Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.

Detalhes bibliográficos
Autor(a) principal: Li, Xiao Hong
Data de Publicação: 2018
Outros Autores: DeMarco, Ricardo, Neves, Leandro Xavier, James, Sally R., Newling, Katherine, Ashton, Peter D., Cao, Jian Ping, Wilson, R. Alan, Borges, William de Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/9919
Resumo: Adult schistosomes have a well-developed alimentary tract comprising an oral sucker around the mouth, a short esophagus and a blind ending gut. The esophagus is not simply a muscular tube for conducting blood from the mouth to gut but is divided into compartments, surrounded by anterior and posterior glands, where processing of ingested blood is initiated. Self-cure of rhesus macaques from a Schistosoma japonicum infection appears to operate by blocking the secretory functions of these glands so that the worms cease feeding and slowly starve to death. Here we use subtractive RNASeq to characterise the genes encoding the principal secretory products of S. japonicum esophageal glands, preparatory to evaluating their relevance as targets of the self-cure process.
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spelling Li, Xiao HongDeMarco, RicardoNeves, Leandro XavierJames, Sally R.Newling, KatherineAshton, Peter D.Cao, Jian PingWilson, R. AlanBorges, William de Castro2018-05-11T11:53:55Z2018-05-11T11:53:55Z2018LI, X. H. et al. Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus. PLoS Neglected Tropical Diseases, v. 12, p. 1-22, 2018. Disponível em: <http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006235>. Acesso em: 05 abr. 2018.19352735http://www.repositorio.ufop.br/handle/123456789/9919Adult schistosomes have a well-developed alimentary tract comprising an oral sucker around the mouth, a short esophagus and a blind ending gut. The esophagus is not simply a muscular tube for conducting blood from the mouth to gut but is divided into compartments, surrounded by anterior and posterior glands, where processing of ingested blood is initiated. Self-cure of rhesus macaques from a Schistosoma japonicum infection appears to operate by blocking the secretory functions of these glands so that the worms cease feeding and slowly starve to death. Here we use subtractive RNASeq to characterise the genes encoding the principal secretory products of S. japonicum esophageal glands, preparatory to evaluating their relevance as targets of the self-cure process.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fonte: Plos One <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172103> .Acesso em: 30 jul. 2017.info:eu-repo/semantics/openAccessMicroexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/9919/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_MicroexonGeneTranscriptional.pdfARTIGO_MicroexonGeneTranscriptional.pdfapplication/pdf4859443http://www.repositorio.ufop.br/bitstream/123456789/9919/1/ARTIGO_MicroexonGeneTranscriptional.pdf93d6ea86d24197dc5a842d4bd3e78b17MD51123456789/99192018-05-11 07:53:55.816oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332018-05-11T11:53:55Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.pt_BR.fl_str_mv Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.
title Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.
spellingShingle Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.
Li, Xiao Hong
title_short Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.
title_full Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.
title_fullStr Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.
title_full_unstemmed Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.
title_sort Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus.
author Li, Xiao Hong
author_facet Li, Xiao Hong
DeMarco, Ricardo
Neves, Leandro Xavier
James, Sally R.
Newling, Katherine
Ashton, Peter D.
Cao, Jian Ping
Wilson, R. Alan
Borges, William de Castro
author_role author
author2 DeMarco, Ricardo
Neves, Leandro Xavier
James, Sally R.
Newling, Katherine
Ashton, Peter D.
Cao, Jian Ping
Wilson, R. Alan
Borges, William de Castro
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Li, Xiao Hong
DeMarco, Ricardo
Neves, Leandro Xavier
James, Sally R.
Newling, Katherine
Ashton, Peter D.
Cao, Jian Ping
Wilson, R. Alan
Borges, William de Castro
description Adult schistosomes have a well-developed alimentary tract comprising an oral sucker around the mouth, a short esophagus and a blind ending gut. The esophagus is not simply a muscular tube for conducting blood from the mouth to gut but is divided into compartments, surrounded by anterior and posterior glands, where processing of ingested blood is initiated. Self-cure of rhesus macaques from a Schistosoma japonicum infection appears to operate by blocking the secretory functions of these glands so that the worms cease feeding and slowly starve to death. Here we use subtractive RNASeq to characterise the genes encoding the principal secretory products of S. japonicum esophageal glands, preparatory to evaluating their relevance as targets of the self-cure process.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-05-11T11:53:55Z
dc.date.available.fl_str_mv 2018-05-11T11:53:55Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv LI, X. H. et al. Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus. PLoS Neglected Tropical Diseases, v. 12, p. 1-22, 2018. Disponível em: <http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006235>. Acesso em: 05 abr. 2018.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufop.br/handle/123456789/9919
dc.identifier.issn.none.fl_str_mv 19352735
identifier_str_mv LI, X. H. et al. Microexon gene transcriptional profiles and evolution provide insights into blood processing by the Schistosoma japonicum esophagus. PLoS Neglected Tropical Diseases, v. 12, p. 1-22, 2018. Disponível em: <http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006235>. Acesso em: 05 abr. 2018.
19352735
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