 21%, the animals were submitted to femoral cannulation for ECMO (artery and vein), by the arterial-venous (AV) deviation. The LDH was measured and evaluated every thirty minutes for an uninterrupted period of three hours. The results were tabulated and statistically analyzed with ANOVA and Tukey tests, with p<0.05. The results showed an increase of serum LDH, featuring a muscle injury during the procedure due to a physiological response, similar to that caused by a hypovolemic shock. We concluded that ECMO is a viable technique for prolonged ventilatory support, but it needs some adjustments for clinical use in dogs.KEYWORDS: dogs: ECMO; lactate dehydrogenase.A oxigenação extracorpórea por membrana (ECMO) é uma técnica de suporte cardiopulmonar prolongado, que objetiva auxiliar os pulmões e/ou o coração quando estes não respondem aos tratamentos convencionais. Este estudo avaliou a atividade da lactato desidrogenase (LDH) sérica de cinco cães sem raça definida (SRD) submetidos à ECMO por um período de três horas. Sob pressão expiratória positiva final (PEEP) de 10mmHg, ventilação controlada e FiO2 de 21%, a ECMO foi realizada por canulação femoral (artéria e veia), em um desvio artério-venoso (AV). A atividade da LDH foi mensurada a cada trinta minutos, por três horas e os resultados analisados estatisticamente com os testes de ANOVA e Tukey, com atividade da LDH, caracterizando uma lesão muscular ao longo do procedimento, em virtude de uma resposta fisiológica semelhante àquela causada por um choque hipovolêmico. Conclui-se que a ECMO é uma técnica viável de suporte, mas necessita de adaptações para uso clínico em cães.PALAVRAS-CHAVE: cães; ECMO; lactato desidrogenase.Universidade Federal de Goiás2011-09-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionResearchAvaliado por paresPesquisa científicaapplication/pdftext/htmlhttps://revistas.ufg.br/vet/article/view/1014810.5216/cab.v12i3.10148Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 12 No. 3 (2011); 554-559Ciência Animal Brasileira / Brazilian Animal Science; v. 12 n. 3 (2011); 554-5591809-68911518-2797reponame:Ciência animal brasileira (Online)instname:Universidade Federal de Goiás (UFG)instacron:UFGporhttps://revistas.ufg.br/vet/article/view/10148/9716https://revistas.ufg.br/vet/article/view/10148/9717Ferreira, Felipp SilveiraSilveira, Lara LagesCosta, Alessandra CastelloVale, Daniela FantiniCarvalho, Claudio BaptistaMachado, Josias AlvesOliveira, André L. de Abreuinfo:eu-repo/semantics/openAccess2012-07-01T14:38:07Zoai:ojs.revistas.ufg.br:article/10148Revistahttps://revistas.ufg.br/vetPUBhttps://revistas.ufg.br/vet/oai||revistacab@gmail.com1809-68911518-2797opendoar:2024-05-21T19:55:44.491899Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)true
dc.title.none.fl_str_mv SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS
ATIVIDADE DA LACTATO DESIDROGENASE (LDH) SÉRICA EM CÃES SUBMETIDOS À OXIGENAÇÃO EXTRACORPÓREA POR MEMBRANA (ECMO) POR UM PERÍODO DE TRÊS HORAS
title SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS
spellingShingle SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS
Ferreira, Felipp Silveira
Animal sanity
ECMO
cães
lactato desidrogenase.
title_short SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS
title_full SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS
title_fullStr SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS
title_full_unstemmed SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS
title_sort SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS
author Ferreira, Felipp Silveira
author_facet Ferreira, Felipp Silveira
Silveira, Lara Lages
Costa, Alessandra Castello
Vale, Daniela Fantini
Carvalho, Claudio Baptista
Machado, Josias Alves
Oliveira, André L. de Abreu
author_role author
author2 Silveira, Lara Lages
Costa, Alessandra Castello
Vale, Daniela Fantini
Carvalho, Claudio Baptista
Machado, Josias Alves
Oliveira, André L. de Abreu
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Felipp Silveira
Silveira, Lara Lages
Costa, Alessandra Castello
Vale, Daniela Fantini
Carvalho, Claudio Baptista
Machado, Josias Alves
Oliveira, André L. de Abreu
dc.subject.por.fl_str_mv Animal sanity
ECMO
cães
lactato desidrogenase.
topic Animal sanity
ECMO
cães
lactato desidrogenase.
description The extracorporeal membrane oxygenation (ECMO) is a prolonged cardiopulmonary support technique, which aims to help the lungs and the heart when they do not respond to conventional non-invasive treatments. This research was carried out to determine the behavior of lactate dehydrogenase (LDH) of five mongrel dogs undergoing ECMO for three hours. Under controlled ventilation, positive end-expiratory pressure (PEEP) at 10mmHg and FiO2 at 21%, the animals were submitted to femoral cannulation for ECMO (artery and vein), by the arterial-venous (AV) deviation. The LDH was measured and evaluated every thirty minutes for an uninterrupted period of three hours. The results were tabulated and statistically analyzed with ANOVA and Tukey tests, with p<0.05. The results showed an increase of serum LDH, featuring a muscle injury during the procedure due to a physiological response, similar to that caused by a hypovolemic shock. We concluded that ECMO is a viable technique for prolonged ventilatory support, but it needs some adjustments for clinical use in dogs.KEYWORDS: dogs: ECMO; lactate dehydrogenase.
publishDate 2011
dc.date.none.fl_str_mv 2011-09-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Research
Avaliado por pares
Pesquisa científica
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistas.ufg.br/vet/article/view/10148
10.5216/cab.v12i3.10148
url https://revistas.ufg.br/vet/article/view/10148
identifier_str_mv 10.5216/cab.v12i3.10148
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistas.ufg.br/vet/article/view/10148/9716
https://revistas.ufg.br/vet/article/view/10148/9717
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Universidade Federal de Goiás
publisher.none.fl_str_mv Universidade Federal de Goiás
dc.source.none.fl_str_mv Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 12 No. 3 (2011); 554-559
Ciência Animal Brasileira / Brazilian Animal Science; v. 12 n. 3 (2011); 554-559
1809-6891
1518-2797
reponame:Ciência animal brasileira (Online)
instname:Universidade Federal de Goiás (UFG)
instacron:UFG
instname_str Universidade Federal de Goiás (UFG)
instacron_str UFG
institution UFG
reponame_str Ciência animal brasileira (Online)
collection Ciência animal brasileira (Online)
repository.name.fl_str_mv Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)
repository.mail.fl_str_mv ||revistacab@gmail.com
_version_ 1799874787031384064

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