Brazilian network of COVID-19 during pregnancy (REBRACO: a multicentre study protocol)

• Main Author: Maria Laura Costa
• Publication Date: 2021
• Other Authors: Renato Teixeira Souza, Rodolfo de Carvalho Pacagnella, Silvana Aparecida Ferreira Bento, Carolina Carvalho Ribeiro do Valle, Adriana Gomes Luz, Giuliane Jesus Lajos, Sílvia de Barros Mazon, Luis Guillermo Bahamondes, Fernanda Garanhani de Castro Surita, Guilherme de Moraes Nobrega, Thayna Batalhoto Griggio, Charles M'poca Charles, Maria Julia de Oliveira Miele, Ricardo Porto Tedesco, Karayna Gil Fernandes, Sergio Hofmeister de Almeida Martins Costa, Frederico José Amedee Peret, Francisco Edson de Lucena Feitosa, Rosiane Mattar, Évelyn Traina, Edson Vieira da Cunha Filho, Janete Vettorazzi, Samira El Maerrawi Tebecherane Haddad, Carla Betina Andreucci Polido, José Paulo de Siqueira Guida, Mário Dias Corrêa Júnior, Marcos Augusto Bastos Dias, Leandro Gustavo de Oliveira, Elias Ferreira de Melo Junior, Carlos Augusto Santos de Menezes, Marília Gabriela Queiroz da Luz, Jose Guilherme Cecatti
• Format: Article
• Language: eng
• Source: Repositório Institucional da UFMG
• Download full: http://dx.doi.org/10.1136/bmjopen-2021-051284; http://hdl.handle.net/1843/55169; https://orcid.org/0000-0001-8280-3234; https://orcid.org/0000-0002-9075-9269; https://orcid.org/0000-0002-5739-0009; https://orcid.org/0000-0003-3048-2250; https://orcid.org/0000-0002-2630-9909; https://orcid.org/0000-0001-9863-9993; https://orcid.org/0000-0003-0268-3303; https://orcid.org/0000-0002-4376-8189; https://orcid.org/0000-0002-7356-8428; https://orcid.org/0000-0003-4335-0337; https://orcid.org/0000-0001-9406-4256; https://orcid.org/0000-0001-7133-0574; https://orcid.org/0000-0001-6270-6269; https://orcid.org/0000-0003-4851-6949; https://orcid.org/0000-0003-4014-6277; https://orcid.org/0000-0003-0565-9747; https://orcid.org/0000-0002-6975-6231; https://orcid.org/0000-0003-1405-5371; https://orcid.org/0000-0002-6856-8327; https://orcid.org/0000-0001-8100-1926; https://orcid.org/0000-0001-9278-6861; https://orcid.org/0000-0001-8352-8983; https://orcid.org/0000-0002-5590-108X; https://orcid.org/0000-0002-3648-6159; https://orcid.org/0000-0003-4198-0546; https://orcid.org/0000-0003-1386-7001; https://orcid.org/0000-0003-1285-8445
• topic: SARSCoV-2; COVID-19; Pregnancy; Postpartum; Maternity hospitals; COVID-19 (Doença); SARS-CoV-2; Maternidades; Gravidez; Período pós-parto

Introduction: The aim of this study was to evaluate the clinical, epidemiological and laboratory aspects of SARSCoV-2 infection during pregnancy and postpartum in 16 maternity hospitals. Methods and analysis: A prospective multicentre study, with five axes. First, the prevalence of SARS-CoV-2 infection among women admitted for childbirth will be described in a cross-sectional study. Second, maternal and perinatal outcomes will be assessed in a prospective cohort study including pregnant or postpartum women with suspected COVID-19. Third, a cohort of positive COVID-19 cases with sampling of a variety of biological material. Histopathological and viral analysis of biological maternal and neonatal samples will be performed, and the assessment of nutritional variables to evaluate the association between vitamin D and severity of infection. Fourth, a monitoring and evaluation committee to collect relevant healthcare information and plan actions in centres facing the pandemic. Furthermore, qualitative studies will be performed to study pregnant women, their families and health professionals. Fifth, an ecological study will monitor the number of live births, stillbirths and other outcomes to explore any trend among the periods before, during and after the pandemic. Data will systematically be collected in an electronic platform following standardised operational procedures. For quantitative study components, an appropriate statistical approach will be used for each analysis. For qualitative data, in-depth interviews recorded in audio will be transcribed, checking the text obtained with the recording. Subsequently, thematic analysis with the aid of the NVivo programme will be performed.