NEPHROTOXICITY OF PREDNISONE IN CATS
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Ciência animal brasileira (Online) |
Texto Completo: | https://revistas.ufg.br/vet/article/view/4890 |
Resumo: | The nefrotoxicity of prednisone in cats was evaluated, using an immunesupressor dose (5 mg/kg/day), by establishing blood count, serum biochemistry (urea and creatinine) and urinary (GGT, protein and creatinine) parameters and urinalysis. Eight cats were used. The animals were of undefinied breed, adults and with average weight of 3 kg. They were housed in four cubicles and fed with two measures of commercial ration per day and water ad libitum during an adaptation period of seven days. The trial design was entirely random, being rejected any specific criterion of inclusion in this study besides the absence of any previous kidney damage. Animals received 5 mg / kg prednisone, orally, every 24 hours for a period of 14 days. The samples were collected in two different times, with the animals resting before prednisone administration (M1), and 14 days after the administration (M2). Significant differences were found in some hematological and biochemical parameters as well as in urinalysis. It was concluded that the prednisone (5 mg / kg / day), during a period of 14 days, is potentially nephrotoxic and the determination of the urinary GGT activity was proven to be precisely sensitive to early proximal tubular injury.KEYWORDS: corticoid; feline; GGT; nephrotoxicity. |
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NEPHROTOXICITY OF PREDNISONE IN CATSDeterminación de conteo sanguíneo, parámetros de bioquímicos séricos (urea y creatinina) y urinarios (GGT, proteína y creatinina) y análisis de orina en gatos presentado a corticoterapyNEFROTOXICIDADE DA PREDNISONA EM FELINOSAnimal SanityFelinosGGTcorticóidenefrotoxicidade.The nefrotoxicity of prednisone in cats was evaluated, using an immunesupressor dose (5 mg/kg/day), by establishing blood count, serum biochemistry (urea and creatinine) and urinary (GGT, protein and creatinine) parameters and urinalysis. Eight cats were used. The animals were of undefinied breed, adults and with average weight of 3 kg. They were housed in four cubicles and fed with two measures of commercial ration per day and water ad libitum during an adaptation period of seven days. The trial design was entirely random, being rejected any specific criterion of inclusion in this study besides the absence of any previous kidney damage. Animals received 5 mg / kg prednisone, orally, every 24 hours for a period of 14 days. The samples were collected in two different times, with the animals resting before prednisone administration (M1), and 14 days after the administration (M2). Significant differences were found in some hematological and biochemical parameters as well as in urinalysis. It was concluded that the prednisone (5 mg / kg / day), during a period of 14 days, is potentially nephrotoxic and the determination of the urinary GGT activity was proven to be precisely sensitive to early proximal tubular injury.KEYWORDS: corticoid; feline; GGT; nephrotoxicity.Avaliou-se a nefrotoxicidade da prednisona em felinos com utilização de dose imunossupressora (5mg/kg/dia), por meio do hemograma, dos parâmetros bioquímicos séricos (uréia e creatinina) e urinários (GGT, proteína e creatinina) e da urinálise. Foram utilizados oito gatos, sem raça definida (SRD), adultos e com peso médio de 3 Kg. Os animais foram alojados em quatro baias (dois animais por baia) e alimentados com duas medidas de ração comercial por dia e água ad libitum por um período de adaptação de sete dias. O delineamento experimental foi inteiramente casualizado, sendo rejeitado qualquer critério específico de inclusão no trabalho, além da ausência de qualquer lesão renal prévia. Os animais receberam 5mg/kg de prednisona via oral a cada 24 horas por um período de 14 dias. As amostras foram coletadas em dois momentos, sendo animais em repouso antes da administração de prednisona (M1) e 14 dias (M2) após o início da administração do fármaco. Foram observadas diferenças significativas em alguns parâmetros hematológicos, bioquímicos e na urinálise. Conclui-se que a prednisona na dose imunossupressora (5mg/kg/dia) durante um período de 14 dias é potencialmente nefrotóxica e que a determinação da atividade da GGT urinária mostrou-se precisamente sensível à lesão tubular proximal precoce.PALAVRAS-CHAVE: corticoide; felinos; GGT; nefrotoxicidade.Universidade Federal de Goiás2012-09-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionResearchAvaliado por paresPesquisa