Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

• Autor(a) principal: Valery L. Feigin
• Data de Publicação: 2019
• Outros Autores: Richard G. Ellenbogen, Mate Car, Rosario Cárdenas, Juan J. Carrero, Félix Carvalho, Carlos A. Castañeda-Orjuela, Franz Castro, Ferrán Catalá-López, Ester Cerin, Yazan Chaiah, Lorenzo Giovanni Mantovani, Winfried März, Tivani Phosa Mashamba-Thompson, Benjamin Ballard Massenburg, Kedar K. V. Mate, Colm Mcalinden, John J. Mcgrath, Varshil Mehta, Lars Jacob Stovner, Vera M. Costa, Benoît Marin, Toni Meier, Hagazi Gebre Meles, Addisu Melese, Peter T. N. Memiah, Ziad A. Memish, Walter Mendoza, Desalegn Tadese Mengistu, Getnet Mengistu, Atte Meretoja, Tuomo J. Meretoja, Chi Linh Hoang, Michael H. Criqui, Cassandra E. I. Szoeke, Tomislav Mestrovic, Bartosz Miazgowski, Tomasz Miazgowski, Ted R. Miller, GK Mini, Erkin M. Mirrakhimov, Babak Moazen, Bahram Mohajer, Michael K. Hole, Naser Mohammad Gholi Mezerji, Christopher Stephen Crowe, Moslem Mohammadi, Alice Theadom, Maryam Mohammadi-Khanaposhtani, Roghayeh Mohammadibakhsh, Mousa Mohammadnia-Afrouzi, Shafiu Mohammed, Farnam Mohebi, Ali H. Mokdad, Enayatollah Homaie Rad, Lorenzo Monasta, Stefania Mondello, Albertino Antonio Moura Damasceno, Yoshan Moodley, Mahmood Moosazadeh, Tahiya Alam, Stein Emil Vollset, Ghobad Moradi, Maziar Moradi-Lakeh, Mehdi Moradinazar, Seyed Mostafa Hosseini, Paula Moraga, Ilais Moreno Velásquez, Shane Douglas Morrison, Christina Fitzmaurice, Seyyed Meysam Mousavi, Oumer Sada Muhammed, Walter Muruet, Kamarul Imran Musa, Mitchell Taylor Wallin, Ghulam Mustafa, Guoqing Hu, Mehdi Naderi, Gabriele Nagel, Aliya Naheed, Gurudatta Naik, Ahmad Daryani, Farid Najafi, Vinay Nangia, Ionut Negoi, Ruxandra Irina Negoi, Charles Richard James Newton, Ehimario U. Igumbor, Claire Wright, Josephine W. Ngunjiri, Cuong Tat Nguyen, Long Hoang Nguyen, Dina Nur Anggraini Ningrum, Vanessa De la Cruz-Góngora, Yirga Legesse Nirayo, Molly R. Nixon, Bo Norrving, Jean Jacques Noubiap, Olayinka Stephen Ilesanmi, Malihe Nourollahpour Shiadeh, Peter S. Nyasulu, Joseph Raymond Zunt, Okechukwu Samuel Ogah, In-hwan Oh, Andrew T. Olagunju, Fernando Pio De la Hoz, Tinuke O. Olagunju, Pedro R. Olivares, Obinna E. Onwujekwe, Seyed Sina Naghibi Irvani, Eyal Oren, Mayowa Ojo Owolabi, Mahesh PA, Amir H. Pakpour, Nooshin Abbasi, Wen-Harn Pan, Songhomitra Panda-Jonas, Diego De Leo, Jeyaraj Durai Pandian, Sangram Kishor Patel, Sheikh Mohammed Shariful Islam, David M. Pereira, Max Petzold, Julian David Pillay, Michael A. Piradov, Guilherme V. Polanczyk, Suzanne Polinder, Foad Abd-Allah, Maarten J. Postma, Gebre Teklemariam Demoz, Richie Poulton, Jung-Chen Chang, Hossein Poustchi, Swayam Prakash, V. Prakash, Mostafa Qorbani, Amir Radfar, Anwar Rafay, Alireza Rafiei, Fakher Rahim, Ahmed Abdelalim, Kebede Deribe, Mihajlo Jakovljevic, Vafa Rahimi-Movaghar, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, Muhammad Aziz Rahman, Fatemeh Rajati, Usha Ram, Anna Ranta, David Laith Rawaf, Salman Rawaf, Nickolas Reinig, Emma Nichols, Samath Dhamminda Dharmaratne, Ibrahim Abdollahpour, Cesar Reis, Andre M. N. Renzaho, Serge Resnikoff, Shahab Rezaeian, Mohammad Sadegh Rezai, Carlos Miguel Rios González, Nicholas L. S. Roberts, Leonardo Roever, W. Cliff Mountjoy-Venning, Luca Ronfani, Daniel Diaz, Elias Merdassa Roro, Victor Aboyans, Gholamreza Roshandel, Ali Rostami, Parisa Sabbagh, Ralph L. Sacco, Perminder S. Sachdev, Basema Saddik, Mehdi Javanbakht, Hosein Safari, Roya Safari-Faramani, Mesfin Tadese