Early treatment of COVID-19 based on scientific evidence

Detalhes bibliográficos
Autor(a) principal: Vieira, Sabas Carlos
Data de Publicação: 2020
Outros Autores: Fontinele, Danilo Rafael da Silva, Barjud, Marina Bucar, de Carvalho Junior, Justino Moreira, Melo, Lina Madeira Campos, Fonseca Filho, José Wilson, Prado, Gerson Luís Medina, Alencar, Alexandre Adad
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira em Promoção da Saúde
Texto Completo: https://ojs.unifor.br/RBPS/article/view/10993
Resumo: Objective: To present a proposal for early treatment of patients with COVID-19 in a Primary Health Care (PHC) center. Methods: This is a proposed treatment protocol for COVID-19 using hydroxychloroquine or chloroquine based on the currently (June 13, 2020) available scientific literature. PubMed database was searched for studies using the descriptors COVID-19, hydroxychloroquine, and chloroquine. Five studies were selected from the 645 studies found as they addressed the use of hydroxychloroquine or chloroquine in the treatment of COVID-19 in early stages. Results: The proposed early treatment protocol for patients with suspected COVID-19 includes guidance on the main symptoms, general guidelines for the population, medical evaluation, examination considerations, recommended therapy, post-prescription guidelines and criteria for hospitalization. Conclusion: According to the studies, early outpatient treatment of COVID-19 with hydroxychloroquine or chloroquine seems to decrease the risk of hospitalization and the need for intensive care beds. The decision to adopt the proposed treatment is made by the patient, and the physician should only conduct the treatment after obtaining written informed consent from the patient, as it is an off-label prescription. Randomized studies are needed to confirm this hypothesis.
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spelling Early treatment of COVID-19 based on scientific evidenceTratamiento precoz para COVID-19 basado en evidencia científicaTratamento precoce para COVID-19 baseado em evidência científicaProtocolsTherapeuticsCoronavirus InfectionsProtocolosTerapéuticaInfecciones por CoronavirusProtocolosTerapêuticaInfecções por CoronavirusObjective: To present a proposal for early treatment of patients with COVID-19 in a Primary Health Care (PHC) center. Methods: This is a proposed treatment protocol for COVID-19 using hydroxychloroquine or chloroquine based on the currently (June 13, 2020) available scientific literature. PubMed database was searched for studies using the descriptors COVID-19, hydroxychloroquine, and chloroquine. Five studies were selected from the 645 studies found as they addressed the use of hydroxychloroquine or chloroquine in the treatment of COVID-19 in early stages. Results: The proposed early treatment protocol for patients with suspected COVID-19 includes guidance on the main symptoms, general guidelines for the population, medical evaluation, examination considerations, recommended therapy, post-prescription guidelines and criteria for hospitalization. Conclusion: According to the studies, early outpatient treatment of COVID-19 with hydroxychloroquine or chloroquine seems to decrease the risk of hospitalization and the need for intensive care beds. The decision to adopt the proposed treatment is made by the patient, and the physician should only conduct the treatment after obtaining written informed consent from the patient, as it is an off-label prescription. Randomized studies are needed to confirm this hypothesis.Objetivo: Presentar una propuesta de tratamiento precoz para pacientes con la COVID-19 en Unidad Básica de Salud (UBS). Métodos: Se trata de una propuesta de protocolo de tratamiento para la COVID-19 con hidrocloroquina o cloroquina basado en la literatura científica disponible en el momento (13 de junio de 2020). La recogida de los estudios se dio en la base de datos PubMed a través de los descriptores COVID-19, hydroxychloroquine y chloroquine. De los 645 artículos encontrados se ha elegido cinco de ellos sobre el uso de la hidrocloroquina o cloroquina para el tratamiento de la fase precoz de la COVID-19. Resultados: En la propuesta del protocolo para el tratamiento precoz de pacientes con sospecha de la COVID-19 hay orientaciones de los síntomas principales, las orientaciones generales para la población, la evaluación médica, las consideraciones de las pruebas, la terapia recomendada, las orientaciones post prescripición y los criterios para el ingreso hospitalario. Conclusión: Basados en estudios, el tratamiento precoz de ambulatorio de la COVID-19 con hidrocloroquina o cloroquina parece disminuir el riesgo de ingreso hospitalario y la necesidad de camas de la unidad de cuidados intensivos. La decisión para la adhesión al tratamiento propuesto es del paciente y el medico solo debe iniciarlo tras la firma del consentimiento libre esclarecido de parte del paciente una vez que se trata de prescripción off label. Son necesarios estudios randomizados para confirmar esa hipótesis.Objetivo: Apresentar uma proposta de tratamento precoce para pacientes com COVID-19 em Unidade Básica de Saúde (UBS). Métodos: Trata-se de uma proposta de protocolo de tratamento para COVID-19 com hidroxicloroquina ou cloroquina com base na literatura científica disponível no momento (13 de junho de 2020). O levantamento dos estudos ocorreu na base PubMed, por meio dos descritores COVID-19, hydroxychloroquine e chloroquine. Foram selecionados cinco artigos, dos 645 artigos encontrados, por abordarem o uso de hidroxicloroquina ou cloroquina no tratamento da fase precoce da COVID-19. Resultados: A proposta de protocolo para tratamento precoce para pacientes com suspeita de COVID-19 envolve orientações sobre os principais sintomas, orientações gerais à população, avaliação médica, considerações sobre exames, terapia recomendada, orientações pós prescrição e critérios para internação. Conclusão: Baseado em estudos, o tratamento precoce ambulatorial da COVID-19 com hidroxicloroquina ou cloroquina parece diminuir o risco de internação e, assim, a necessidade de leitos de terapia intensiva. A decisão de adoção do tratamento a ser proposto é do paciente, e o médico só deve adotar após o paciente assinar o consentimento livre e esclarecido, por tratar-se de prescrição off label. Estudos randomizados são necessários para confirmar essa hipótese.Universidade de Fortaleza2020-07-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Peer-reviewed Article""Avaliado pelos pares""Avaliado pelos pares"application/pdfapplication/pdfhttps://ojs.unifor.br/RBPS/article/view/1099310.5020/18061230.2020.10993Brazilian Journal in Health Promotion; Vol. 33 (2020)Revista Brasileña en Promoción de la Salud; Vol. 33 (2020)Revista Brasileira em Promoção da Saúde; v. 33 (2020)1806-1230reponame:Revista Brasileira em Promoção da Saúdeinstname:Universidade de Fortaleza (Unifor)instacron:UFORporenghttps://ojs.unifor.br/RBPS/article/view/10993/pdfhttps://ojs.unifor.br/RBPS/article/view/10993/pdf_1Copyright (c) 2020 Revista Brasileira em Promoção da Saúdeinfo:eu-repo/semantics/openAccessVieira, Sabas CarlosFontinele, Danilo Rafael da SilvaBarjud, Marina Bucarde Carvalho Junior, Justino MoreiraMelo, Lina Madeira CamposFonseca Filho, José WilsonPrado, Gerson Luís MedinaAlencar, Alexandre Adad2020-12-09T14:40:29Zoai:ojs.ojs.unifor.br:article/10993Revistahttps://periodicos.unifor.br/RBPS/oai1806-12301806-1222opendoar:2020-12-09T14:40:29Revista Brasileira em Promoção da Saúde - Universidade de Fortaleza (Unifor)false
dc.title.none.fl_str_mv Early treatment of COVID-19 based on scientific evidence
Tratamiento precoz para COVID-19 basado en evidencia científica
Tratamento precoce para COVID-19 baseado em evidência científica
title Early treatment of COVID-19 based on scientific evidence
spellingShingle Early treatment of COVID-19 based on scientific evidence
Vieira, Sabas Carlos
Protocols
Therapeutics
Coronavirus Infections
Protocolos
Terapéutica
Infecciones por Coronavirus
Protocolos
Terapêutica
Infecções por Coronavirus
title_short Early treatment of COVID-19 based on scientific evidence
title_full Early treatment of COVID-19 based on scientific evidence
