Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects.
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/9035 https://www.karger.com/Article/Abstract/448101 https://doi.org/10.1159/000448101 |
Resumo: | Background/Aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. Methods: Forty normal-weight young women were involved in this crosssectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005). Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = –0.460, p = 0.003) and TNF-α total methylation (r = –0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-α methylation. No other dietary pattern was related to TNF-α methylation. TNF-α total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = –0.324, p = 0.041) and TNF-α total methylation (r = –0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-α total methylation (r = –0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-α total methylation. Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-α methylation. |
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Carraro, Júlia Cristina CardosoHermsdorff, Helen Hermana MirandaMansego, Maria LuisaZulet, Maria AngelesMilagro, Fermín IgnacioBressan, JosefinaMartínez, J. Alfredo2017-10-24T17:20:27Z2017-10-24T17:20:27Z2016CARRARO, J. C. C. et al. Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. Journal of Nutrigenetics and Nutrigenomics, v. 9, p. 95-105, 2016. Disponível em: <https://www.karger.com/Article/Abstract/448101>. Acesso em: 29 ago. 2017.1661-6758http://www.repositorio.ufop.br/handle/123456789/9035https://www.karger.com/Article/Abstract/448101https://doi.org/10.1159/000448101Background/Aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. Methods: Forty normal-weight young women were involved in this crosssectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005). Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = –0.460, p = 0.003) and TNF-α total methylation (r = –0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-α methylation. No other dietary pattern was related to TNF-α methylation. TNF-α total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = –0.324, p = 0.041) and TNF-α total methylation (r = –0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-α total methylation (r = –0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-α total methylation. Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-α methylation.BiomarkerInflammationEpigeneticsDNA methylationDietHigher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/9035/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_HigherFruitIntakes.pdfARTIGO_HigherFruitIntakes.pdfapplication/pdf596729http://www.repositorio.ufop.br/bitstream/123456789/9035/1/ARTIGO_HigherFruitIntakes.pdf5744e654e9652b1226df3c58b93e7fb0MD51123456789/90352020-02-17 10:02:18.096oai:localhost:123456789/9035RGVjbGFyYcOnw6NvIGRlIGRpc3RyaWJ1acOnw6NvIG7Do28tZXhjbHVzaXZhCgpPIHJlZmVyaWRvIGF1dG9yOgoKYSlEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBlbnRyZWd1ZSDDqSBzZXUgdHJhYmFsaG8gb3JpZ2luYWwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBvcyBkaXJlaXRvcyBjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gRGVjbGFyYSB0YW1iw6ltIHF1ZSBhIGVudHJlZ2EgZG8gZG9jdW1lbnRvIG7Do28gaW5mcmluZ2UsIHRhbnRvIHF1YW50byBsaGUgw6kgcG9zc8OtdmVsIHNhYmVyLCBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBwZXNzb2Egb3UgZW50aWRhZGUuCgpiKVNlIG8gZG9jdW1lbnRvIGVudHJlZ3VlIGNvbnTDqW0gbWF0ZXJpYWwgZG8gcXVhbCBuw6NvIGRldMOpbSBvcyBkaXJlaXRvcyBkZSBhdXRvciwgZGVjbGFyYSBxdWUgb2J0ZXZlIGF1dG9yaXphw6fDo28gZG8gZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGRlIGF1dG9yIHBhcmEgY29uY2VkZXIgw6AgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZGUgT3VybyBQcmV0by9VRk9QIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgbGljZW7Dp2EgZSBxdWUgZXNzZSBtYXRlcmlhbCwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MsIGVzdMOhIGNsYXJhbWVudGUgaWRlbnRpZmljYWRvIGUgcmVjb25oZWNpZG8gbm8gdGV4dG8gb3UgY29udGXDumRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpjKVNlIG8gZG9jdW1lbnRvIGVudHJlZ3VlIMOpIGJhc2VhZG8gZW0gdHJhYmFsaG8gZmluYW5jaWFkbyBvdSBhcG9pYWRvIHBvciBvdXRyYSBpbnN0aXR1acOnw6NvIHF1ZSBuw6NvIGEgVUZPUCwgZGVjbGFyYSBxdWUgY3VtcHJpdSBxdWFpc3F1ZXIgb2JyaWdhw6fDtWVzIGV4aWdpZGFzIHBlbG8gY29udHJhdG8gb3UgYWNvcmRvLgoKRepositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332020-02-17T15:02:18Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. |
title |
Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. |
spellingShingle |
Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. Carraro, Júlia Cristina Cardoso Biomarker Inflammation Epigenetics DNA methylation Diet |
title_short |
Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. |
title_full |
Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. |
title_fullStr |
Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. |
title_full_unstemmed |
Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. |
title_sort |
Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. |
author |
Carraro, Júlia Cristina Cardoso |
author_facet |
Carraro, Júlia Cristina Cardoso Hermsdorff, Helen Hermana Miranda Mansego, Maria Luisa Zulet, Maria Angeles Milagro, Fermín Ignacio Bressan, Josefina Martínez, J. Alfredo |
author_role |
author |
author2 |
Hermsdorff, Helen Hermana Miranda Mansego, Maria Luisa Zulet, Maria Angeles Milagro, Fermín Ignacio Bressan, Josefina Martínez, J. Alfredo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Carraro, Júlia Cristina Cardoso Hermsdorff, Helen Hermana Miranda Mansego, Maria Luisa Zulet, Maria Angeles Milagro, Fermín Ignacio Bressan, Josefina Martínez, J. Alfredo |
dc.subject.por.fl_str_mv |
Biomarker Inflammation Epigenetics DNA methylation Diet |
topic |
Biomarker Inflammation Epigenetics DNA methylation Diet |
description |
Background/Aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. Methods: Forty normal-weight young women were involved in this crosssectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005). Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = –0.460, p = 0.003) and TNF-α total methylation (r = –0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-α methylation. No other dietary pattern was related to TNF-α methylation. TNF-α total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = –0.324, p = 0.041) and TNF-α total methylation (r = –0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-α total methylation (r = –0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-α total methylation. Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-α methylation. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2017-10-24T17:20:27Z |
dc.date.available.fl_str_mv |
2017-10-24T17:20:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARRARO, J. C. C. et al. Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. Journal of Nutrigenetics and Nutrigenomics, v. 9, p. 95-105, 2016. Disponível em: <https://www.karger.com/Article/Abstract/448101>. Acesso em: 29 ago. 2017. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/9035 |
dc.identifier.issn.none.fl_str_mv |
1661-6758 |
dc.identifier.uri2.pt_BR.fl_str_mv |
https://www.karger.com/Article/Abstract/448101 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1159/000448101 |
identifier_str_mv |
CARRARO, J. C. C. et al. Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects. Journal of Nutrigenetics and Nutrigenomics, v. 9, p. 95-105, 2016. Disponível em: <https://www.karger.com/Article/Abstract/448101>. Acesso em: 29 ago. 2017. 1661-6758 |
url |
http://www.repositorio.ufop.br/handle/123456789/9035 https://www.karger.com/Article/Abstract/448101 https://doi.org/10.1159/000448101 |
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eng |
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eng |
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openAccess |
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