Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.1371/journal.pntd.0006525 http://hdl.handle.net/1843/56301 https://orcid.org/0000-0002-0828-9879 https://orcid.org/0000-0003-1957-666X https://orcid.org/0000-0001-8198-6016 https://orcid.org/0000-0002-8242-5584 https://orcid.org/0000-0002-1406-6401 https://orcid.org/0000-0003-3432-0769 https://orcid.org/0000-0002-6944-3008 https://orcid.org/0000-0003-1102-2419 https://orcid.org/0000-0003-0875-2269 https://orcid.org/0000-0001-5105-9537 https://orcid.org/0000-0002-4177-7532 https://orcid.org/0000-0001-8585-8206 |
Resumo: | The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto. |
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2023-07-14T20:36:33Z2023-07-14T20:36:33Z2018125125https://doi.org/10.1371/journal.pntd.00065251935-2735http://hdl.handle.net/1843/56301https://orcid.org/0000-0002-0828-9879https://orcid.org/0000-0003-1957-666Xhttps://orcid.org/0000-0001-8198-6016https://orcid.org/0000-0002-8242-5584https://orcid.org/0000-0002-1406-6401https://orcid.org/0000-0003-3432-0769https://orcid.org/0000-0002-6944-3008https://orcid.org/0000-0003-1102-2419https://orcid.org/0000-0003-0875-2269https://orcid.org/0000-0001-5105-9537https://orcid.org/0000-0002-4177-7532https://orcid.org/0000-0001-8585-8206The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto.porUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAICB - DEPARTAMENTO DE FARMACOLOGIAICB - DEPARTAMENTO DE MICROBIOLOGIAPLOS Neglected Tropical DiseasesDengue - EpidemiologiaSão Jose do Rio Preto, Região de (SP)Dengue virus (DENV)São José do Rio Preto, BrazilGenotype VEpidemicsViral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006525Tauyne Menegaldo PinheiroBárbara Aparecida ChavesMayara Marques Carneiro da SilvaIzabella Cristina Andrade BatistaMichelle Premazzi PapaLana Monteiro MeurenCarolina Gonçalves de Oliveira LucasFlavio Lemos MatassoliLaura Helena Vega Gonzales GilAdriana BozziCarlos Eduardo Calzavara SilvaMânlio Tasso de Oliveira MotaLuciana Barros de ArrudaDanielle da Glória de SouzaMauro Martins TeixeiraNikos VasilakisMaurício Lacerda NogueiraAripuanã Sakurada Aranha WatanabeJoice Matos Biselli PéricoBetânia Paiva DrumondMilene Rocha RibeiroDanila VedovelloJoão Pessoa AraújoPaulo Filemon Paolucci Pimentainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56301/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALViral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil.pdfViral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil.pdfapplication/pdf3595812https://repositorio.ufmg.br/bitstream/1843/56301/2/Viral%20immunogenicity%20determines%20epidemiological%20fitness%20in%20a%20cohort%20of%20DENV-1%20infection%20in%20Brazil.pdf7cfaf5b07ad0c9d91dff6a12861f18aeMD521843/563012023-07-14 17:36:33.417oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-14T20:36:33Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
title |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
spellingShingle |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil Tauyne Menegaldo Pinheiro Dengue virus (DENV) São José do Rio Preto, Brazil Genotype V Epidemics Dengue - Epidemiologia São Jose do Rio Preto, Região de (SP) |
title_short |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
title_full |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
title_fullStr |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
title_full_unstemmed |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
title_sort |
Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
author |
Tauyne Menegaldo Pinheiro |
author_facet |