title_fullStr Early treatment of COVID-19 based on scientific evidence
title_full_unstemmed Early treatment of COVID-19 based on scientific evidence
title_sort Early treatment of COVID-19 based on scientific evidence
author Vieira, Sabas Carlos
author_facet Vieira, Sabas Carlos
Fontinele, Danilo Rafael da Silva
Barjud, Marina Bucar
de Carvalho Junior, Justino Moreira
Melo, Lina Madeira Campos
Fonseca Filho, José Wilson
Prado, Gerson Luís Medina
Alencar, Alexandre Adad
author_role author
author2 Fontinele, Danilo Rafael da Silva
Barjud, Marina Bucar
de Carvalho Junior, Justino Moreira
Melo, Lina Madeira Campos
Fonseca Filho, José Wilson
Prado, Gerson Luís Medina
Alencar, Alexandre Adad
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vieira, Sabas Carlos
Fontinele, Danilo Rafael da Silva
Barjud, Marina Bucar
de Carvalho Junior, Justino Moreira
Melo, Lina Madeira Campos
Fonseca Filho, José Wilson
Prado, Gerson Luís Medina
Alencar, Alexandre Adad
dc.subject.por.fl_str_mv Protocols
Therapeutics
Coronavirus Infections
Protocolos
Terapéutica
Infecciones por Coronavirus
Protocolos
Terapêutica
Infecções por Coronavirus
topic Protocols
Therapeutics
Coronavirus Infections
Protocolos
Terapéutica
Infecciones por Coronavirus
Protocolos
Terapêutica
Infecções por Coronavirus
description Objective: To present a proposal for early treatment of patients with COVID-19 in a Primary Health Care (PHC) center. Methods: This is a proposed treatment protocol for COVID-19 using hydroxychloroquine or chloroquine based on the currently (June 13, 2020) available scientific literature. PubMed database was searched for studies using the descriptors COVID-19, hydroxychloroquine, and chloroquine. Five studies were selected from the 645 studies found as they addressed the use of hydroxychloroquine or chloroquine in the treatment of COVID-19 in early stages. Results: The proposed early treatment protocol for patients with suspected COVID-19 includes guidance on the main symptoms, general guidelines for the population, medical evaluation, examination considerations, recommended therapy, post-prescription guidelines and criteria for hospitalization. Conclusion: According to the studies, early outpatient treatment of COVID-19 with hydroxychloroquine or chloroquine seems to decrease the risk of hospitalization and the need for intensive care beds. The decision to adopt the proposed treatment is made by the patient, and the physician should only conduct the treatment after obtaining written informed consent from the patient, as it is an off-label prescription. Randomized studies are needed to confirm this hypothesis.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
"Peer-reviewed Article"
"Avaliado pelos pares"
"Avaliado pelos pares"
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.unifor.br/RBPS/article/view/10993
10.5020/18061230.2020.10993
url https://ojs.unifor.br/RBPS/article/view/10993
identifier_str_mv 10.5020/18061230.2020.10993
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://ojs.unifor.br/RBPS/article/view/10993/pdf
https://ojs.unifor.br/RBPS/article/view/10993/pdf_1
dc.rights.driver.fl_str_mv Copyright (c) 2020 Revista Brasileira em Promoção da Saúde
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Revista Brasileira em Promoção da Saúde
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade de Fortaleza
publisher.none.fl_str_mv Universidade de Fortaleza
dc.source.none.fl_str_mv Brazilian Journal in Health Promotion; Vol. 33 (2020)
Revista Brasileña en Promoción de la Salud; Vol. 33 (2020)
Revista Brasileira em Promoção da Saúde; v. 33 (2020)
1806-1230
reponame:Revista Brasileira em Promoção da Saúde
instname:Universidade de Fortaleza (Unifor)
instacron:UFOR
instname_str Universidade de Fortaleza (Unifor)
instacron_str UFOR
institution UFOR
reponame_str Revista Brasileira em Promoção da Saúde
collection Revista Brasileira em Promoção da Saúde
repository.name.fl_str_mv Revista Brasileira em Promoção da Saúde - Universidade de Fortaleza (Unifor)
repository.mail.fl_str_mv
_version_ 1754638941630234624

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