Métodos de preparação e atividade biológica do ácido quinolínico e derivados
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2003 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da UFJF |
| Texto Completo: | http://dx.doi.org/10.1590/S0100-40422003000500013 https://repositorio.ufjf.br/jspui/handle/ufjf/9116 |
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2019-02-22T12:19:06Z2019-02-192019-02-22T12:19:06Z2003-10265694698http://dx.doi.org/10.1590/S0100-40422003000500013https://repositorio.ufjf.br/jspui/handle/ufjf/9116-In 1981 2,3-pyridine dicarboxylic acid (quinolinic acid) was discovery to be a selective agonist for the N-methyl -D-aspartic acid (NMDA) receptor. As a consequence it possesses neurotoxic activity resulting from overstimulation of the receptor. Quinolinic acid is implicated as an etiological factor in a range of neurodegenerative disease including AIDS related dementia, Huntington´s disease and Lyme disease. In the design of novel therapies to treat these diseases, some molecules have been identified as an important target. In this paper we described different methods to prepare quinolinic acid and derivatives.por--BrasilQuímica Nova-Quinolinic acidNMDA receptorAIDS related dementiaMétodos de preparação e atividade biológica do ácido quinolínico e derivadosMethods of preparation and biological activity of quinolinic acid and derivativesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSouza, Marcus Vinícius Nora deAlmeida, Mauro Vieira deHyaric, Mireille LeCardoso, Sílvia HelenaAmarante, Giovanni Wilsoninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILMétodos de preparação e atividade biológica do ácido quinolínico e derivados.pdf.jpgMétodos de preparação e atividade biológica do ácido quinolínico e derivados.pdf.jpgGenerated Thumbnailimage/jpeg1619https://repositorio.ufjf.br/jspui/bitstream/ufjf/9116/4/M%c3%a9todos%20de%20prepara%c3%a7%c3%a3o%20e%20atividade%20biol%c3%b3gica%20do%20%c3%a1cido%20quinol%c3%adnico%20e%20derivados.pdf.jpg4847f7ce5baef171971e44ad5303fe3aMD54ORIGINALMétodos de preparação e atividade biológica do ácido quinolínico e derivados.pdfMétodos de preparação e atividade biológica do ácido quinolínico e derivados.pdfapplication/pdf477546https://repositorio.ufjf.br/jspui/bitstream/ufjf/9116/1/M%c3%a9todos%20de%20prepara%c3%a7%c3%a3o%20e%20atividade%20biol%c3%b3gica%20do%20%c3%a1cido%20quinol%c3%adnico%20e%20derivados.pdf3fc3735144cc70b382f2254678295a1eMD51LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Métodos de preparação e atividade biológica do ácido quinolínico e derivados |
| dc.title.alternative.pt_BR.fl_str_mv |
Methods of preparation and biological activity of quinolinic acid and derivatives |
| title |
Métodos de preparação e atividade biológica do ácido quinolínico e derivados |
| spellingShingle |
Métodos de preparação e atividade biológica do ácido quinolínico e derivados Souza, Marcus Vinícius Nora de - Quinolinic acid NMDA receptor AIDS related dementia |
| title_short |
Métodos de preparação e atividade biológica do ácido quinolínico e derivados |
| title_full |
Métodos de preparação e atividade biológica do ácido quinolínico e derivados |
| title_fullStr |
Métodos de preparação e atividade biológica do ácido quinolínico e derivados |
| title_full_unstemmed |
Métodos de preparação e atividade biológica do ácido quinolínico e derivados |
| title_sort |
Métodos de preparação e atividade biológica do ácido quinolínico e derivados |
| author |
Souza, Marcus Vinícius Nora de |
| author_facet |
Souza, Marcus Vinícius Nora de Almeida, Mauro Vieira de Hyaric, Mireille Le Cardoso, Sílvia Helena Amarante, Giovanni Wilson |
| author_role |
author |
| author2 |
Almeida, Mauro Vieira de Hyaric, Mireille Le Cardoso, Sílvia Helena Amarante, Giovanni Wilson |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Marcus Vinícius Nora de Almeida, Mauro Vieira de Hyaric, Mireille Le Cardoso, Sílvia Helena Amarante, Giovanni Wilson |
| dc.subject.cnpq.fl_str_mv |
- |
| topic |
- Quinolinic acid NMDA receptor AIDS related dementia |
| dc.subject.por.fl_str_mv |
Quinolinic acid NMDA receptor AIDS related dementia |
| description |
- |
| publishDate |
2003 |
| dc.date.issued.fl_str_mv |
2003-10 |
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2019-02-22T12:19:06Z |
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2019-02-19 2019-02-22T12:19:06Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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https://repositorio.ufjf.br/jspui/handle/ufjf/9116 |
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http://dx.doi.org/10.1590/S0100-40422003000500013 |
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http://dx.doi.org/10.1590/S0100-40422003000500013 https://repositorio.ufjf.br/jspui/handle/ufjf/9116 |
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por |
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por |
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Química Nova |
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info:eu-repo/semantics/openAccess |
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openAccess |
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- |
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- |
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Brasil |
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