Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin.
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/1806 |
Resumo: | The scorpion envenoming syndrome is a serious public health matter in Brazil. The most severe cases occur during childhood and elderly. Previous results from our laboratory suggest that the effects of scorpion toxins on the central nervous system play a major role on the lethality induced by scorpion envenoming. The aim of this work is to evaluate the therapeutic potential of carbamazepine (CBZ) injected i.p. 90 min before s.c. tityustoxin (TsTX) injection in weanling rats. Rats were divided into six experimental groups according to s.c. injection (saline or TsTX) and i.p. treatment (vehicle or CBZ 12, 50 and 100 mg/kg): Sal/Veh group (n = 4); Sal/CBZ100 (n = 4); TsTX/CBZ12 (n = 6); TsTX/CBZ50 (n = 8); TsTX/CBZ100 (n = 8) and, at last, TsTX/Veh (n = 8). The dose of TsTX was the same for all groups: 6.0 mg/kg, twice the DL50 for weanling rats. Video images were recorded until death or for a maximum period of 240 min. Lungs were excised and weighed to evaluate edema. The results showed that CBZ (12, 50 and 100 mg/kg) was able to increase the survival rate and latency-to-death of the rats. Only the group treated with 100 mg/kg of CBZ had a decrease in the pulmonary edema. The known effect of CBZ reducing neuronal excitability most likely protected the neural substrates targeted by TsTX. Although treatment was performed before TsTX inoculation, the results are promising regarding CBZ as a therapeutic coadjuvant in the treatment of scorpion poisoning. The pharmacokinetics of CBZ can be very much improved by either changing the form of administration or encapsulating the drug in order to enhance solubility. |
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Guidine, Patrícia Alves MaiaAssumpção, GiocondaSantos, Tasso MoraesMassensini, André RicardoChianca Júnior, Deoclécio AlvesMoraes, Márcio Flávio Dutra2012-11-26T11:44:38Z2012-11-26T11:44:38Z2008GUIDINE, P. A. M. et al. Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin. Neuroscience Letters, v. 433, n. 3, p. 170-173, mar. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304394008000360>. Acesso em: 26 nov. 2012.03043940http://www.repositorio.ufop.br/handle/123456789/1806The scorpion envenoming syndrome is a serious public health matter in Brazil. The most severe cases occur during childhood and elderly. Previous results from our laboratory suggest that the effects of scorpion toxins on the central nervous system play a major role on the lethality induced by scorpion envenoming. The aim of this work is to evaluate the therapeutic potential of carbamazepine (CBZ) injected i.p. 90 min before s.c. tityustoxin (TsTX) injection in weanling rats. Rats were divided into six experimental groups according to s.c. injection (saline or TsTX) and i.p. treatment (vehicle or CBZ 12, 50 and 100 mg/kg): Sal/Veh group (n = 4); Sal/CBZ100 (n = 4); TsTX/CBZ12 (n = 6); TsTX/CBZ50 (n = 8); TsTX/CBZ100 (n = 8) and, at last, TsTX/Veh (n = 8). The dose of TsTX was the same for all groups: 6.0 mg/kg, twice the DL50 for weanling rats. Video images were recorded until death or for a maximum period of 240 min. Lungs were excised and weighed to evaluate edema. The results showed that CBZ (12, 50 and 100 mg/kg) was able to increase the survival rate and latency-to-death of the rats. Only the group treated with 100 mg/kg of CBZ had a decrease in the pulmonary edema. The known effect of CBZ reducing neuronal excitability most likely protected the neural substrates targeted by TsTX. Although treatment was performed before TsTX inoculation, the results are promising regarding CBZ as a therapeutic coadjuvant in the treatment of scorpion poisoning. The pharmacokinetics of CBZ can be very much improved by either changing the form of administration or encapsulating the drug in order to enhance solubility.CarbamazepineScorpion envenomingNeuroprotectionTityustoxinDose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleO periódico Neuroscience Letters concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3314370109997.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPORIGINALARTIGO_DoseDependentEffect.pdfARTIGO_DoseDependentEffect.pdfapplication/pdf207017http://www.repositorio.ufop.br/bitstream/123456789/1806/1/ARTIGO_DoseDependentEffect.pdf728811ae75f71015439e14a310625635MD51123456789/18062019-03-13 12:58:04.419oai:localhost:123456789/1806Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-03-13T16:58:04Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin. |