Dinberu, Sare Safi, Saeid Safiri, Haftom Niguse Abraha, Rajesh Sagar, Ramesh Sahathevan, Amirhossein Sahebkar, Mohammad Ali Sahraian, Ravi Prakash Jha, Payman Salamati, Saleh Salehi Zahabi, Yahya Salimi, Shirin Djalalinia, Abdallah M. Samy, Juan Sanabria, Itamar S. Santos, Marlena S. Bannick, Dilaram Acharya, Milena M. Santric Milicevic, Yash B. Jobanputra, Nizal Sarrafzadegan, Benn Sartorius, Shahabeddin Sarvi, Brijesh Sathian, Giorgia Giussani, Maheswar Satpathy, Arundhati R. Sawant, Monika Sawhney, Ione J. C. Schneider, Ben Schöttker, Jost B. Jonas, Abdu A. Adamu, David C. Schwebel, Soraya Seedat, Sadaf G. Sepanlou, Hosein Shabaninejad, David Teye Doku, Azadeh Shafieesabet, Masood Ali Shaikh, Raad A. Shakir, Mehran Shams-Beyranvand, Jacek Jerzy Jozwiak, Morteza Shamsizadeh, Mehdi Sharif, Oladimeji M. Adebayo, Mahdi Sharif-Alhoseini, Jun She, Aziz Sheikh, Manisha Dubey, Kevin N. Sheth, Mika Shigematsu, Rahman Shiri, Mikk Jürisson, Reza Shirkoohi, Ivy Shiue, Soraya Siabani, Tariq J. Siddiqi, Abiodun Moshood Adeoye, Inga Dora Sigfusdottir, Rannveig Sigurvinsdottir, Eleonora Dubljanin, Donald H. Silberberg, João Pedro Silva, Amaha Kahsay, Dayane Gabriele Alves Silveira, Jasvinder A. Singh, Dhirendra Narain Sinha, Eirini Skiadaresi, Mari Smith, Badr Hasan Sobaih, Jose C. Adsuar, Soheila Sobhani, Eyasu Ejeta Duken, Moslem Soofi, James L. Fisher, Ireneous N. Soyiri, Luciano A. Sposato, Dan J. Stein, Murray B. Stein, Mark A. Stokes, Mu'awiyyah Babale Sufiyan, Bryan L. Sykes, Pn Sylaja, Mohsen Afarideh, David Edvardsson, Rizwan Kalani, Rafael Tabarés-Seisdedos, Braden James Te Ao, Arash Tehrani-Banihashemi, Mohamad-Hani Temsah, Omar Temsah, Jarnail Singh Thakur, Amanda G. Thrift, Roman Topor-Madry, Miguel Tortajada-Girbés, Marcos Roberto Tovani-Palone, Yogeshwar Kalkonde, Ziad El-Khatib, Sutapa Agrawal, Bach Xuan Tran, Khanh Bao Tran, Thomas Clement Truelsen, Afewerki Gebremeskel Tsadik, Lorainne Tudor Car, Kingsley Nnanna Ukwaja, Irfan Ullah, Muhammad Shariq Usman, Teshome Abegaz Kamil, Olalekan A. Uthman, Matthias Endres, Pascual R. Valdez, Alireza Ahmadi, Tommi Juhani Vasankari, Rajagopalan Vasanthan, Yousef Veisani, Narayanaswamy Venketasubramanian, Francesco S. Violante, Vasily Vlassov, Minh Nguyen, Kia Vosoughi, Giang Thu Vu, Aman Yesuf Endries, Isidora S. Vujcic, Fasil Shiferaw Wagnew, Muktar Beshir Ahmed, Yasir Waheed, Yuan-Pang Wang, Elisabete Weiderpass, Jordan Weiss, Tanuj Kanchan, Harvey A. Whiteford, Tissa Wijeratne, Andrea Sylvia Winkler, Sharareh Eskandarieh, Charles Shey Wiysonge, Charles D. A. Wolfe, Gelin Xu, Amani Nidhal Aichour, Ali Yadollahpour, Tomohide Yamada, Manoochehr Karami, Yuichiro Yano, Mehdi Yaseri, Hiroshi Yatsuya, Ebrahim M. Yimer, Alireza Esteghamati, Paul Yip, Engida Yisma, Naohiro Yonemoto, Mahmoud Yousefifard, Ettore Beghi, André Karch, Ibtihel Aichour, Chuanhua yu, Zoubida Zaidi, Sojib Bin Zaman, Mohammad Zamani, Linda Glennie, Hamed Zandian, Zohreh Zare, Yunquan Zhang, Sanjay Zodpey, Narges Karimi, Mohsen Naghavi, Christopher J. L. Murray, Miloud Taki Eddine Aichour, Theo Vos, Rufus Olusola Akinyemi, Nadia Akseer, Sadaf Esteghamati, Ayman Al-Eyadhy, Rustam Al-Shahi Salman, Fares Alahdab, Amir Kasaeian, Kefyalew Addis Alene, Syed Mohamed Aljunid, Khalid Altirkawi, Natacha Blake, Nelson Alvis-Guzman, Nahla Hamed Anber, Carl Abelardo T. Antonio, Farzaneh Farhadi, Jalal Arabloo, Olatunde Aremu, Tesfaye Dessale Kassa, Johan Ärnlöv, Hamid Asayesh, Rana Jawad Asghar, Hagos Tasew Atalay, Ashish Awasthi, William J. Culpepper, Beatriz