Histopathology of Leishmania major infection : revisiting L. major histopathology in the ear dermis infection model.

• Autor(a) principal: Cangussú, Silvia Dantas
• Data de Publicação: 2009
• Outros Autores: Souza, Carolina Carvalho de, Campos, Camila França, Vieira, Leda Quercia, Afonso, Luís Carlos Crocco, Arantes, Rosa Maria Esteves
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/handle/123456789/4523; http://dx.doi.org/10.1590/S0074-02762009000600017
• topic: Leishmania major; Infectious skin diseases; Pathology

We describe the relationship between lesion outcome and histopathological hallmarks in susceptible (BALB/c) and resistant (C57BL/6 and IL-4-deficient BALB/c) mouse strains over the course of a 12-week-infection with Leishmania major in the ear. The infiltration of mononuclear cells and polymorphonuclear cells occurred within 6 h and mononuclear cells predominated one week post-infection. Permissive intracellular growth of the pathogen was associated with non-healing lesions. In contrast, tissue damage and clearance of the parasite was observed in healing lesions and was associated with inducible nitric oxide synthase expression. The identification of the struc¬tural components of tissue reaction to the parasite in this study furthers our understanding of subjacent immune effector mechanisms.