title |
Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin. |
spellingShingle |
Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin. Guidine, Patrícia Alves Maia Carbamazepine Scorpion envenoming Neuroprotection Tityustoxin |
title_short |
Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin. |
title_full |
Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin. |
title_fullStr |
Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin. |
title_full_unstemmed |
Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin. |
title_sort |
Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin. |
author |
Guidine, Patrícia Alves Maia |
author_facet |
Guidine, Patrícia Alves Maia Assumpção, Gioconda Santos, Tasso Moraes Massensini, André Ricardo Chianca Júnior, Deoclécio Alves Moraes, Márcio Flávio Dutra |
author_role |
author |
author2 |
Assumpção, Gioconda Santos, Tasso Moraes Massensini, André Ricardo Chianca Júnior, Deoclécio Alves Moraes, Márcio Flávio Dutra |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Guidine, Patrícia Alves Maia Assumpção, Gioconda Santos, Tasso Moraes Massensini, André Ricardo Chianca Júnior, Deoclécio Alves Moraes, Márcio Flávio Dutra |
dc.subject.por.fl_str_mv |
Carbamazepine Scorpion envenoming Neuroprotection Tityustoxin |
topic |
Carbamazepine Scorpion envenoming Neuroprotection Tityustoxin |
description |
The scorpion envenoming syndrome is a serious public health matter in Brazil. The most severe cases occur during childhood and elderly. Previous results from our laboratory suggest that the effects of scorpion toxins on the central nervous system play a major role on the lethality induced by scorpion envenoming. The aim of this work is to evaluate the therapeutic potential of carbamazepine (CBZ) injected i.p. 90 min before s.c. tityustoxin (TsTX) injection in weanling rats. Rats were divided into six experimental groups according to s.c. injection (saline or TsTX) and i.p. treatment (vehicle or CBZ 12, 50 and 100 mg/kg): Sal/Veh group (n = 4); Sal/CBZ100 (n = 4); TsTX/CBZ12 (n = 6); TsTX/CBZ50 (n = 8); TsTX/CBZ100 (n = 8) and, at last, TsTX/Veh (n = 8). The dose of TsTX was the same for all groups: 6.0 mg/kg, twice the DL50 for weanling rats. Video images were recorded until death or for a maximum period of 240 min. Lungs were excised and weighed to evaluate edema. The results showed that CBZ (12, 50 and 100 mg/kg) was able to increase the survival rate and latency-to-death of the rats. Only the group treated with 100 mg/kg of CBZ had a decrease in the pulmonary edema. The known effect of CBZ reducing neuronal excitability most likely protected the neural substrates targeted by TsTX. Although treatment was performed before TsTX inoculation, the results are promising regarding CBZ as a therapeutic coadjuvant in the treatment of scorpion poisoning. The pharmacokinetics of CBZ can be very much improved by either changing the form of administration or encapsulating the drug in order to enhance solubility. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2012-11-26T11:44:38Z |
dc.date.available.fl_str_mv |
2012-11-26T11:44:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GUIDINE, P. A. M. et al. Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin. Neuroscience Letters, v. 433, n. 3, p. 170-173, mar. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304394008000360>. Acesso em: 26 nov. 2012. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/1806 |
dc.identifier.issn.none.fl_str_mv |
03043940 |
identifier_str_mv |
GUIDINE, P. A. M. et al. Dose-dependent effect of carbamazepine on weanling rats submitted to subcutaneous injection of tityustoxin. Neuroscience Letters, v. 433, n. 3, p. 170-173, mar. 2008. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0304394008000360>. Acesso em: 26 nov. 2012. 03043940 |
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http://www.repositorio.ufop.br/handle/123456789/1806 |
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eng |
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