Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam

Detalhes bibliográficos
Autor(a) principal: BOTELHO, Nara Macedo
Data de Publicação: 2013
Outros Autores: CORRÊA, Suelen Costa, LOBATO, Rodolfo Costa, TEIXEIRA, Renan Kleber Costa, QUARESMA, Juarez Antônio Simões, http://orcid.org/0000-0002-5079-297X, https://orcid.org/0000-0002-6267-9966
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFPA
Texto Completo: http://repositorio.ufpa.br/jspui/handle/2011/4418
http://dx.doi.org/10.1590/S0102-86502013000300005
Resumo: PURPOSE: To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis). METHODS: The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12th day, after euthanasia, the tumor pieces were sent to the identification of T CD4+, T CD8+ and Natural Killer cells. RESULTS: It was found that the pattern of expression for specific markers of phenotypes of cells involved in tumor immune response was similar in all groups, regardless the administration way of copaiba oil (topical or gavage). CONCLUSION: Copaiba balsam, administered either topically or by gavage, did not alter the pattern of tumor immune response in rats bearing Walker 256 Tumor.
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spelling 2013-11-08T13:07:59Z2013-11-08T13:07:59Z2013-03BOTELHO, Nara Macedo, et al. Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 3, p. 185-189, Mar. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000300005. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/4418. Acesso em:.1678-2674http://repositorio.ufpa.br/jspui/handle/2011/4418http://dx.doi.org/10.1590/S0102-86502013000300005PURPOSE: To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis). METHODS: The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12th day, after euthanasia, the tumor pieces were sent to the identification of T CD4+, T CD8+ and Natural Killer cells. RESULTS: It was found that the pattern of expression for specific markers of phenotypes of cells involved in tumor immune response was similar in all groups, regardless the administration way of copaiba oil (topical or gavage). CONCLUSION: Copaiba balsam, administered either topically or by gavage, did not alter the pattern of tumor immune response in rats bearing Walker 256 Tumor.FAPESPA - Fundação Amazônia de Amparo a Estudos e PesquisasQUARESMA, J. A. S. Universidade Federal do ParáengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaSOBRADPECBrasilActa Cirúrgica Brasileirahttp://ref.scielo.org/qdsjc7reponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPACarcinoma 256 de WalkerCerclagem cervicalImunoistoquímicaCopaíbaImmunohistochemistryCervix uteriRatsImmunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsaminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article283185189http://lattes.cnpq.br/5088569652644480http://lattes.cnpq.br/3945331133921104http://lattes.cnpq.br/3361650893566450http://lattes.cnpq.br/5246017785240786http://lattes.cnpq.br/3350166863853054BOTELHO, Nara MacedoCORRÊA, Suelen CostaLOBATO, Rodolfo CostaTEIXEIRA, Renan Kleber CostaQUARESMA, Juarez Antônio Simõeshttp://orcid.org/0000-0002-5079-297Xhttps://orcid.org/0000-0002-6267-9966info:eu-repo/semantics/openAccessORIGINALArticle_ImmunohistochemistryUterine.pdfArticle_ImmunohistochemistryUterine.pdfapplication/pdf472882http://repositorio.ufpa.br/oai/bitstream/2011/4418/1/Article_ImmunohistochemistryUterine.pdff85becb3a5692f0720e38d1fa58a5f7bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81774http://repositorio.ufpa.br/oai/bitstream/2011/4418/2/license.txtf0aa1a71c97d9c3e771021efac6d65e7MD52TEXTArtigo_ImmunohistochemistryUterine.pdf.txtArtigo_ImmunohistochemistryUterine.pdf.txtExtracted texttext/plain15253http://repositorio.ufpa.br/oai/bitstream/2011/4418/3/Artigo_ImmunohistochemistryUterine.pdf.txt1d141077d8f663bc917f01cd133af162MD53Article_ImmunohistochemistryUterine.pdf.txtArticle_ImmunohistochemistryUterine.pdf.txtExtracted texttext/plain15253http://repositorio.ufpa.br/oai/bitstream/2011/4418/4/Article_ImmunohistochemistryUterine.pdf.txt1d141077d8f663bc917f01cd133af162MD542011/44182020-01-30 02:34:18.531oai:repositorio.ufpa.br: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Repositório InstitucionalPUBhttp://repositorio.ufpa.br/oai/requestriufpabc@ufpa.bropendoar:21232020-01-30T05:34:18Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA)false
dc.title.en.fl_str_mv Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam
title Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam
spellingShingle Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam
BOTELHO, Nara Macedo
Carcinoma 256 de Walker
Cerclagem cervical
Imunoistoquímica
Copaíba
Immunohistochemistry
Cervix uteri
Rats
title_short Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam
title_full Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam
title_fullStr Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam
title_full_unstemmed Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam
title_sort Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam
author BOTELHO, