Factors associated with short and long term cognitive changes in patients with sepsis.
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Publication Date: | 2018 |
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Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UFOP |
Download full: | http://www.repositorio.ufop.br/handle/123456789/9924 |
Summary: | This study aimed to assess cognition in patients with severe sepsis or septic shock and whether cognitive impairment was associated with clinical and laboratory parameters. We conducted a cohort study of patients with severe sepsis and septic shock evaluated within 24 h and one year after ICU discharge. Demographic, clinical and laboratory data were analyzed, and the following neuropsychological tests were applied: Consortium to Establish Registry for Alzheimer’s Disease, Mini- Mental State Examination, and Trail Making Test forms A and B. We included 33 patients, mean age of 49, 19% were female. Patients underperformed on most measures 24 h after ICU discharge, with improvement on follow-up. IQCODE, APACHE II scores, NSE and IFN-γ levels at ICU discharge were associated with poor cognitive performance, while higher educational level was associated with good cognitive performance. The time to first antibiotic dose, accumulated dose of haloperidol during UCI stay and mean glycemia were also associated with poor cognitive outcome. In general, patients with severe sepsis or septic shock have cognitive impairment that can improve over time. This improvement was associated with factors identified during their ICU stay, such as cognitive reserve, educational level, mean glycemia during ICU stay and NSE level. |
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Calsavara, Allan Jefferson CruzCosta, Priscila A.Nobre, VandackTeixeira, Antônio Lúcio2018-05-11T12:12:48Z2018-05-11T12:12:48Z2018CALSAVARA, A. J. C. et al. Factors associated with short and long term cognitive changes in patients with Sepsis. Scientific Reports, v. 8, p. 1-10, 2018. Disponível em: <https://www.nature.com/articles/s41598-018-22754-3>. Acesso em: 05 abr. 2018.20452322http://www.repositorio.ufop.br/handle/123456789/9924This study aimed to assess cognition in patients with severe sepsis or septic shock and whether cognitive impairment was associated with clinical and laboratory parameters. We conducted a cohort study of patients with severe sepsis and septic shock evaluated within 24 h and one year after ICU discharge. Demographic, clinical and laboratory data were analyzed, and the following neuropsychological tests were applied: Consortium to Establish Registry for Alzheimer’s Disease, Mini- Mental State Examination, and Trail Making Test forms A and B. We included 33 patients, mean age of 49, 19% were female. Patients underperformed on most measures 24 h after ICU discharge, with improvement on follow-up. IQCODE, APACHE II scores, NSE and IFN-γ levels at ICU discharge were associated with poor cognitive performance, while higher educational level was associated with good cognitive performance. The time to first antibiotic dose, accumulated dose of haloperidol during UCI stay and mean glycemia were also associated with poor cognitive outcome. In general, patients with severe sepsis or septic shock have cognitive impairment that can improve over time. This improvement was associated with factors identified during their ICU stay, such as cognitive reserve, educational level, mean glycemia during ICU stay and NSE level.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Fonte: o próprio artigo.info:eu-repo/semantics/openAccessFactors associated with short and long term cognitive changes in patients with sepsis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/9924/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_FactorsAssociatedShort.pdfARTIGO_FactorsAssociatedShort.pdfapplication/pdf1567799http://www.repositorio.ufop.br/bitstream/123456789/9924/1/ARTIGO_FactorsAssociatedShort.pdfeefc8bd821ef4d5b84ca060e9a77c1f2MD51123456789/99242018-05-11 08:12:48.701oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332018-05-11T12:12:48Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Factors associated with short and long term cognitive changes in patients with sepsis. |
title |
Factors associated with short and long term cognitive changes in patients with sepsis. |
spellingShingle |
Factors associated with short and long term cognitive changes in patients with sepsis. Calsavara, Allan Jefferson Cruz |
title_short |
Factors associated with short and long term cognitive changes in patients with sepsis. |
title_full |
Factors associated with short and long term cognitive changes in patients with sepsis. |
title_fullStr |
Factors associated with short and long term cognitive changes in patients with sepsis. |
title_full_unstemmed |
Factors associated with short and long term cognitive changes in patients with sepsis. |
title_sort |
Factors associated with short and long term cognitive changes in patients with sepsis. |
author |
Calsavara, Allan Jefferson Cruz |
author_facet |
Calsavara, Allan Jefferson Cruz Costa, Priscila A. Nobre, Vandack Teixeira, Antônio Lúcio |
author_role |
author |
author2 |
Costa, Priscila A. Nobre, Vandack Teixeira, Antônio Lúcio |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Calsavara, Allan Jefferson Cruz Costa, Priscila A. Nobre, Vandack Teixeira, Antônio Lúcio |
description |
This study aimed to assess cognition in patients with severe sepsis or septic shock and whether cognitive impairment was associated with clinical and laboratory parameters. We conducted a cohort study of patients with severe sepsis and septic shock evaluated within 24 h and one year after ICU discharge. Demographic, clinical and laboratory data were analyzed, and the following neuropsychological tests were applied: Consortium to Establish Registry for Alzheimer’s Disease, Mini- Mental State Examination, and Trail Making Test forms A and B. We included 33 patients, mean age of 49, 19% were female. Patients underperformed on most measures 24 h after ICU discharge, with improvement on follow-up. IQCODE, APACHE II scores, NSE and IFN-γ levels at ICU discharge were associated with poor cognitive performance, while higher educational level was associated with good cognitive performance. The time to first antibiotic dose, accumulated dose of haloperidol during UCI stay and mean glycemia were also associated with poor cognitive outcome. In general, patients with severe sepsis or septic shock have cognitive impairment that can improve over time. This improvement was associated with factors identified during their ICU stay, such as cognitive reserve, educational level, mean glycemia during ICU stay and NSE level. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-05-11T12:12:48Z |
dc.date.available.fl_str_mv |
2018-05-11T12:12:48Z |
dc.date.issued.fl_str_mv |
2018 |
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article |
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dc.identifier.citation.fl_str_mv |
CALSAVARA, A. J. C. et al. Factors associated with short and long term cognitive changes in patients with Sepsis. Scientific Reports, v. 8, p. 1-10, 2018. Disponível em: <https://www.nature.com/articles/s41598-018-22754-3>. Acesso em: 05 abr. 2018. |
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http://www.repositorio.ufop.br/handle/123456789/9924 |
dc.identifier.issn.none.fl_str_mv |
20452322 |
identifier_str_mv |
CALSAVARA, A. J. C. et al. Factors associated with short and long term cognitive changes in patients with Sepsis. Scientific Reports, v. 8, p. 1-10, 2018. Disponível em: <https://www.nature.com/articles/s41598-018-22754-3>. Acesso em: 05 abr. 2018. 20452322 |
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