Salacia crassifolia (Celastraceae) : chemical constituents and antimicrobial activity.

• Autor(a) principal: Rodrigues, Vanessa Gregório
• Data de Publicação: 2015
• Outros Autores: Duarte, Lucienir Pains, Silva, Roqueline Rodrigues, Silva, Grácia Divina de Fátima, Simões, Maria O. Mercadante, Takahashi, Jacqueline Aparecida, Matildes, Bibiane Lindsay Guimarães, Fonseca, Thaisa Helena Silva, Gomes, Maria Aparecida, Vieira Filho, Sidney Augusto
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/handle/123456789/6008; http://dx.doi.org/10.5935/0100-4042.20150001

The phytochemical study of hexane extract from leaves of Salacia crassifolia resulted in the isolation of 3β-palmitoxy-urs-12-ene, 3-oxofriedelane, 3β-hydroxyfriedelane, 3-oxo-28-hydroxyfriedelane, 3-oxo-29-hydroxyfriedelane, 28,29-dihydroxyfriedelan-3-one, 3,4-seco-friedelan-3-oic acid, 3β-hydroxy-olean-9(11):12-diene and the mixture of α-amirin and β-amirin. β-sitosterol, the polymer gutta-percha, squalene and eicosanoic acid were also isolated. The chemical structures of these constituents were established by IR, 1H and 13C NMR spectral data. Crude extracts and the triterpenes were tested against Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis and no activity was observed under the in vitro assay conditions. The hexane, chloroform, ethyl acetate and ethanol crude extracts, and the constituent 3,4-seco-friedelan-3-oic acid and 28,29-dihydroxyfriedelan-3-one showed in vitro antimicrobial activity against Salmonella typhimurium, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Streptococcus sanguinis and Candida albicans.