Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil

Detalhes bibliográficos
Autor(a) principal: Carolina Kymie Vasques Nonaka
Data de Publicação: 2021
Outros Autores: Renato Santana de Aguiar, Marta Giovanetti, Bruno Solano de Freitas Souza, Marília Miranda Franco, Tiago Gräf, Camila Araújo de Lorenzo Barcia, Renata Naves de Ávila Mendonça, Karoline Almeida Felix de Sousa, Leila Machado da Costa Neiva, Vagner Fosenca, Ana Verena Almeida Mendes
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://hdl.handle.net/1843/56356
https://orcid.org/0000-0002-5849-7326
https://orcid.org/0000-0003-3771-0439
https://orcid.org/0000-0003-4921-7975
https://orcid.org/0000-0002-5508-4235
https://orcid.org/0000-0002-7423-1309
https://orcid.org/0000-0002-4226-8625
https://orcid.org/0000-0003-3491-4903
https://orcid.org/0000-0002-4637-410X
Resumo: Uncertainty remains about how long the protective immune responses against severe acute respiratory syndrome coronavirus 2 persists, and suspected reinfection in recovered patients has been reported. We describe a case of reinfection from distinct virus lineages in Brazil harboring the E484K mutation, a variant associated with escape from neutralizing antibodies.
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spelling 2023-07-15T00:18:56Z2023-07-15T00:18:56Z20212751522152410.3201/eid2705.2101911080-6040http://hdl.handle.net/1843/56356https://orcid.org/0000-0002-5849-7326https://orcid.org/0000-0003-3771-0439https://orcid.org/0000-0003-4921-7975https://orcid.org/0000-0002-5508-4235https://orcid.org/0000-0002-7423-1309https://orcid.org/0000-0002-4226-8625https://orcid.org/0000-0003-3491-4903https://orcid.org/0000-0002-4637-410XUncertainty remains about how long the protective immune responses against severe acute respiratory syndrome coronavirus 2 persists, and suspected reinfection in recovered patients has been reported. We describe a case of reinfection from distinct virus lineages in Brazil harboring the E484K mutation, a variant associated with escape from neutralizing antibodies.porUniversidade Federal de Minas GeraisUFMGBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASEmerging Infectious DiseasesCOVID-19BrasilMutação (Biologia)BrazilSARS-CoV-2MutationGenomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://wwwnc.cdc.gov/eid/article/27/5/21-0191_articleCarolina Kymie Vasques NonakaRenato Santana de AguiarMarta GiovanettiBruno Solano de Freitas SouzaMarília Miranda FrancoTiago GräfCamila Araújo de Lorenzo BarciaRenata Naves de Ávila MendonçaKaroline Almeida Felix de SousaLeila Machado da Costa NeivaVagner FosencaAna Verena Almeida Mendesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56356/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALGenomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil.pdfGenomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil.pdfapplication/pdf8977358https://repositorio.ufmg.br/bitstream/1843/56356/2/Genomic%20Evidence%20of%20SARS-CoV-2%20Reinfection%20Involving%20E484K%20Spike%20Mutation%2c%20Brazil.pdf08c31276882c22e2306279653a245670MD521843/563562023-07-14 21:18:56.709oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-15T00:18:56Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil
title Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil
spellingShingle Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil
Carolina Kymie Vasques Nonaka
Brazil
SARS-CoV-2
Mutation
COVID-19
Brasil
Mutação (Biologia)
title_short Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil
title_full Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil
title_fullStr Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil
title_full_unstemmed Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil
title_sort Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil
author Carolina Kymie Vasques Nonaka
author_facet Carolina Kymie Vasques Nonaka
Renato Santana de Aguiar
Marta Giovanetti
Bruno Solano de Freitas Souza
Marília Miranda Franco
Tiago Gräf
Camila Araújo de Lorenzo Barcia
Renata Naves de Ávila Mendonça
Karoline Almeida Felix de Sousa
Leila Machado da Costa Neiva
Vagner Fosenca
Ana Verena Almeida Mendes
author_role author
author2 Renato Santana de Aguiar
Marta Giovanetti
Bruno Solano de Freitas Souza
Marília Miranda Franco
Tiago Gräf
Camila Araújo de Lorenzo Barcia
Renata Naves de Ávila Mendonça
Karoline Almeida Felix de Sousa
Leila Machado da Costa Neiva
Vagner Fosenca
Ana Verena Almeida Mendes
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carolina Kymie Vasques Nonaka
Renato Santana de Aguiar
Marta Giovanetti
Bruno Solano de Freitas Souza
Marília Miranda Franco
Tiago Gräf
Camila Araújo de Lorenzo Barcia
Renata Naves de Ávila Mendonça
Karoline Almeida Felix de Sousa
Leila Machado da Costa Neiva
Vagner Fosenca
Ana Verena Almeida Mendes
dc.subject.por.fl_str_mv Brazil
SARS-CoV-2
Mutation
topic Brazil
SARS-CoV-2
Mutation
COVID-19
Brasil
Mutação (Biologia)
dc.subject.other.pt_BR.fl_str_mv COVID-19
Brasil
Mutação (Biologia)
description Uncertainty remains about how long the protective immune responses against severe acute respiratory syndrome coronavirus 2 persists, and suspected reinfection in recovered patients has been reported. We describe a case of reinfection from distinct virus lineages in Brazil harboring the E484K mutation, a variant associated with escape from neutralizing antibodies.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2023-07-15T00:18:56Z
dc.date.available.fl_str_mv 2023-07-15T00:18:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/56356
dc.identifier.doi.pt_BR.fl_str_mv 10.3201/eid2705.210191
dc.identifier.issn.pt_BR.fl_str_mv 1080-6040
dc.identifier.orcid.pt_BR.fl_str_mv https://orcid.org/0000-0002-5849-7326
https://orcid.org/0000-0003-3771-0439
https://orcid.org/0000-0003-4921-7975
https://orcid.org/0000-0002-5508-4235
https://orcid.org/0000-0002-7423-1309
https://orcid.org/0000-0002-4226-8625
https://orcid.org/0000-0003-3491-4903
https://orcid.org/0000-0002-4637-410X
identifier_str_mv 10.3201/eid2705.210191
1080-6040
url http://hdl.handle.net/1843/56356
https://orcid.org/0000-0002-5849-7326
https://orcid.org/0000-0003-3771-0439
https://orcid.org/0000-0003-4921-7975
https://orcid.org/0000-0002-5508-4235
https://orcid.org/0000-0002-7423-1309
https://orcid.org/0000-0002-4226-8625
https://orcid.org/0000-0003-3491-4903
https://orcid.org/0000-0002-4637-410X
dc.language.iso.fl_str_mv por
language por
dc.relation.ispartof.pt_BR.fl_str_mv Emerging Infectious Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/56356/1/License.txt
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