Tubulopapillary rectal adenocarcinoma in dog: clinical, surgical, pathological and immunophenotypical aspects: case report

• Main Author: Oliveira,A.R.
• Publication Date: 2018
• Other Authors: Flecher,M.C., Horta,R.S., Souza,M.C.C., Hardt,I., Gonçalves,A.B.B., Cassali,G.D., Souza,T.D.
• Format: Article
• Language: eng
• Source: Arquivo brasileiro de medicina veterinária e zootecnia (Online)
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000200463
• topic: enteric neoplasm; COX-2; oncology; carcinomatosis; metastasis

ABSTRACT Intestinal carcinomas are rare in dogs. The prognosis and survival time are dependent of the histological type, the invasion of the intestinal wall by the malignant cells and the ability of primary neoplasm to produce metastasis. This study reports a case of a Yorkshire dog that developed a rectal tubulopapillary adenocarcinoma progressing to a peritoneal carcinomatosis and multiple metastasis in large intestines, bladder, kidney, iliac lymph node, liver and lungs, six months after transanal surgical resection of the primary rectal neoplasm. Clinical, surgical, pathological and immunophenotypic findings are described. COX-2 imunohistochemical score was higher in hepatic metastasis (score 9) than in the primary tumour (score 6), and the growth fraction (Ki-67) observed was of 49.2% in the rectal neoplasm.