Vision-related quality of life and depression in in brazilian patients with toxoplasmic retinochoroiditis

• Autor(a) principal: Jacqueline Souza Dutra Arruda
• Data de Publicação: 2021
• Outros Autores: Jacqueline Domingues Tibúrcio, Salvina Maria de Campos Carli, Antônio Lucio Teixeira, Daniel Vítor de Vasconcelos Santos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.1016/j.ijid.2021.08.051; http://hdl.handle.net/1843/54938; https://orcid.org/0000-0002-4171-8110; https://orcid.org/0000-0002-4336-0140; https://orcid.org/0000-0002-9621-5422; https://orcid.org/0000-0002-6747-2024
• topic: Ocular toxoplasmosis; Uveitis; Quality of life; Depression; Toxoplasmose ocular; Uveíte; Qualidade de vida; Depressão

Purpose: To investigate visual-related quality of life (VRQL) and prevalence and severity of depressive symptoms in Brazilian individuals with toxoplasmic retinochoroiditis (TRC). Design: Comparative observational cross-sectional study. The National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25) and Beck Depression Inventory-II (BDI-II) were applied to respectively assess VRQL and depression in individuals consecutively seen at a uveitis referral center. Clinical/demographical data were collected. Descriptive/analytic statistics were employed, with P<0.05. Results: Patients and controls were comparable concerning age, sex and socioeconomic level. VRQL scores for all subscales were significantly lower in TRC when compared with controls, particularly associated (P<0.05) with female sex, history of ≥2 prior TRC recurrences, concomitant use of systemic corticosteroids, monocular vision and blindness. Depressive symptoms were more prevalent in TRC (55/188; 29.2%) than in controls (34/182; 18.7%) (P=0.023), also being associated with lower VRQL scores (P<0.001). Seropositive and seronegative controls for toxoplasmosis had similar VRQL scores and comparable rates of depressive symptoms. Conclusion: TRC affects VRQL in Brazilian individuals, particularly women, using systemic corticosteroids, with visual impairment and presenting recurrences of TRC. One-third of patients with TRC had evidence of depression, which was also associated with lower VRQL scores. Mental health issues in subjects with TRC should not be overlooked.