Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits

Bibliographic Details
Main Author: Souza,A.H.
Publication Date: 2008
Other Authors: Valadão,C.A.A., Selegatto,M.A., Almeida,R.M., Macari,M.
Format: Article
Language: eng
Source: Arquivo brasileiro de medicina veterinária e zootecnia (Online)
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016
Summary: The present study was designed to determine whether DMSO causes an inhibition on the development of fever in rabbits. The intravenous administration of LPS (1.5µg.kg-1 body weight) caused fever in both saline+LPS and DMSO+LPS group, but the onset and magnitude of the induced fever were significantly different. The saline+LPS group presented a prototypic biphasic fever whereas the DMSO+LPS group presented an attenuated febrile response, but it was not abolished. These results suggest that DMSO may provide a protective mechanism against pyrogen LPS, probably through the modulation of NF-kB mediated events, such as fever.
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spelling Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbitsLPSfeverDMSOrabbitsThe present study was designed to determine whether DMSO causes an inhibition on the development of fever in rabbits. The intravenous administration of LPS (1.5µg.kg-1 body weight) caused fever in both saline+LPS and DMSO+LPS group, but the onset and magnitude of the induced fever were significantly different. The saline+LPS group presented a prototypic biphasic fever whereas the DMSO+LPS group presented an attenuated febrile response, but it was not abolished. These results suggest that DMSO may provide a protective mechanism against pyrogen LPS, probably through the modulation of NF-kB mediated events, such as fever.Universidade Federal de Minas Gerais, Escola de Veterinária2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.60 n.3 2008reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG10.1590/S0102-09352008000300016info:eu-repo/semantics/openAccessSouza,A.H.Valadão,C.A.A.Selegatto,M.A.Almeida,R.M.Macari,M.eng2008-07-17T00:00:00Zoai:scielo:S0102-09352008000300016Revistahttps://www.scielo.br/j/abmvz/PUBhttps://old.scielo.br/oai/scielo-oai.phpjournal@vet.ufmg.br||abmvz.artigo@abmvz.org.br1678-41620102-0935opendoar:2008-07-17T00:00Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
title Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
spellingShingle Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
Souza,A.H.
LPS
fever
DMSO
rabbits
title_short Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
title_full Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
title_fullStr Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
title_full_unstemmed Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
title_sort Dimethyl sulfoxide effects on the febrile response to lipopolysaccharide injection in rabbits
author Souza,A.H.
author_facet Souza,A.H.
Valadão,C.A.A.
Selegatto,M.A.
Almeida,R.M.
Macari,M.
author_role author
author2 Valadão,C.A.A.
Selegatto,M.A.
Almeida,R.M.
Macari,M.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Souza,A.H.
Valadão,C.A.A.
Selegatto,M.A.
Almeida,R.M.
Macari,M.
dc.subject.por.fl_str_mv LPS
fever
DMSO
rabbits
topic LPS
fever
DMSO
rabbits
description The present study was designed to determine whether DMSO causes an inhibition on the development of fever in rabbits. The intravenous administration of LPS (1.5µg.kg-1 body weight) caused fever in both saline+LPS and DMSO+LPS group, but the onset and magnitude of the induced fever were significantly different. The saline+LPS group presented a prototypic biphasic fever whereas the DMSO+LPS group presented an attenuated febrile response, but it was not abolished. These results suggest that DMSO may provide a protective mechanism against pyrogen LPS, probably through the modulation of NF-kB mediated events, such as fever.
publishDate 2008
dc.date.none.fl_str_mv 2008-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000300016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-09352008000300016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
publisher.none.fl_str_mv Universidade Federal de Minas Gerais, Escola de Veterinária
dc.source.none.fl_str_mv Arquivo Brasileiro de Medicina Veterinária e Zootecnia v.60 n.3 2008
reponame:Arquivo brasileiro de medicina veterinária e zootecnia (Online)
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Arquivo brasileiro de medicina veterinária e zootecnia (Online)
collection Arquivo brasileiro de medicina veterinária e zootecnia (Online)
repository.name.fl_str_mv Arquivo brasileiro de medicina veterinária e zootecnia (Online) - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv journal@vet.ufmg.br||abmvz.artigo@abmvz.org.br
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