Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.

Detalhes bibliográficos
Autor(a) principal: Assis, Danielle Nogueira de
Data de Publicação: 2018
Outros Autores: Araújo, Raquel Silva, Fuscaldi, Leonardo Lima, Diniz, Simone Odília Antunes Fernandes, Mosqueira, Vanessa Carla Furtado, Cardoso, Valbert Nascimento
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/9940
https://www.sciencedirect.com/science/article/pii/S0753332217351478
Resumo: Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99mTc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection.
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spelling Assis, Danielle Nogueira deAraújo, Raquel SilvaFuscaldi, Leonardo LimaDiniz, Simone Odília Antunes FernandesMosqueira, Vanessa Carla FurtadoCardoso, Valbert Nascimento2018-05-15T14:12:04Z2018-05-15T14:12:04Z2018ASSIS, D. N. de et al. Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. Biomedicine & Pharmacotherapy, v. 99, p. 438-444, 2018. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332217351478>. Acesso em: 05 abr. 2018. 07533322http://www.repositorio.ufop.br/handle/123456789/9940https://www.sciencedirect.com/science/article/pii/S0753332217351478Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99mTc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection.Candida sppFluconazoleBiodistributionNanocapsulesBiodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/9940/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_BiodistributionFreeEncapsulated.pdfARTIGO_BiodistributionFreeEncapsulated.pdfapplication/pdf579515http://www.repositorio.ufop.br/bitstream/123456789/9940/1/ARTIGO_BiodistributionFreeEncapsulated.pdfee2f1062c70da69f6b9f7114ca654897MD51123456789/99402018-05-15 10:12:04.533oai:localhost:123456789/9940RGVjbGFyYcOnw6NvIGRlIGRpc3RyaWJ1acOnw6NvIG7Do28tZXhjbHVzaXZhCgpPIHJlZmVyaWRvIGF1dG9yOgoKYSlEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBlbnRyZWd1ZSDDqSBzZXUgdHJhYmFsaG8gb3JpZ2luYWwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBvcyBkaXJlaXRvcyBjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gRGVjbGFyYSB0YW1iw6ltIHF1ZSBhIGVudHJlZ2EgZG8gZG9jdW1lbnRvIG7Do28gaW5mcmluZ2UsIHRhbnRvIHF1YW50byBsaGUgw6kgcG9zc8OtdmVsIHNhYmVyLCBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBwZXNzb2Egb3UgZW50aWRhZGUuCgpiKVNlIG8gZG9jdW1lbnRvIGVudHJlZ3VlIGNvbnTDqW0gbWF0ZXJpYWwgZG8gcXVhbCBuw6NvIGRldMOpbSBvcyBkaXJlaXRvcyBkZSBhdXRvciwgZGVjbGFyYSBxdWUgb2J0ZXZlIGF1dG9yaXphw6fDo28gZG8gZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGRlIGF1dG9yIHBhcmEgY29uY2VkZXIgw6AgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZGUgT3VybyBQcmV0by9VRk9QIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgbGljZW7Dp2EgZSBxdWUgZXNzZSBtYXRlcmlhbCwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MsIGVzdMOhIGNsYXJhbWVudGUgaWRlbnRpZmljYWRvIGUgcmVjb25oZWNpZG8gbm8gdGV4dG8gb3UgY29udGXDumRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpjKVNlIG8gZG9jdW1lbnRvIGVudHJlZ3VlIMOpIGJhc2VhZG8gZW0gdHJhYmFsaG8gZmluYW5jaWFkbyBvdSBhcG9pYWRvIHBvciBvdXRyYSBpbnN0aXR1acOnw6NvIHF1ZSBuw6NvIGEgVUZPUCwgZGVjbGFyYSBxdWUgY3VtcHJpdSBxdWFpc3F1ZXIgb2JyaWdhw6fDtWVzIGV4aWdpZGFzIHBlbG8gY29udHJhdG8gb3UgYWNvcmRvLgoKRepositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332018-05-15T14:12:04Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.pt_BR.fl_str_mv Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.
title Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.
spellingShingle Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.
Assis, Danielle Nogueira de
Candida spp
Fluconazole
Biodistribution
Nanocapsules
title_short Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.
title_full Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.
title_fullStr Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.
title_full_unstemmed Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.
title_sort Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans.
author Assis, Danielle Nogueira de
author_facet Assis, Danielle Nogueira de
Araújo, Raquel Silva
Fuscaldi, Leonardo Lima
Diniz, Simone Odília Antunes Fernandes
Mosqueira, Vanessa Carla Furtado
Cardoso, Valbert Nascimento
author_role author
author2 Araújo, Raquel Silva
Fuscaldi, Leonardo Lima
Diniz, Simone Odília Antunes Fernandes
Mosqueira, Vanessa Carla Furtado
Cardoso, Valbert Nascimento
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Assis, Danielle Nogueira de
Araújo, Raquel Silva
Fuscaldi, Leonardo Lima
Diniz, Simone Odília Antunes Fernandes
Mosqueira, Vanessa Carla Furtado
Cardoso, Valbert Nascimento
dc.subject.por.fl_str_mv Candida spp
Fluconazole
Biodistribution
Nanocapsules
topic Candida spp
Fluconazole
Biodistribution
Nanocapsules
description Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99mTc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-05-15T14:12:04Z
dc.date.available.fl_str_mv 2018-05-15T14:12:04Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ASSIS, D. N. de et al. Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. Biomedicine & Pharmacotherapy, v. 99, p. 438-444, 2018. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332217351478>. Acesso em: 05 abr. 2018.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufop.br/handle/123456789/9940
dc.identifier.issn.none.fl_str_mv  07533322
dc.identifier.uri2.pt_BR.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0753332217351478
identifier_str_mv ASSIS, D. N. de et al. Biodistribution of free and encapsulated 99mTc-fluconazole in an infection model induced by Candida albicans. Biomedicine & Pharmacotherapy, v. 99, p. 438-444, 2018. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0753332217351478>. Acesso em: 05 abr. 2018.
 07533322
url http://www.repositorio.ufop.br/handle/123456789/9940
https://www.sciencedirect.com/science/article/pii/S0753332217351478
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
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institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
bitstream.url.fl_str_mv http://www.repositorio.ufop.br/bitstream/123456789/9940/2/license.txt
http://www.repositorio.ufop.br/bitstream/123456789/9940/1/ARTIGO_BiodistributionFreeEncapsulated.pdf
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repository.mail.fl_str_mv repositorio@ufop.edu.br
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