Científicaapplication/pdftext/htmlapplication/pdfhttps://revistas.ufg.br/vet/article/view/489010.5216/cab.v13i3.4890Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 13 No. 3 (2012); 353-358Ciência Animal Brasileira / Brazilian Animal Science; v. 13 n. 3 (2012); 353-3581809-68911518-2797reponame:Ciência animal brasileira (Online)instname:Universidade Federal de Goiás (UFG)instacron:UFGporhttps://revistas.ufg.br/vet/article/view/4890/11967https://revistas.ufg.br/vet/article/view/4890/11968https://revistas.ufg.br/vet/article/view/4890/15430Fonseca, Leandro AbreuTon, AngeloCosta, Fabiano SellosAlves, AndréaGalaes, GeórgiaGirardi, Fabrícia Modoloinfo:eu-repo/semantics/openAccess2012-09-29T02:15:59Zoai:ojs.revistas.ufg.br:article/4890Revistahttps://revistas.ufg.br/vetPUBhttps://revistas.ufg.br/vet/oai||revistacab@gmail.com1809-68911518-2797opendoar:2024-05-21T19:55:18.280336Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)true |
dc.title.none.fl_str_mv |
NEPHROTOXICITY OF PREDNISONE IN CATS Determinación de conteo sanguíneo, parámetros de bioquímicos séricos (urea y creatinina) y urinarios (GGT, proteína y creatinina) y análisis de orina en gatos presentado a corticoterapy NEFROTOXICIDADE DA PREDNISONA EM FELINOS |
title |
NEPHROTOXICITY OF PREDNISONE IN CATS |
spellingShingle |
NEPHROTOXICITY OF PREDNISONE IN CATS Fonseca, Leandro Abreu Animal Sanity Felinos GGT corticóide nefrotoxicidade. |
title_short |
NEPHROTOXICITY OF PREDNISONE IN CATS |
title_full |
NEPHROTOXICITY OF PREDNISONE IN CATS |
title_fullStr |
NEPHROTOXICITY OF PREDNISONE IN CATS |
title_full_unstemmed |
NEPHROTOXICITY OF PREDNISONE IN CATS |
title_sort |
NEPHROTOXICITY OF PREDNISONE IN CATS |
author |
Fonseca, Leandro Abreu |
author_facet |
Fonseca, Leandro Abreu Ton, Angelo Costa, Fabiano Sellos Alves, Andréa Galaes, Geórgia Girardi, Fabrícia Modolo |
author_role |
author |
author2 |
Ton, Angelo Costa, Fabiano Sellos Alves, Andréa Galaes, Geórgia Girardi, Fabrícia Modolo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Fonseca, Leandro Abreu Ton, Angelo Costa, Fabiano Sellos Alves, Andréa Galaes, Geórgia Girardi, Fabrícia Modolo |
dc.subject.por.fl_str_mv |
Animal Sanity Felinos GGT corticóide nefrotoxicidade. |
topic |
Animal Sanity Felinos GGT corticóide nefrotoxicidade. |
description |
The nefrotoxicity of prednisone in cats was evaluated, using an immunesupressor dose (5 mg/kg/day), by establishing blood count, serum biochemistry (urea and creatinine) and urinary (GGT, protein and creatinine) parameters and urinalysis. Eight cats were used. The animals were of undefinied breed, adults and with average weight of 3 kg. They were housed in four cubicles and fed with two measures of commercial ration per day and water ad libitum during an adaptation period of seven days. The trial design was entirely random, being rejected any specific criterion of inclusion in this study besides the absence of any previous kidney damage. Animals received 5 mg / kg prednisone, orally, every 24 hours for a period of 14 days. The samples were collected in two different times, with the animals resting before prednisone administration (M1), and 14 days after the administration (M2). Significant differences were found in some hematological and biochemical parameters as well as in urinalysis. It was concluded that the prednisone (5 mg / kg / day), during a period of 14 days, is potentially nephrotoxic and the determination of the urinary GGT activity was proven to be precisely sensitive to early proximal tubular injury.KEYWORDS: corticoid; feline; GGT; nephrotoxicity. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-09-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Research Avaliado por pares Pesquisa Científica |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistas.ufg.br/vet/article/view/4890 10.5216/cab.v13i3.4890 |
url |
https://revistas.ufg.br/vet/article/view/4890 |
identifier_str_mv |
10.5216/cab.v13i3.4890 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revistas.ufg.br/vet/article/view/4890/11967 https://revistas.ufg.br/vet/article/view/4890/11968 https://revistas.ufg.br/vet/article/view/4890/15430 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/html application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 13 No. 3 (2012); 353-358 Ciência Animal Brasileira / Brazilian Animal Science; v. 13 n. 3 (2012); 353-358 1809-6891 1518-2797 reponame:Ciência animal brasileira (Online) instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Ciência animal brasileira (Online) |
collection |
Ciência animal brasileira (Online) |
repository.name.fl_str_mv |
Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
||revistacab@gmail.com |
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1799874785128218624 |