Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet.
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/11114 |
Resumo: | Bioactive compounds, present in some foods, act enhancing the endogenous antioxidant system and are proposed as an effective strategy in preventing the changes induced by free radicals in some diseases, such as nonalcoholic fatty liver disease (NAFLD). There has been an increase in the number of studies carried out with the aim of finding natural antioxidant compounds present in fruits, mainly the native fruits of Brazil, because they contain a high content of these compounds. Araçá (Psidium cattleianum Sabine) is a fruit that is rich in polyphenols and exhibits strong antioxidant, antiproliferative, and anti-inflammatory activities. Therefore, the present study investigated the effects of araçá flour on oxidative stress, liver injury, and antioxidant defenses in high-fat diet-induced hepatic steatosis in rats. In vitro experiments showed that araçá contains high concentrations of total polyphenols and exhibits strong antioxidant activity with no cytotoxicity. In vivo experiments indicated that the addition of araçá to a high-fat diet inhibited the activities of alanine aminotransferase and aspartate enzymes, reduced macrovesicular steatosis, increased the paraoxonase activity, and increased the concentration of the total and reduced forms of glutathione. Therefore, our findings suggested the hepatoprotective role of araçá against the progression of steatosis. |
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Paulino, Alice Helena de SouzaViana, Ana Maria FernandesBonomo, Larissa de FreitasGuerra, Joyce Ferreira da CostaLopes, Juliana Márcia MacedoRabelo, Ana Carolina SilveiraFagundes, Miliane Martins de AndradeRegis, Ana Lúcia Rissoni dos SantosLima, Wanderson Geraldo dePedrosa, Maria LúciaSilva, Marcelo Eustáquio2019-04-24T14:41:58Z2019-04-24T14:41:58Z2019PAULINO, A. H. de S. et al. Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet. Journal of Food and Nutrition Research, v. 7, n. 2, p. 132-140, 2019. Disponível em: <http://www.sciepub.com/JFNR/abstract/10154>. Acesso em: 7 mar. 2019.2333-1240http://www.repositorio.ufop.br/handle/123456789/11114Bioactive compounds, present in some foods, act enhancing the endogenous antioxidant system and are proposed as an effective strategy in preventing the changes induced by free radicals in some diseases, such as nonalcoholic fatty liver disease (NAFLD). There has been an increase in the number of studies carried out with the aim of finding natural antioxidant compounds present in fruits, mainly the native fruits of Brazil, because they contain a high content of these compounds. Araçá (Psidium cattleianum Sabine) is a fruit that is rich in polyphenols and exhibits strong antioxidant, antiproliferative, and anti-inflammatory activities. Therefore, the present study investigated the effects of araçá flour on oxidative stress, liver injury, and antioxidant defenses in high-fat diet-induced hepatic steatosis in rats. In vitro experiments showed that araçá contains high concentrations of total polyphenols and exhibits strong antioxidant activity with no cytotoxicity. In vivo experiments indicated that the addition of araçá to a high-fat diet inhibited the activities of alanine aminotransferase and aspartate enzymes, reduced macrovesicular steatosis, increased the paraoxonase activity, and increased the concentration of the total and reduced forms of glutathione. Therefore, our findings suggested the hepatoprotective role of araçá against the progression of steatosis.This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Fonte: o próprio artigo.info:eu-repo/semantics/openAccessPhenolic compoundsAntioxidants defensesAraçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/11114/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_AraçáPsidiumCattleianum.pdfARTIGO_AraçáPsidiumCattleianum.pdfapplication/pdf565225http://www.repositorio.ufop.br/bitstream/123456789/11114/1/ARTIGO_Ara%c3%a7%c3%a1PsidiumCattleianum.pdfeb298df9b399d559893b55aa1f14d0fcMD51123456789/111142019-04-24 10:41:58.751oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-04-24T14:41:58Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet. |
title |
Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet. |
spellingShingle |
Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet. Paulino, Alice Helena de Souza Phenolic compounds Antioxidants defenses |
title_short |
Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet. |
title_full |
Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet. |
title_fullStr |
Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet. |
title_full_unstemmed |
Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet. |
title_sort |
Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet. |
author |
Paulino, Alice Helena de Souza |
author_facet |
Paulino, Alice Helena de Souza Viana, Ana Maria Fernandes Bonomo, Larissa de Freitas Guerra, Joyce Ferreira da Costa Lopes, Juliana Márcia Macedo Rabelo, Ana Carolina Silveira Fagundes, Miliane Martins de Andrade Regis, Ana Lúcia Rissoni dos Santos Lima, Wanderson Geraldo de Pedrosa, Maria Lúcia Silva, Marcelo Eustáquio |
author_role |
author |
author2 |
Viana, Ana Maria Fernandes Bonomo, Larissa de Freitas Guerra, Joyce Ferreira da Costa Lopes, Juliana Márcia Macedo Rabelo, Ana Carolina Silveira Fagundes, Miliane Martins de Andrade Regis, Ana Lúcia Rissoni dos Santos Lima, Wanderson Geraldo de Pedrosa, Maria Lúcia Silva, Marcelo Eustáquio |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Paulino, Alice Helena de Souza Viana, Ana Maria Fernandes Bonomo, Larissa de Freitas Guerra, Joyce Ferreira da Costa Lopes, Juliana Márcia Macedo Rabelo, Ana Carolina Silveira Fagundes, Miliane Martins de Andrade Regis, Ana Lúcia Rissoni dos Santos Lima, Wanderson Geraldo de Pedrosa, Maria Lúcia Silva, Marcelo Eustáquio |
dc.subject.por.fl_str_mv |
Phenolic compounds Antioxidants defenses |
topic |
Phenolic compounds Antioxidants defenses |
description |
Bioactive compounds, present in some foods, act enhancing the endogenous antioxidant system and are proposed as an effective strategy in preventing the changes induced by free radicals in some diseases, such as nonalcoholic fatty liver disease (NAFLD). There has been an increase in the number of studies carried out with the aim of finding natural antioxidant compounds present in fruits, mainly the native fruits of Brazil, because they contain a high content of these compounds. Araçá (Psidium cattleianum Sabine) is a fruit that is rich in polyphenols and exhibits strong antioxidant, antiproliferative, and anti-inflammatory activities. Therefore, the present study investigated the effects of araçá flour on oxidative stress, liver injury, and antioxidant defenses in high-fat diet-induced hepatic steatosis in rats. In vitro experiments showed that araçá contains high concentrations of total polyphenols and exhibits strong antioxidant activity with no cytotoxicity. In vivo experiments indicated that the addition of araçá to a high-fat diet inhibited the activities of alanine aminotransferase and aspartate enzymes, reduced macrovesicular steatosis, increased the paraoxonase activity, and increased the concentration of the total and reduced forms of glutathione. Therefore, our findings suggested the hepatoprotective role of araçá against the progression of steatosis. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-04-24T14:41:58Z |
dc.date.available.fl_str_mv |
2019-04-24T14:41:58Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PAULINO, A. H. de S. et al. Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet. Journal of Food and Nutrition Research, v. 7, n. 2, p. 132-140, 2019. Disponível em: <http://www.sciepub.com/JFNR/abstract/10154>. Acesso em: 7 mar. 2019. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/11114 |
dc.identifier.issn.none.fl_str_mv |
2333-1240 |
identifier_str_mv |
PAULINO, A. H. de S. et al. Araçá (Psidium cattleianum Sabine) ameliorates liver damage and reduces hepatic steatosis in rats fed with a high-fat diet. Journal of Food and Nutrition Research, v. 7, n. 2, p. 132-140, 2019. Disponível em: <http://www.sciepub.com/JFNR/abstract/10154>. Acesso em: 7 mar. 2019. 2333-1240 |
url |
http://www.repositorio.ufop.br/handle/123456789/11114 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
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UFOP |
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UFOP |
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Repositório Institucional da UFOP |
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Repositório Institucional da UFOP |
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