Vírus Epstein-Barr associado ao Linfoma de Hodgkin clássico: um estudo de casos

• Autor(a) principal: Toledo Costa Mayrink , Graziela
• Data de Publicação: 2024
• Outros Autores: Borges dos Santos, Kelli, Diniz Ferreira, Julia, Hallack Neto, Abrahão Elias
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: HU Revista (Online)
• Texto Completo: https://periodicos.ufjf.br/index.php/hurevista/article/view/43242
• topic: Epstein-Barr virus; Hodgkin’s Lymphoma; Prognosis; Doença de Hodgkin; Infecções por Vírus Epstein-Barr; Prognóstico

Introduction: The expression of EBV (Epstein-Barr virus) presence in Hodgkin/Reed-Sternberg cells and its association with the prognosis remains controversial. Objectives: The present study aims to identify the occurrence of EBV in patients with Hodgkin's lymphoma and to associate the clinical outcome with positivity in patients.  Methods:  To determine the presence of EBV, a paraffin-embedded tissue biopsy was performed and analysed through hybridization for EBV-encoded RNA and immunohistochemistry for viral latent membrane protein (LMP-1). The procedure was conducted by a hematopathologist blinded to the outcome of EBV status in cHL tumour cells. Prognostic factors of the International Prognosis Score for advanced stage and risk factors of the German Hodgkin Study Group for limited stage were correlated with EBV status. Results: Slides of biopsy were retrieved from 29 patients diagnosed with Hodgkin's Lymphoma. The mixed cellularity histological subtype showed statistic association with EBV-positive status (p= 0.02). In addition, EBV-positive cHL status was more common in patients aged 45 years or older (p= 0.07). There was a trend suggesting improved event-free survival (p=0.07), but it did not reach levels of statistical significance. Conclusion: Although it is related to mixed cellularity histological subtype, the prognosis association of cHL and EBV-status tumour cells has not been clearly established in the present study.