| spelling |
2023-06-20T19:22:11Z2023-06-20T19:22:11Z20211112http://dx.doi.org/10.1136/bmjopen-2021-0512842044-6055http://hdl.handle.net/1843/55169https://orcid.org/0000-0001-8280-3234https://orcid.org/0000-0002-9075-9269https://orcid.org/0000-0002-5739-0009https://orcid.org/0000-0003-3048-2250https://orcid.org/0000-0002-2630-9909https://orcid.org/0000-0001-9863-9993https://orcid.org/0000-0003-0268-3303https://orcid.org/0000-0002-4376-8189https://orcid.org/0000-0002-7356-8428https://orcid.org/0000-0003-4335-0337https://orcid.org/0000-0001-9406-4256https://orcid.org/0000-0001-7133-0574https://orcid.org/0000-0001-6270-6269https://orcid.org/0000-0003-4851-6949https://orcid.org/0000-0003-4014-6277https://orcid.org/0000-0003-0565-9747https://orcid.org/0000-0002-6975-6231https://orcid.org/0000-0003-1405-5371https://orcid.org/0000-0002-6856-8327https://orcid.org/0000-0001-8100-1926https://orcid.org/0000-0001-9278-6861https://orcid.org/0000-0001-8352-8983https://orcid.org/0000-0002-5590-108Xhttps://orcid.org/0000-0002-3648-6159https://orcid.org/0000-0003-4198-0546https://orcid.org/0000-0003-1386-7001https://orcid.org/0000-0003-1285-8445Introduction: The aim of this study was to evaluate the clinical, epidemiological and laboratory aspects of SARSCoV-2 infection during pregnancy and postpartum in 16 maternity hospitals. Methods and analysis: A prospective multicentre study, with five axes. First, the prevalence of SARS-CoV-2 infection among women admitted for childbirth will be described in a cross-sectional study. Second, maternal and perinatal outcomes will be assessed in a prospective cohort study including pregnant or postpartum women with suspected COVID-19. Third, a cohort of positive COVID-19 cases with sampling of a variety of biological material. Histopathological and viral analysis of biological maternal and neonatal samples will be performed, and the assessment of nutritional variables to evaluate the association between vitamin D and severity of infection. Fourth, a monitoring and evaluation committee to collect relevant healthcare information and plan actions in centres facing the pandemic. Furthermore, qualitative studies will be performed to study pregnant women, their families and health professionals. Fifth, an ecological study will monitor the number of live births, stillbirths and other outcomes to explore any trend among the periods before, during and after the pandemic. Data will systematically be collected in an electronic platform following standardised operational procedures. For quantitative study components, an appropriate statistical approach will be used for each analysis. For qualitative data, in-depth interviews recorded in audio will be transcribed, checking the text obtained with the recording. Subsequently, thematic analysis with the aid of the NVivo programme will be performed.Introdução: O objetivo deste estudo foi avaliar os aspectos clínicos, epidemiológicos e laboratoriais da infecção por SARSCoV-2 durante a gravidez e puerpério em 16 maternidades. Métodos e análise: Estudo prospectivo multicêntrico, com cinco eixos. Primeiro, a prevalência da infecção por SARS-CoV-2 entre mulheres admitidas para o parto será descrita em um estudo transversal. Em segundo lugar, os resultados maternos e perinatais serão avaliados em um estudo de coorte prospectivo, incluindo gestantes ou puérperas com suspeita de COVID-19. Em terceiro lugar, uma coorte de casos positivos de COVID-19 com amostragem de uma variedade de material biológico. Serão realizadas análises histopatológicas e virais de amostras biológicas maternas e neonatais, e avaliação de variáveis nutricionais para avaliar a associação entre vitamina D e gravidade da infecção. Em quarto lugar, um comitê de monitoramento e avaliação para coletar informações relevantes sobre saúde e planejar ações em centros que enfrentam a pandemia. Além disso, estudos qualitativos serão realizados para estudar mulheres grávidas, suas famílias e profissionais de saúde. Quinto, um estudo ecológico monitorará o número de nascidos vivos, natimortos e outros resultados para explorar qualquer tendência entre os períodos antes, durante e depois da pandemia. Os dados serão coletados sistematicamente em uma plataforma eletrônica seguindo procedimentos operacionais padronizados. Para componentes de estudo quantitativo, uma abordagem estatística apropriada será usada para cada análise. Para dados qualitativos, serão transcritas entrevistas em profundidade gravadas em áudio, verificando o texto obtido com a gravação. Posteriormente, será realizada a análise temática com o auxílio do programa NVivo.Outra AgênciaengUniversidade Federal de Minas GeraisUFMGBrasilHCL - HOSPITAL DAS CLINICASMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIABMJ OpenCOVID-19 (Doença)SARS-CoV-2MaternidadesGravidezPeríodo pós-partoSARSCoV-2COVID-19PregnancyPostpartumMaternity hospitalsBrazilian network of COVID-19 during pregnancy (REBRACO: a multicentre study protocol)Rede brasileira de COVID-19 durante gravidez (REBRACO: um estudo multicêntrico protocolo de estudo)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://bmjopen.bmj.com/content/11/12/e051284Maria Laura CostaRenato Teixeira SouzaRodolfo de Carvalho PacagnellaSilvana Aparecida Ferreira BentoCarolina Carvalho Ribeiro do ValleAdriana Gomes LuzGiuliane Jesus LajosSílvia de Barros MazonLuis Guillermo BahamondesFernanda Garanhani de Castro SuritaGuilherme de Moraes NobregaThayna Batalhoto GriggioCharles M'poca CharlesMaria Julia de Oliveira MieleRicardo Porto TedescoKarayna Gil FernandesSergio Hofmeister de Almeida Martins CostaFrederico José Amedee PeretFrancisco Edson de Lucena FeitosaRosiane MattarÉvelyn TrainaEdson Vieira da Cunha FilhoJanete VettorazziSamira El Maerrawi Tebecherane HaddadCarla Betina Andreucci PolidoJosé Paulo de Siqueira GuidaMário Dias Corrêa JúniorMarcos Augusto Bastos DiasLeandro Gustavo de OliveiraElias Ferreira de Melo JuniorCarlos Augusto Santos de MenezesMarília Gabriela Queiroz da LuzJose Guilherme Cecattiapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/55169/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALBrazilian network of COVID-19 during pregnancy (REBRACO a multicentre study protocol).pdfBrazilian network of COVID-19 during pregnancy (REBRACO a multicentre study protocol).pdfapplication/pdf534594https://repositorio.ufmg.br/bitstream/1843/55169/2/Brazilian%20network%20of%20COVID-19%20during%20pregnancy%20%28REBRACO%20a%20multicentre%20study%20protocol%29.pdfe14285f22c23fe63ff73f1e9373fc0fcMD521843/551692023-06-20 16:22:11.483oai:repositorio.ufmg.br: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Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-06-20T19:22:11Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
|