Weight loss during cirrhosis is related to the etiology of liver disease

Detalhes bibliográficos
Autor(a) principal: Anastácio, Lucilene Rezende
Data de Publicação: 2012
Outros Autores: Ferreira, Lívia Garcia, Ribeiro, Hélem de Sena, Lima, Agnaldo Soares, Vilela, Eduardo Garcia, Correia, Maria Isabel Toulson Davisson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFLA
Texto Completo: http://repositorio.ufla.br/jspui/handle/1/38770
Resumo: CONTEXT: Malnutrition is widely described in patients waiting for liver transplantation (LTx). However, risk factors associated with weight loss during liver disease have not yet been well studied. OBJECTIVES: The aim of this study was to assess weight loss and its risk factors during liver disease and up to the first appointment after transplantation. Patients who underwent LTx were retrospectively assessed for weight loss during liver disease while on the waiting list for LTx. The usual weight of the patients before disease and their weight on the first outpatient appointment after transplant were considered. Demographic, socioeconomic, lifestyle and clinical variables were collected to assess risk factors using a linear regression analysis. We retrospectively evaluated 163 patients undergoing LTx between 1997 and 2008. RESULTS: Patients lost in average 7.7 ± 12.4 kg while ill. Variables independently associated with weight loss by multiple linear regression analyses were as follows: former smoker (P = 0.03), greater body mass index (P<0.01), overweight before liver disease (P = 0.02) and indication for LTx (P = 0.01). Among these indications, patients with alcoholic cirrhosis had lost significantly more weight (P<0.01), and those with hepatitis C virus (P = 0.01) and autoimmune hepatitis (P = 0.02) had lost significantly less weight. CONCLUSIONS: Patients experienced weight loss during liver disease independent of age, sex, schooling and income; however, the etiology of liver disease was related to weight loss.
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spelling Weight loss during cirrhosis is related to the etiology of liver diseasePerda de peso durante a cirrose está relacionada à causa da doença hepáticaWeight lossLiver cirrhosisAlcoholicLiver diseasesLiver transplantationPerda de pesoCirrose hepática alcoólicaHepatopatiasTransplante de fígadoCONTEXT: Malnutrition is widely described in patients waiting for liver transplantation (LTx). However, risk factors associated with weight loss during liver disease have not yet been well studied. OBJECTIVES: The aim of this study was to assess weight loss and its risk factors during liver disease and up to the first appointment after transplantation. Patients who underwent LTx were retrospectively assessed for weight loss during liver disease while on the waiting list for LTx. The usual weight of the patients before disease and their weight on the first outpatient appointment after transplant were considered. Demographic, socioeconomic, lifestyle and clinical variables were collected to assess risk factors using a linear regression analysis. We retrospectively evaluated 163 patients undergoing LTx between 1997 and 2008. RESULTS: Patients lost in average 7.7 ± 12.4 kg while ill. Variables independently associated with weight loss by multiple linear regression analyses were as follows: former smoker (P = 0.03), greater body mass index (P<0.01), overweight before liver disease (P = 0.02) and indication for LTx (P = 0.01). Among these indications, patients with alcoholic cirrhosis had lost significantly more weight (P<0.01), and those with hepatitis C virus (P = 0.01) and autoimmune hepatitis (P = 0.02) had lost significantly less weight. CONCLUSIONS: Patients experienced weight loss during liver disease independent of age, sex, schooling and income; however, the etiology of liver disease was related to weight loss.CONTEXTO: A desnutrição é amplamente descrita em pacientes à espera de transplante hepático (LTx). No entanto, fatores de risco associados à perda de peso durante a doença do fígado ainda não foram bem estudados. OBJETIVOS: Avaliar a perda de peso e seus fatores de risco durante a doença do fígado e até a primeira consulta após o transplante. Pacientes submetidos ao LTx foram retrospectivamente avaliados para perda de peso durante a doença do fígado, enquanto na lista de espera para LTx. O peso usual dos pacientes antes da doença e seu primeiro peso ambulatorial após o transplante foram considerados para as análises. Variáveis demográficas, de estilo de vida, socioeconômicas e variáveis clínicas foram coletadas para avaliar fatores de risco, usando análise de regressão linear múltipla. RESULTADOS: Foram avaliados retrospectivamente 163 pacientes submetidos a LTx entre 1997 e 2008. Os pacientes perderam em média 7,7 ± 12,4 kg, quando doentes. Variáveis independentemente associadas à perda de peso foram as seguintes: ex-fumante (P = 0,03), maior índice de massa corporal (P<0,01), excesso de peso antes de doença hepática (P = 0,02), indicação ao transplante (P = 0,01). Das indicações ao transplante, os indivíduos que foram diagnosticados com cirrose etanólica perderam significantemente mais peso (P<0,01) e os diagnosticados com hepatite viral C (P = 0,01) e hepatite autoimune (P = 0,02), significantemente menos. CONCLUSÕES: Os pacientes estudados apresentaram perda de peso durante a doença do fígado independentemente da idade, sexo, escolaridade e renda, no entanto, a causa da doença hepática esteve relacionada à perda de peso.Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades (IBEPEGE)2020-01-30T18:31:32Z2020-01-30T18:31:32Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfANASTÁCIO, L. R. et al. Weight loss during cirrhosis is related to the etiology of liver disease. Arquivos de Gastroenterologia, São Paulo, v. 49, n. 3, July/Sept. 2012.http://repositorio.ufla.br/jspui/handle/1/38770Arquivos de Gastroenterologiareponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessAnastácio, Lucilene RezendeFerreira, Lívia GarciaRibeiro, Hélem de SenaLima, Agnaldo SoaresVilela, Eduardo GarciaCorreia, Maria Isabel Toulson Davissoneng2020-01-30T18:31:32Zoai:localhost:1/38770Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2020-01-30T18:31:32Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv Weight loss during cirrhosis is related to the etiology of liver disease
Perda de peso durante a cirrose está relacionada à causa da doença hepática
title Weight loss during cirrhosis is related to the etiology of liver disease
spellingShingle Weight loss during cirrhosis is related to the etiology of liver disease
Anastácio, Lucilene Rezende
Weight loss
Liver cirrhosis
Alcoholic
Liver diseases
Liver transplantation
Perda de peso
Cirrose hepática alcoólica
Hepatopatias
Transplante de fígado
title_short Weight loss during cirrhosis is related to the etiology of liver disease
title_full Weight loss during cirrhosis is related to the etiology of liver disease
title_fullStr Weight loss during cirrhosis is related to the etiology of liver disease
title_full_unstemmed Weight loss during cirrhosis is related to the etiology of liver disease
title_sort Weight loss during cirrhosis is related to the etiology of liver disease
author Anastácio, Lucilene Rezende
author_facet Anastácio, Lucilene Rezende
Ferreira, Lívia Garcia
Ribeiro, Hélem de Sena
Lima, Agnaldo Soares
Vilela, Eduardo Garcia
Correia, Maria Isabel Toulson Davisson
author_role author
author2 Ferreira, Lívia Garcia
Ribeiro, Hélem de Sena
Lima, Agnaldo Soares
Vilela, Eduardo Garcia
Correia, Maria Isabel Toulson Davisson
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Anastácio, Lucilene Rezende
Ferreira, Lívia Garcia
Ribeiro, Hélem de Sena
Lima, Agnaldo Soares
Vilela, Eduardo Garcia
Correia, Maria Isabel Toulson Davisson
dc.subject.por.fl_str_mv Weight loss
Liver cirrhosis
Alcoholic
Liver diseases
Liver transplantation
Perda de peso
Cirrose hepática alcoólica
Hepatopatias
Transplante de fígado
topic Weight loss
Liver cirrhosis
Alcoholic
Liver diseases
Liver transplantation
Perda de peso
Cirrose hepática alcoólica
Hepatopatias
Transplante de fígado
description CONTEXT: Malnutrition is widely described in patients waiting for liver transplantation (LTx). However, risk factors associated with weight loss during liver disease have not yet been well studied. OBJECTIVES: The aim of this study was to assess weight loss and its risk factors during liver disease and up to the first appointment after transplantation. Patients who underwent LTx were retrospectively assessed for weight loss during liver disease while on the waiting list for LTx. The usual weight of the patients before disease and their weight on the first outpatient appointment after transplant were considered. Demographic, socioeconomic, lifestyle and clinical variables were collected to assess risk factors using a linear regression analysis. We retrospectively evaluated 163 patients undergoing LTx between 1997 and 2008. RESULTS: Patients lost in average 7.7 ± 12.4 kg while ill. Variables independently associated with weight loss by multiple linear regression analyses were as follows: former smoker (P = 0.03), greater body mass index (P<0.01), overweight before liver disease (P = 0.02) and indication for LTx (P = 0.01). Among these indications, patients with alcoholic cirrhosis had lost significantly more weight (P<0.01), and those with hepatitis C virus (P = 0.01) and autoimmune hepatitis (P = 0.02) had lost significantly less weight. CONCLUSIONS: Patients experienced weight loss during liver disease independent of age, sex, schooling and income; however, the etiology of liver disease was related to weight loss.
publishDate 2012
dc.date.none.fl_str_mv 2012
2020-01-30T18:31:32Z
2020-01-30T18:31:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv ANASTÁCIO, L. R. et al. Weight loss during cirrhosis is related to the etiology of liver disease. Arquivos de Gastroenterologia, São Paulo, v. 49, n. 3, July/Sept. 2012.
http://repositorio.ufla.br/jspui/handle/1/38770
identifier_str_mv ANASTÁCIO, L. R. et al. Weight loss during cirrhosis is related to the etiology of liver disease. Arquivos de Gastroenterologia, São Paulo, v. 49, n. 3, July/Sept. 2012.
url http://repositorio.ufla.br/jspui/handle/1/38770
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades (IBEPEGE)
publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia e Outras Especialidades (IBEPEGE)
dc.source.none.fl_str_mv Arquivos de Gastroenterologia
reponame:Repositório Institucional da UFLA
instname:Universidade Federal de Lavras (UFLA)
instacron:UFLA
instname_str Universidade Federal de Lavras (UFLA)
instacron_str UFLA
institution UFLA
reponame_str Repositório Institucional da UFLA
collection Repositório Institucional da UFLA
repository.name.fl_str_mv Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)
repository.mail.fl_str_mv nivaldo@ufla.br || repositorio.biblioteca@ufla.br
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