Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.3389/fmicb.2022.799713 http://hdl.handle.net/1843/60394 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2023-10-31T21:33:38Z2023-10-31T21:33:38Z20221379971312https://doi.org/10.3389/fmicb.2022.7997131664-302Xhttp://hdl.handle.net/1843/60394CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e ProjetosFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de JaneiroThe COVID-19 pandemic has created an unprecedented need for epidemiological monitoring using diverse strategies. We conducted a project combining prevalence, seroprevalence, and genomic surveillance approaches to describe the initial pandemic stages in Betim City, Brazil. We collected 3239 subjects in a population-based age-, sex- and neighborhood-stratified, household, prospective; cross-sectional study divided into three surveys 21 days apart sampling the same geographical area. In the first survey, overall prevalence (participants positive in serological or molecular tests) reached 0.46% (90% CI 0.12–0.80%), followed by 2.69% (90% CI 1.88–3.49%) in the second survey and 6.67% (90% CI 5.42–7.92%) in the third. The underreporting reached 11, 19.6, and 20.4 times in each survey. We observed increased odds to test positive in females compared to males (OR 1.88 95% CI 1.25–2.82), while the single best predictor for positivity was ageusia/anosmia (OR 8.12, 95% CI 4.72–13.98). Thirty-five SARS-CoV-2 genomes were sequenced, of which 18 were classified as lineage B.1.1.28, while 17 were B.1.1.33. Multiple independent viral introductions were observed. Integration of multiple epidemiological strategies was able to adequately describe COVID-19 dispersion in the city. Presented results have helped local government authorities to guide pandemic management.engUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE BOTÂNICAICB - INSTITUTO DE CIÊNCIAS BIOLOGICASFrontiers in MicrobiologyCOVID-19SARS-CoV-2GenomasPandemiaCOVID-19SARS-CoV-2GenomasPandemiaSeroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/articles/10.3389/fmicb.2022.799713/fullAna Valesca Fernandes GilsonsilvaAdriano Neves CoelhoJúlia Maria Saraiva DuarteAugusto Viana da RochaLuiz Gonzaga Paula de AlmeidaJoão Locke Ferreira de AraújoHilton Soares de OliveiraNova Jersey Cláudio de OliveiraCamila ZoliniJôsy Hubner de SousaElizângela Gonçalves de SouzaDiego MenezesRafael Marques de SouzaLuciana de Lima FerreiraAlexandra Lehmkuhl GerberAna Paula de Campos GuimarãesPaulo Henrique Silva MaiaFernanda Martins MarimLucyene MiguitaCristiane Campos MonteiroTuffi Saliba NetoFabrícia Soares Freire PugêdoFilipe Romero Rebello MoreiraDaniel Costa QueirozDamares Nigia Alborguetti Cuzzuol QueirozLuciana Cunha Resende-MoreiraFranciele Martins SantosErika Fernanda Carlos SouzaCarolina Moreira VolochAna Tereza VasconcelosRenato Santana de AguiarRenan Pedra de SouzaOctávio Alcântara TorresPaula Luize Camargos FonsecaRennan Garcias MoreiraHugo José AlvesVivian Ribeiro AlvesTânia Maria de Resende Amaralapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/60394/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALSeroprevalence, Prevalence, and Genomic Surveillance_ Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil.pdfSeroprevalence, Prevalence, and Genomic Surveillance_ Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil.pdfapplication/pdf609068https://repositorio.ufmg.br/bitstream/1843/60394/2/Seroprevalence%2c%20Prevalence%2c%20and%20Genomic%20Surveillance_%20Monitoring%20the%20Initial%20Phases%20of%20the%20SARS-CoV-2%20Pandemic%20in%20Betim%2c%20Brazil.pdfe02124205f30690e9553bba7a4012e5fMD521843/603942023-10-31 18:33:38.422oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-10-31T21:33:38Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil |
| title |
Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil |
| spellingShingle |
Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil Ana Valesca Fernandes Gilsonsilva COVID-19 SARS-CoV-2 Genomas Pandemia COVID-19 SARS-CoV-2 Genomas Pandemia |
| title_short |
Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil |
| title_full |
Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil |
| title_fullStr |
Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil |
| title_full_unstemmed |
Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil |
| title_sort |
Seroprevalence, Prevalence, and Genomic Surveillance: Monitoring the Initial Phases of the SARS-CoV-2 Pandemic in Betim, Brazil |
