Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi

Detalhes bibliográficos
Autor(a) principal: Paiva,Rojane de Oliveira
Data de Publicação: 2014
Outros Autores: Kneipp,Lucimar Ferreira, Goular,Carla Marins, Albuquerque,Mariana Almeida, Echevarria,Aurea
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência e Agrotecnologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542014000600001
Resumo: Mycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A. ochraceus, A. parasiticus and Fusarium verticillioides. Thiosemicarbazones had MIC values of 125-500 µg/ml. The thiosemicarbazones 1 and 2 exerted fungistatic activity against Aspergillus spp., and thiosemicarbazone 2 exerted fungicidal activity against F. verticillioides. Compound 2 showed an iron chelating effect of 63%. The ergosterol content of A. parasiticus had a decrease of 28 and 71% for the 31.2 and 62.5 µg/ml concentrations of thiosemicarbazone 2 compared to the control. The obtained results of antifungal activity revealed that thiosemicarbazone class was more active when compared to semicarbazone class and, the thiosemicarbazone 2 was the most active compound, specially, against Aspergillus spp.
id UFLA-2_a79d4534e257702aea56c6290ec1717e
oai_identifier_str oai:scielo:S1413-70542014000600001
network_acronym_str UFLA-2
network_name_str Ciência e Agrotecnologia (Online)
repository_id_str
spelling Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungiAspergillusFusariummycotoxicologythiosemicarbazonesMycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A. ochraceus, A. parasiticus and Fusarium verticillioides. Thiosemicarbazones had MIC values of 125-500 µg/ml. The thiosemicarbazones 1 and 2 exerted fungistatic activity against Aspergillus spp., and thiosemicarbazone 2 exerted fungicidal activity against F. verticillioides. Compound 2 showed an iron chelating effect of 63%. The ergosterol content of A. parasiticus had a decrease of 28 and 71% for the 31.2 and 62.5 µg/ml concentrations of thiosemicarbazone 2 compared to the control. The obtained results of antifungal activity revealed that thiosemicarbazone class was more active when compared to semicarbazone class and, the thiosemicarbazone 2 was the most active compound, specially, against Aspergillus spp.Editora da UFLA2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542014000600001Ciência e Agrotecnologia v.38 n.6 2014reponame:Ciência e Agrotecnologia (Online)instname:Universidade Federal de Lavras (UFLA)instacron:UFLA10.1590/S1413-70542014000600001info:eu-repo/semantics/openAccessPaiva,Rojane de OliveiraKneipp,Lucimar FerreiraGoular,Carla MarinsAlbuquerque,Mariana AlmeidaEchevarria,Aureaeng2014-11-03T00:00:00Zoai:scielo:S1413-70542014000600001Revistahttp://www.scielo.br/cagroPUBhttps://old.scielo.br/oai/scielo-oai.php||renpaiva@dbi.ufla.br|| editora@editora.ufla.br1981-18291413-7054opendoar:2014-11-03T00:00Ciência e Agrotecnologia (Online) - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi
title Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi
spellingShingle Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi
Paiva,Rojane de Oliveira
Aspergillus
Fusarium
mycotoxicology
thiosemicarbazones
title_short Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi
title_full Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi
title_fullStr Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi
title_full_unstemmed Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi
title_sort Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi
author Paiva,Rojane de Oliveira
author_facet Paiva,Rojane de Oliveira
Kneipp,Lucimar Ferreira
Goular,Carla Marins
Albuquerque,Mariana Almeida
Echevarria,Aurea
author_role author
author2 Kneipp,Lucimar Ferreira
Goular,Carla Marins
Albuquerque,Mariana Almeida
Echevarria,Aurea
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Paiva,Rojane de Oliveira
Kneipp,Lucimar Ferreira
Goular,Carla Marins
Albuquerque,Mariana Almeida
Echevarria,Aurea
dc.subject.por.fl_str_mv Aspergillus
Fusarium
mycotoxicology
thiosemicarbazones
topic Aspergillus
Fusarium
mycotoxicology
thiosemicarbazones
description Mycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A. ochraceus, A. parasiticus and Fusarium verticillioides. Thiosemicarbazones had MIC values of 125-500 µg/ml. The thiosemicarbazones 1 and 2 exerted fungistatic activity against Aspergillus spp., and thiosemicarbazone 2 exerted fungicidal activity against F. verticillioides. Compound 2 showed an iron chelating effect of 63%. The ergosterol content of A. parasiticus had a decrease of 28 and 71% for the 31.2 and 62.5 µg/ml concentrations of thiosemicarbazone 2 compared to the control. The obtained results of antifungal activity revealed that thiosemicarbazone class was more active when compared to semicarbazone class and, the thiosemicarbazone 2 was the most active compound, specially, against Aspergillus spp.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542014000600001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542014000600001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-70542014000600001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Editora da UFLA
publisher.none.fl_str_mv Editora da UFLA
dc.source.none.fl_str_mv Ciência e Agrotecnologia v.38 n.6 2014
reponame:Ciência e Agrotecnologia (Online)
instname:Universidade Federal de Lavras (UFLA)
instacron:UFLA
instname_str Universidade Federal de Lavras (UFLA)
instacron_str UFLA
institution UFLA
reponame_str Ciência e Agrotecnologia (Online)
collection Ciência e Agrotecnologia (Online)
repository.name.fl_str_mv Ciência e Agrotecnologia (Online) - Universidade Federal de Lavras (UFLA)
repository.mail.fl_str_mv ||renpaiva@dbi.ufla.br|| editora@editora.ufla.br
_version_ 1750226494867636224

Registros relacionados