A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study.
Main Author: | |
---|---|
Publication Date: | 2010 |
Other Authors: | , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UFOP |
Download full: | http://www.repositorio.ufop.br/handle/123456789/7715 https://doi.org/10.1017/S0007114510001145 |
Summary: | The objective of the present study was to investigate the influence of the single nucleotide polymorphism (rs17238540) at the 3-hydroxy-3-methylglutaryl- coenzyme A reductase gene (HMGCR) on the relationship between serum lipids and dietary fat and fibre (NSP). FFQ and pyrosequencing were used to assess cross-sectional dietary intake and HMGCR genotype in a population study with data for serum lipids available. Genotype frequencies and allele distributions for 23 011 participants were: TT 95·65 %, TG 4·29% and GG 0·06 %; T 97·8% and G 2·2 %. In regression analyses, the TG þ GG group showed a significant positive relationship between TAG and SFA intake (þ0·11 (95% CI 0·02, 0·20) mmol TAG/l; P¼0·017; per 3% SFA energy increase) while the TT individuals showed no change in the TAG levels related to SFA intake (20·0007 (95% CI 20·02, 0·02) mmol TAG/l; P¼0·99). TG þ GG individuals showed an inverse relationship between TAG and fibre intake higher (20·14 (95% CI 20·22, 20·05) mmol TAG/l than the TT group (20·04 (95% CI 20·06, 20·02) mmol TAG/l). In both cases the respective coefficient regressions of TAG were different between the genotype groups (Z ¼ 2·27, P¼0·023 for SFA intake; Z ¼ 2·19, P¼0·029 for fibre intake). Individuals carrying the G allele may show a greater response in lower TAG levels with reduced SFA intake and increased fibre intake compared with those homozygous for the T allele. The effectiveness of different dietary interventions to control serum lipids may vary according to HMGCR genotype. |
id |
UFOP_e7e8eb10d3965590978120cc40908f4a |
---|---|
oai_identifier_str |
oai:localhost:123456789/7715 |
network_acronym_str |
UFOP |
network_name_str |
Repositório Institucional da UFOP |
repository_id_str |
3233 |
spelling |
Freitas, Renata Nascimento deKay-Tee, KhawWu, KelvinBowman, RichardJeffery, HannahLuben, RobertWareham, Nick J.Bingham, Sheila A.2017-05-11T15:25:32Z2017-05-11T15:25:32Z2010FREITAS, R. N. de et al. A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. European Journal of Cardiovascular Prevention & Rehabilitation, v. 8104, p. 765–772, 2010. Disponível em: <https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/single-nucleotide-polymorphism-in-the-3hydroxy3methylglutarylcoenzyme-a-reductase-gene-hmgcr-influences-the-serum-triacylglycerol-relationship-with-dietary-fat-and-fibre-in-the-european-prospective-investigation-into-cancer-and-nutrition-in-norfolk-epicnorfolk-study/32A4F0A1B08D32FA08E636A624C9F237>. Acesso em: 21 mar. 2017.1475-2662http://www.repositorio.ufop.br/handle/123456789/7715https://doi.org/10.1017/S0007114510001145The objective of the present study was to investigate the influence of the single nucleotide polymorphism (rs17238540) at the 3-hydroxy-3-methylglutaryl- coenzyme A reductase gene (HMGCR) on the relationship between serum lipids and dietary fat and fibre (NSP). FFQ and pyrosequencing were used to assess cross-sectional dietary intake and HMGCR genotype in a population study with data for serum lipids available. Genotype frequencies and allele distributions for 23 011 participants were: TT 95·65 %, TG 4·29% and GG 0·06 %; T 97·8% and G 2·2 %. In regression analyses, the TG þ GG group showed a significant positive relationship between TAG and SFA intake (þ0·11 (95% CI 0·02, 0·20) mmol TAG/l; P¼0·017; per 3% SFA energy increase) while the TT individuals showed no change in the TAG levels related to SFA intake (20·0007 (95% CI 20·02, 0·02) mmol TAG/l; P¼0·99). TG þ GG individuals showed an inverse relationship between TAG and fibre intake higher (20·14 (95% CI 20·22, 20·05) mmol TAG/l than the TT group (20·04 (95% CI 20·06, 20·02) mmol TAG/l). In both cases the respective coefficient regressions of TAG were different between the genotype groups (Z ¼ 2·27, P¼0·023 for SFA intake; Z ¼ 2·19, P¼0·029 for fibre intake). Individuals carrying the G allele may show a greater response in lower TAG levels with reduced SFA intake and increased fibre intake compared with those homozygous for the T allele. The effectiveness of different dietary interventions to control serum lipids may vary according to HMGCR genotype.O periódico British Journal of Nutrition permite o arquivamento da versão PDF do editor em repositório institucional. Fonte: Sherpa/Romeo <http://sherpa.ac.uk/romeo/search.php?issn=0007-1145>. Acesso em: 19 nov. 2019.info:eu-repo/semantics/openAccessSerum lipidsDietary fatDietary fibreA single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/7715/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_SingleNucleotidePolimorphism.pdfARTIGO_SingleNucleotidePolimorphism.pdfapplication/pdf115500http://www.repositorio.ufop.br/bitstream/123456789/7715/1/ARTIGO_SingleNucleotidePolimorphism.pdf4165aee76fe31f5423aaccd447ac8f6fMD51123456789/77152019-11-19 07:05:11.142oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-11-19T12:05:11Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. |