Paulina Ayala Quintanilla, Tambe B. Ayuk, Andre Faro, Alaa Badawi, Irini Chatziralli, Maciej Banach, Joseph Adel Mattar Banoub, Miguel A. Barboza, Suzanne Lyn Barker-Collo, Till Winfried Bärnighausen, Bernhard T. Baune, Neeraj Bedi, E. Ray Dorsey, Masoud Behzadifar, Farshad Farzadfar, Zemenu Yohannes Kassa, Meysam Behzadifar, Yannick Béjot, Bayu Begashaw Bekele, Abate Bekele Belachew, Derrick A. Bennett, Isabela M. Bensenor, Adugnaw Berhane, Mircea Beuran, Krittika Bhattacharyya, Alexis Elbaz, Anil Kaul, Mohammad Hosein Farzaei, Zulfiqar A. Bhutta, Belete Biadgo, Ali Bijani, Nigus Bililign, Muhammad Shahdaat Bin Sayeed, Christopher Kynrint Blazes, Carol Brayne, Zahid A. Butt, Ismael R. Campos-Nonato, Adane Teshome Kefale, Carlos Cantu-Brito, Batool Fatima, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Garumma Tolu Feyissa, Irina Filip, Spencer L. James, Florian Fischer, Takeshi Fukumoto, Morsaleh Ganji, Peter Njenga Keiyoro, Fortune Gbetoho Gankpe, Miguel A. Garcia-Gordillo, Abadi Kahsu Gebre, Teklu Gebrehiwo Gebremichael, Belayneh K. Gelaw, Johanna M. Geleijnse, Demeke Geremew, Catherine Owens Johnson, Kebede Embaye Gezae, Maryam Ghasemi-Kasman, Richard Ofori-Asenso, Mahari Y. Gidey, Paramjit Singh Gill, Tiffany K. Gill, Efrata Tufa Girma, Elena V. Gnedovskaya, Alessandra C. Goulart, Ayman Grada, Giuseppe Grosso, Nicholas J. Kassebaum, Yuming Guo, Yousef Saleh Khader, Rahul Gupta, Rajeev Gupta, Juanita A. Haagsma, Tekleberhan B. Hagos, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Randah R. Hamadeh, Samer Hamidi, Graeme J. Hankey, Giancarlo Logroscino, Morteza Abdullatif Khafaie, Yuantao Hao, Josep Maria Haro, Hadi Hassankhani, Hamid Yimam Hassen, Rasmus Havmoeller, Simon I. Hay, Mohamed I. Hegazy, Behnam Heidari, Andualem Henok, Fatemeh Heydarpour, Ibrahim A. Khalil, Ejaz Ahmad Khan, Young-Ho Khang, Peggy Pei-Chia Chiang, Habibolah Khazaie, Aliasghar A. Kiadaliri, Daniel N. Kiirithio, Anthony S. Kim, Daniel Kim, Anoop P. Patel, Young-Eun Kim, Yun Jin Kim, Adnan Kisa, Yoshihiro Kokubo, Hanne Christensen, Ai Koyanagi, Rita V. Krishnamurthi, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Manasi Kumar, Ben Lacey, Marco Piccininni, Alessandra Lafranconi, Van C. Lansingh, Arman Latifi, Devasahayam J. Christopher, Cheru Tesema Leshargie, Shanshan Li, Yu Liao, Shai Linn, Warren David Lo, Jaifred Christian F. Lopez, Stefan Lorkowski, Gregory A. Roth, Paulo A. Lotufo, Robyn M. Lucas, Cyrus Cooper, Raimundas Lunevicius, Mark T. Mackay, Narayan Bahadur Mahotra, Marek Majdan, Reza Majdzadeh, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Timothy J. Steiner, Navid Manafi, Paolo Angelo Cortesi, Mohammad Ali Mansournia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: http://dx.doi.org/10.1016/ S1474-4422(18)30499-X; http://hdl.handle.net/1843/51411; https://orcid.org/0000-0002-8214-5734
• topic: Nervous system diseases; Death; Cohort studies; Doenças do sistema nervoso; Morte; Estudos de coortes; Acidente vascular cerebral; Transtornos de enxaqueca; Doença de Alzheimer; Demência

Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders. Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer’s disease and other dementias, Parkinson’s disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their agestandardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer’s and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer’s disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable). Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies.