Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis.
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/1043 |
Resumo: | We have performed a detailed investigation in 40 dogs naturally infected withLeishmania infantum ( syn. chagasi), subdivided into three groups: asymptomatic (AD = 12), oligosymptomatic (OD = 12) and symptomatic (SD = 16), based on their clinical features. Twenty non-infected dogs (CD) were included as control group. Serological analysis, performed by IFAT and ELISA, demonstrated higher antibodies titers in SD in comparison to the AD. A positive correlation was found between parasite density in the spleen and skin smears as well as the bone marrow parasitism with clinical status of the infection. We observed that the progression of the disease from asymptomatic to symptomatic clinical form was accompanied by intense parasitism in the bone marrow. It is likely that this led to the impaired biochemical/hematological status observed. Finally, we believe that the follow-up of these parameters could be a relevant approach to be used as markers during therapeutic and vaccine evaluations. |
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Reis, Alexandre BarbosaMartins Filho, Olindo AssisCarvalho, Andréa Teixeira deCarvalho, Maria das GraçasMayrink, WilsonSilva, João Carlos França daGiunchetti, Rodolfo CordeiroGenaro, OdairOliveira, Rodrigo Corrêa de2012-07-10T14:57:59Z2012-07-10T14:57:59Z2006REIS, A. B. et al. Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. Research in veterinary Science, v. 81, n. 1, p. 68-75, ago. 2006. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0034528805001748>. Acesso em: 10 jul. 2012.00345288http://www.repositorio.ufop.br/handle/123456789/1043We have performed a detailed investigation in 40 dogs naturally infected withLeishmania infantum ( syn. chagasi), subdivided into three groups: asymptomatic (AD = 12), oligosymptomatic (OD = 12) and symptomatic (SD = 16), based on their clinical features. Twenty non-infected dogs (CD) were included as control group. Serological analysis, performed by IFAT and ELISA, demonstrated higher antibodies titers in SD in comparison to the AD. A positive correlation was found between parasite density in the spleen and skin smears as well as the bone marrow parasitism with clinical status of the infection. We observed that the progression of the disease from asymptomatic to symptomatic clinical form was accompanied by intense parasitism in the bone marrow. It is likely that this led to the impaired biochemical/hematological status observed. Finally, we believe that the follow-up of these parameters could be a relevant approach to be used as markers during therapeutic and vaccine evaluations.Canine visceral leishmaniasisLeishmania infantumParasite densityBiochemical/hematological statusParasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleO periódico Research in Veterinary Science concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3291410100627.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://www.repositorio.ufop.br/bitstream/123456789/1043/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-820325http://www.repositorio.ufop.br/bitstream/123456789/1043/4/license_rdfc7f3e3c064c19e93e905bbb07856484cMD54ORIGINALARTIGO_ParasiteDensityImpaired.pdfARTIGO_ParasiteDensityImpaired.pdfapplication/pdf252951http://www.repositorio.ufop.br/bitstream/123456789/1043/1/ARTIGO_ParasiteDensityImpaired.pdf996e8ab8ae72021ed3a5d8a2ef4ecabfMD51123456789/10432019-02-25 13:13:15.949oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-02-25T18:13:15Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. |
title |
Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. |
spellingShingle |
Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. Reis, Alexandre Barbosa Canine visceral leishmaniasis Leishmania infantum Parasite density Biochemical/hematological status |
title_short |
Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. |
title_full |
Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. |
title_fullStr |
Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. |
title_full_unstemmed |
Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. |
title_sort |
Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. |
author |
Reis, Alexandre Barbosa |
author_facet |
Reis, Alexandre Barbosa Martins Filho, Olindo Assis Carvalho, Andréa Teixeira de Carvalho, Maria das Graças Mayrink, Wilson Silva, João Carlos França da Giunchetti, Rodolfo Cordeiro Genaro, Odair Oliveira, Rodrigo Corrêa de |
author_role |
author |
author2 |
Martins Filho, Olindo Assis Carvalho, Andréa Teixeira de Carvalho, Maria das Graças Mayrink, Wilson Silva, João Carlos França da Giunchetti, Rodolfo Cordeiro Genaro, Odair Oliveira, Rodrigo Corrêa de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Reis, Alexandre Barbosa Martins Filho, Olindo Assis Carvalho, Andréa Teixeira de Carvalho, Maria das Graças Mayrink, Wilson Silva, João Carlos França da Giunchetti, Rodolfo Cordeiro Genaro, Odair Oliveira, Rodrigo Corrêa de |
dc.subject.por.fl_str_mv |
Canine visceral leishmaniasis Leishmania infantum Parasite density Biochemical/hematological status |
topic |
Canine visceral leishmaniasis Leishmania infantum Parasite density Biochemical/hematological status |
description |
We have performed a detailed investigation in 40 dogs naturally infected withLeishmania infantum ( syn. chagasi), subdivided into three groups: asymptomatic (AD = 12), oligosymptomatic (OD = 12) and symptomatic (SD = 16), based on their clinical features. Twenty non-infected dogs (CD) were included as control group. Serological analysis, performed by IFAT and ELISA, demonstrated higher antibodies titers in SD in comparison to the AD. A positive correlation was found between parasite density in the spleen and skin smears as well as the bone marrow parasitism with clinical status of the infection. We observed that the progression of the disease from asymptomatic to symptomatic clinical form was accompanied by intense parasitism in the bone marrow. It is likely that this led to the impaired biochemical/hematological status observed. Finally, we believe that the follow-up of these parameters could be a relevant approach to be used as markers during therapeutic and vaccine evaluations. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
dc.date.accessioned.fl_str_mv |
2012-07-10T14:57:59Z |
dc.date.available.fl_str_mv |
2012-07-10T14:57:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
REIS, A. B. et al. Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. Research in veterinary Science, v. 81, n. 1, p. 68-75, ago. 2006. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0034528805001748>. Acesso em: 10 jul. 2012. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/1043 |
dc.identifier.issn.none.fl_str_mv |
00345288 |
identifier_str_mv |
REIS, A. B. et al. Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. Research in veterinary Science, v. 81, n. 1, p. 68-75, ago. 2006. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0034528805001748>. Acesso em: 10 jul. 2012. 00345288 |
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http://www.repositorio.ufop.br/handle/123456789/1043 |
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