| author |
Ana Valesca Fernandes Gilsonsilva |
| author_facet |
Ana Valesca Fernandes Gilsonsilva Adriano Neves Coelho Júlia Maria Saraiva Duarte Augusto Viana da Rocha Luiz Gonzaga Paula de Almeida João Locke Ferreira de Araújo Hilton Soares de Oliveira Nova Jersey Cláudio de Oliveira Camila Zolini Jôsy Hubner de Sousa Elizângela Gonçalves de Souza Diego Menezes Rafael Marques de Souza Luciana de Lima Ferreira Alexandra Lehmkuhl Gerber Ana Paula de Campos Guimarães Paulo Henrique Silva Maia Fernanda Martins Marim Lucyene Miguita Cristiane Campos Monteiro Tuffi Saliba Neto Fabrícia Soares Freire Pugêdo Filipe Romero Rebello Moreira Daniel Costa Queiroz Damares Nigia Alborguetti Cuzzuol Queiroz Luciana Cunha Resende-Moreira Franciele Martins Santos Erika Fernanda Carlos Souza Carolina Moreira Voloch Ana Tereza Vasconcelos Renato Santana de Aguiar Renan Pedra de Souza Octávio Alcântara Torres Paula Luize Camargos Fonseca Rennan Garcias Moreira Hugo José Alves Vivian Ribeiro Alves Tânia Maria de Resende Amaral |
| author_role |
author |
| author2 |
Adriano Neves Coelho Júlia Maria Saraiva Duarte Augusto Viana da Rocha Luiz Gonzaga Paula de Almeida João Locke Ferreira de Araújo Hilton Soares de Oliveira Nova Jersey Cláudio de Oliveira Camila Zolini Jôsy Hubner de Sousa Elizângela Gonçalves de Souza Diego Menezes Rafael Marques de Souza Luciana de Lima Ferreira Alexandra Lehmkuhl Gerber Ana Paula de Campos Guimarães Paulo Henrique Silva Maia Fernanda Martins Marim Lucyene Miguita Cristiane Campos Monteiro Tuffi Saliba Neto Fabrícia Soares Freire Pugêdo Filipe Romero Rebello Moreira Daniel Costa Queiroz Damares Nigia Alborguetti Cuzzuol Queiroz Luciana Cunha Resende-Moreira Franciele Martins Santos Erika Fernanda Carlos Souza Carolina Moreira Voloch Ana Tereza Vasconcelos Renato Santana de Aguiar Renan Pedra de Souza Octávio Alcântara Torres Paula Luize Camargos Fonseca Rennan Garcias Moreira Hugo José Alves Vivian Ribeiro Alves Tânia Maria de Resende Amaral |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ana Valesca Fernandes Gilsonsilva Adriano Neves Coelho Júlia Maria Saraiva Duarte Augusto Viana da Rocha Luiz Gonzaga Paula de Almeida João Locke Ferreira de Araújo Hilton Soares de Oliveira Nova Jersey Cláudio de Oliveira Camila Zolini Jôsy Hubner de Sousa Elizângela Gonçalves de Souza Diego Menezes Rafael Marques de Souza Luciana de Lima Ferreira Alexandra Lehmkuhl Gerber Ana Paula de Campos Guimarães Paulo Henrique Silva Maia Fernanda Martins Marim Lucyene Miguita Cristiane Campos Monteiro Tuffi Saliba Neto Fabrícia Soares Freire Pugêdo Filipe Romero Rebello Moreira Daniel Costa Queiroz Damares Nigia Alborguetti Cuzzuol Queiroz Luciana Cunha Resende-Moreira Franciele Martins Santos Erika Fernanda Carlos Souza Carolina Moreira Voloch Ana Tereza Vasconcelos Renato Santana de Aguiar Renan Pedra de Souza Octávio Alcântara Torres Paula Luize Camargos Fonseca Rennan Garcias Moreira Hugo José Alves Vivian Ribeiro Alves Tânia Maria de Resende Amaral |
| dc.subject.por.fl_str_mv |
COVID-19 SARS-CoV-2 Genomas Pandemia |
| topic |
COVID-19 SARS-CoV-2 Genomas Pandemia COVID-19 SARS-CoV-2 Genomas Pandemia |
| dc.subject.other.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 Genomas Pandemia |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022 |
| dc.date.issued.fl_str_mv |
2022 |
| dc.date.accessioned.fl_str_mv |
2023-10-31T21:33:38Z |
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2023-10-31T21:33:38Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/60394 |
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https://doi.org/10.3389/fmicb.2022.799713 |
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1664-302X |
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https://doi.org/10.3389/fmicb.2022.799713 http://hdl.handle.net/1843/60394 |
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1664-302X |
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eng |
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eng |
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Frontiers in Microbiology |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICB - DEPARTAMENTO DE BOTÂNICA ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS |
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Universidade Federal de Minas Gerais |
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