title |
A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. |
spellingShingle |
A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. Freitas, Renata Nascimento de Serum lipids Dietary fat Dietary fibre |
title_short |
A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. |
title_full |
A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. |
title_fullStr |
A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. |
title_full_unstemmed |
A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. |
title_sort |
A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. |
author |
Freitas, Renata Nascimento de |
author_facet |
Freitas, Renata Nascimento de Kay-Tee, Khaw Wu, Kelvin Bowman, Richard Jeffery, Hannah Luben, Robert Wareham, Nick J. Bingham, Sheila A. |
author_role |
author |
author2 |
Kay-Tee, Khaw Wu, Kelvin Bowman, Richard Jeffery, Hannah Luben, Robert Wareham, Nick J. Bingham, Sheila A. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Freitas, Renata Nascimento de Kay-Tee, Khaw Wu, Kelvin Bowman, Richard Jeffery, Hannah Luben, Robert Wareham, Nick J. Bingham, Sheila A. |
dc.subject.por.fl_str_mv |
Serum lipids Dietary fat Dietary fibre |
topic |
Serum lipids Dietary fat Dietary fibre |
description |
The objective of the present study was to investigate the influence of the single nucleotide polymorphism (rs17238540) at the 3-hydroxy-3-methylglutaryl- coenzyme A reductase gene (HMGCR) on the relationship between serum lipids and dietary fat and fibre (NSP). FFQ and pyrosequencing were used to assess cross-sectional dietary intake and HMGCR genotype in a population study with data for serum lipids available. Genotype frequencies and allele distributions for 23 011 participants were: TT 95·65 %, TG 4·29% and GG 0·06 %; T 97·8% and G 2·2 %. In regression analyses, the TG þ GG group showed a significant positive relationship between TAG and SFA intake (þ0·11 (95% CI 0·02, 0·20) mmol TAG/l; P¼0·017; per 3% SFA energy increase) while the TT individuals showed no change in the TAG levels related to SFA intake (20·0007 (95% CI 20·02, 0·02) mmol TAG/l; P¼0·99). TG þ GG individuals showed an inverse relationship between TAG and fibre intake higher (20·14 (95% CI 20·22, 20·05) mmol TAG/l than the TT group (20·04 (95% CI 20·06, 20·02) mmol TAG/l). In both cases the respective coefficient regressions of TAG were different between the genotype groups (Z ¼ 2·27, P¼0·023 for SFA intake; Z ¼ 2·19, P¼0·029 for fibre intake). Individuals carrying the G allele may show a greater response in lower TAG levels with reduced SFA intake and increased fibre intake compared with those homozygous for the T allele. The effectiveness of different dietary interventions to control serum lipids may vary according to HMGCR genotype. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2017-05-11T15:25:32Z |
dc.date.available.fl_str_mv |
2017-05-11T15:25:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FREITAS, R. N. de et al. A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. European Journal of Cardiovascular Prevention & Rehabilitation, v. 8104, p. 765–772, 2010. Disponível em: <https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/single-nucleotide-polymorphism-in-the-3hydroxy3methylglutarylcoenzyme-a-reductase-gene-hmgcr-influences-the-serum-triacylglycerol-relationship-with-dietary-fat-and-fibre-in-the-european-prospective-investigation-into-cancer-and-nutrition-in-norfolk-epicnorfolk-study/32A4F0A1B08D32FA08E636A624C9F237>. Acesso em: 21 mar. 2017. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/7715 |
dc.identifier.issn.none.fl_str_mv |
1475-2662 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1017/S0007114510001145 |
identifier_str_mv |
FREITAS, R. N. de et al. A single nucleotide polymorphism in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene (HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the european prospective investigation into cancer and cutrition in Norfolk (EPIC-Norfolk) study. European Journal of Cardiovascular Prevention & Rehabilitation, v. 8104, p. 765–772, 2010. Disponível em: <https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/single-nucleotide-polymorphism-in-the-3hydroxy3methylglutarylcoenzyme-a-reductase-gene-hmgcr-influences-the-serum-triacylglycerol-relationship-with-dietary-fat-and-fibre-in-the-european-prospective-investigation-into-cancer-and-nutrition-in-norfolk-epicnorfolk-study/32A4F0A1B08D32FA08E636A624C9F237>. Acesso em: 21 mar. 2017. 1475-2662 |
url |
http://www.repositorio.ufop.br/handle/123456789/7715 https://doi.org/10.1017/S0007114510001145 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
bitstream.url.fl_str_mv |
http://www.repositorio.ufop.br/bitstream/123456789/7715/2/license.txt http://www.repositorio.ufop.br/bitstream/123456789/7715/1/ARTIGO_SingleNucleotidePolimorphism.pdf |
bitstream.checksum.fl_str_mv |
62604f8d955274beb56c80ce1ee5dcae 4165aee76fe31f5423aaccd447ac8f6f |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
_version_ |
1797950173623615488 |