Tauyne Menegaldo Pinheiro Bárbara Aparecida Chaves Mayara Marques Carneiro da Silva Izabella Cristina Andrade Batista Michelle Premazzi Papa Lana Monteiro Meuren Carolina Gonçalves de Oliveira Lucas Flavio Lemos Matassoli Laura Helena Vega Gonzales Gil Adriana Bozzi Carlos Eduardo Calzavara Silva Mânlio Tasso de Oliveira Mota Luciana Barros de Arruda Danielle da Glória de Souza Mauro Martins Teixeira Nikos Vasilakis Maurício Lacerda Nogueira Aripuanã Sakurada Aranha Watanabe Joice Matos Biselli Périco Betânia Paiva Drumond Milene Rocha Ribeiro Danila Vedovello João Pessoa Araújo Paulo Filemon Paolucci Pimenta |
author_role |
author |
author2 |
Bárbara Aparecida Chaves Mayara Marques Carneiro da Silva Izabella Cristina Andrade Batista Michelle Premazzi Papa Lana Monteiro Meuren Carolina Gonçalves de Oliveira Lucas Flavio Lemos Matassoli Laura Helena Vega Gonzales Gil Adriana Bozzi Carlos Eduardo Calzavara Silva Mânlio Tasso de Oliveira Mota Luciana Barros de Arruda Danielle da Glória de Souza Mauro Martins Teixeira Nikos Vasilakis Maurício Lacerda Nogueira Aripuanã Sakurada Aranha Watanabe Joice Matos Biselli Périco Betânia Paiva Drumond Milene Rocha Ribeiro Danila Vedovello João Pessoa Araújo Paulo Filemon Paolucci Pimenta |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Tauyne Menegaldo Pinheiro Bárbara Aparecida Chaves Mayara Marques Carneiro da Silva Izabella Cristina Andrade Batista Michelle Premazzi Papa Lana Monteiro Meuren Carolina Gonçalves de Oliveira Lucas Flavio Lemos Matassoli Laura Helena Vega Gonzales Gil Adriana Bozzi Carlos Eduardo Calzavara Silva Mânlio Tasso de Oliveira Mota Luciana Barros de Arruda Danielle da Glória de Souza Mauro Martins Teixeira Nikos Vasilakis Maurício Lacerda Nogueira Aripuanã Sakurada Aranha Watanabe Joice Matos Biselli Périco Betânia Paiva Drumond Milene Rocha Ribeiro Danila Vedovello João Pessoa Araújo Paulo Filemon Paolucci Pimenta |
dc.subject.por.fl_str_mv |
Dengue virus (DENV) São José do Rio Preto, Brazil Genotype V Epidemics |
topic |
Dengue virus (DENV) São José do Rio Preto, Brazil Genotype V Epidemics Dengue - Epidemiologia São Jose do Rio Preto, Região de (SP) |
dc.subject.other.pt_BR.fl_str_mv |
Dengue - Epidemiologia São Jose do Rio Preto, Região de (SP) |
description |
The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2023-07-14T20:36:33Z |
dc.date.available.fl_str_mv |
2023-07-14T20:36:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56301 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1371/journal.pntd.0006525 |
dc.identifier.issn.pt_BR.fl_str_mv |
1935-2735 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-0828-9879 https://orcid.org/0000-0003-1957-666X https://orcid.org/0000-0001-8198-6016 https://orcid.org/0000-0002-8242-5584 https://orcid.org/0000-0002-1406-6401 https://orcid.org/0000-0003-3432-0769 https://orcid.org/0000-0002-6944-3008 https://orcid.org/0000-0003-1102-2419 https://orcid.org/0000-0003-0875-2269 https://orcid.org/0000-0001-5105-9537 https://orcid.org/0000-0002-4177-7532 https://orcid.org/0000-0001-8585-8206 |
url |
https://doi.org/10.1371/journal.pntd.0006525 http://hdl.handle.net/1843/56301 https://orcid.org/0000-0002-0828-9879 https://orcid.org/0000-0003-1957-666X https://orcid.org/0000-0001-8198-6016 https://orcid.org/0000-0002-8242-5584 https://orcid.org/0000-0002-1406-6401 https://orcid.org/0000-0003-3432-0769 https://orcid.org/0000-0002-6944-3008 https://orcid.org/0000-0003-1102-2419 https://orcid.org/0000-0003-0875-2269 https://orcid.org/0000-0001-5105-9537 https://orcid.org/0000-0002-4177-7532 https://orcid.org/0000-0001-8585-8206 |
identifier_str_mv |
1935-2735 |
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PLOS Neglected Tropical Diseases |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE MICROBIOLOGIA |
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Universidade Federal de Minas Gerais |
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