Effect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.3389/fphys.2019.01168 http://hdl.handle.net/1843/42594 https://orcid.org/0000-0002-1696-6091 https://orcid.org/ 0000-0003-0420-445X https://orcid.org/ 0000-0001-6358-4910 http://orcid.org/0000-0001-8977-8131 http://orcid.org/0000-0003-2719-4231 http://orcid.org/0000-0001-8981-6724 https://orcid.org/ 0000-0002-8658-3774 https://orcid.org/ 0000-0002-4718-448X https://orcid.org/ 0000-0001-5366-3754 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-06-22T14:28:39Z2022-06-22T14:28:39Z2019-09101168110https://doi.org/10.3389/fphys.2019.011681664-042Xhttp://hdl.handle.net/1843/42594https://orcid.org/0000-0002-1696-6091https://orcid.org/ 0000-0003-0420-445Xhttps://orcid.org/ 0000-0001-6358-4910http://orcid.org/0000-0001-8977-8131http://orcid.org/0000-0003-2719-4231http://orcid.org/0000-0001-8981-6724https://orcid.org/ 0000-0002-8658-3774https://orcid.org/ 0000-0002-4718-448Xhttps://orcid.org/ 0000-0001-5366-3754CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorBackground: Knee osteoarthritis (kOA) is a common chronic disease that induces changes in redox status and inflammatory biomarkers, cell death, and motor impairment. Aerobic training can be a non-pharmacological alternative to prevent the progression of the disease. Objective: To evaluate the effects of an 8 weeks moderate-intensity treadmill aerobic training program on redox status and inflammatory biomarkers and motor performance in kOA-like changes induced by monosodium iodoacetate (MIA) in rats. Methods: Twenty-seven rats were randomly divided into three groups: SHAM; induced kOA (OA); and induced kOA + aerobic training (OAE). Motor performance was evaluated by the number of falls on rotarod test, the total time of displacement and the number of failures on a 100 cm footbridge. Data for cytokines and histology were investigated locally, whereas plasma was used for redox status biomarkers. Results: The OA group, compared to the SHAM group, increased 1.13 times the total time of displacement, 6.05 times the number of failures, 2.40 times the number of falls. There was also an increase in cytokine and in thiobarbituric acid reactive substances (TBARS) (IL1β: 5.55-fold, TNF: 2.84-fold, IL10: 1.27-fold, IL6: 1.50-fold, TBARS: 1.14-fold), and a reduction of 6.83% in the total antioxidant capacity (FRAP), and of 35% in the number of chondrocytes. The aerobic training improved the motor performance in all joint function tests matching to SHAM scores. Also, it reduced inflammatory biomarkers and TBARS level at values close to those of the SHAM group, with no change in FRAP level. The number of falls was explained by IL1β and TNF (58%), and the number of failures and the total time of displacement were also explained by TNF (29 and 21%, respectively). Conclusion: All findings indicate the efficacy of moderate-intensity aerobic training to regulate inflammatory biomarkers associated with improved motor performance in induced kOA-like changes, thus preventing the loss of chondrocytes.engUniversidade Federal de Minas GeraisUFMGBrasilEEF - DEPARTAMENTO DE FISIOTERAPIAICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICAICB - DEPARTAMENTO DE MORFOLOGIAFrontiers in PhysiologyOsteoartriteExercícios aeróbicosBiomarcadoresArticulações - Aspectos fisiológicosRatosOsteoarthritisAerobic trainingExerciseBiomarkersJoint functionEffect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/articles/10.3389/fphys.2019.01168/fullJeanne Brenda MartinsVanessa Amaral MendonçaGrazielle Cordeiro AguiarSueli Ferreira da FonsecaJousielle Márcia dos SantosRosalina Tossige GomesDirceu de Sousa MeloMurilo Xavier OliveiraHércules Ribeiro LeiteAna Cristina Resende CamargosAnderson José FerreiraCândido Celso CoimbraJacques PoortmansVinícius Cunha OliveiraSara Barros SilvaTalita Emanuela DominguesMario Bernardo FilhoAna Cristina Rodrigues Lacerdaapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/42594/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALEffect of a Moderate-Intensity Aerobic Training on Joint Biomarkers and Functional Adaptations in Rats.pdfEffect of a Moderate-Intensity Aerobic Training on Joint Biomarkers and Functional Adaptations in Rats.pdfapplication/pdf1076627https://repositorio.ufmg.br/bitstream/1843/42594/2/Effect%20of%20a%20Moderate-Intensity%20Aerobic%20Training%20on%20Joint%20Biomarkers%20and%20Functional%20Adaptations%20in%20Rats.pdfda079cfd2492bdbdfbed4304a00a1aceMD521843/425942022-06-22 11:28:39.721oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-06-22T14:28:39Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Effect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritis |
| title |
Effect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritis |
| spellingShingle |
Effect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritis Jeanne Brenda Martins Osteoarthritis Aerobic training Exercise Biomarkers Joint function Osteoartrite Exercícios aeróbicos Biomarcadores Articulações - Aspectos fisiológicos Ratos |
| title_short |
Effect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritis |
| title_full |
Effect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritis |
| title_fullStr |
Effect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritis |
| title_full_unstemmed |
Effect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritis |
| title_sort |
Effect of a moderate-intensity aerobic training on joint biomarkers and functional adaptations in rats subjected to induced knee osteoarthritis |
| author |
Jeanne Brenda Martins |
| author_facet |
Jeanne Brenda Martins Vanessa Amaral Mendonça Grazielle Cordeiro Aguiar Sueli Ferreira da Fonseca Jousielle Márcia dos Santos Rosalina Tossige Gomes Dirceu de Sousa Melo Murilo Xavier Oliveira Hércules Ribeiro Leite Ana Cristina Resende Camargos Anderson José Ferreira Cândido Celso Coimbra Jacques Poortmans Vinícius Cunha Oliveira Sara Barros Silva Talita Emanuela Domingues Mario Bernardo Filho Ana Cristina Rodrigues Lacerda |
| author_role |
author |
| author2 |
Vanessa Amaral Mendonça Grazielle Cordeiro Aguiar Sueli Ferreira da Fonseca Jousielle Márcia dos Santos Rosalina Tossige Gomes Dirceu de Sousa Melo Murilo Xavier Oliveira Hércules Ribeiro Leite Ana Cristina Resende Camargos Anderson José Ferreira Cândido Celso Coimbra Jacques Poortmans Vinícius Cunha Oliveira Sara Barros Silva Talita Emanuela Domingues Mario Bernardo Filho Ana Cristina Rodrigues Lacerda |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Jeanne Brenda Martins Vanessa Amaral Mendonça Grazielle Cordeiro Aguiar Sueli Ferreira da Fonseca Jousielle Márcia dos Santos Rosalina Tossige Gomes Dirceu de Sousa Melo Murilo Xavier Oliveira Hércules Ribeiro Leite Ana Cristina Resende Camargos Anderson José Ferreira Cândido Celso Coimbra Jacques Poortmans Vinícius Cunha Oliveira Sara Barros Silva Talita Emanuela Domingues Mario Bernardo Filho Ana Cristina Rodrigues Lacerda |
| dc.subject.por.fl_str_mv |
Osteoarthritis Aerobic training Exercise Biomarkers Joint function |
| topic |
Osteoarthritis Aerobic training Exercise Biomarkers Joint function Osteoartrite Exercícios aeróbicos Biomarcadores Articulações - Aspectos fisiológicos Ratos |
| dc.subject.other.pt_BR.fl_str_mv |
Osteoartrite Exercícios aeróbicos Biomarcadores Articulações - Aspectos fisiológicos Ratos |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2019 |
| dc.date.issued.fl_str_mv |
2019-09 |
| dc.date.accessioned.fl_str_mv |
2022-06-22T14:28:39Z |
| dc.date.available.fl_str_mv |
2022-06-22T14:28:39Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/42594 |
| dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3389/fphys.2019.01168 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1664-042X |
| dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-1696-6091 https://orcid.org/ 0000-0003-0420-445X https://orcid.org/ 0000-0001-6358-4910 http://orcid.org/0000-0001-8977-8131 http://orcid.org/0000-0003-2719-4231 http://orcid.org/0000-0001-8981-6724 https://orcid.org/ 0000-0002-8658-3774 https://orcid.org/ 0000-0002-4718-448X https://orcid.org/ 0000-0001-5366-3754 |
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https://doi.org/10.3389/fphys.2019.01168 http://hdl.handle.net/1843/42594 https://orcid.org/0000-0002-1696-6091 https://orcid.org/ 0000-0003-0420-445X https://orcid.org/ 0000-0001-6358-4910 http://orcid.org/0000-0001-8977-8131 http://orcid.org/0000-0003-2719-4231 http://orcid.org/0000-0001-8981-6724 https://orcid.org/ 0000-0002-8658-3774 https://orcid.org/ 0000-0002-4718-448X https://orcid.org/ 0000-0001-5366-3754 |
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1664-042X |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Frontiers in Physiology |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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EEF - DEPARTAMENTO DE FISIOTERAPIA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA ICB - DEPARTAMENTO DE MORFOLOGIA |
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Universidade Federal de Minas Gerais |
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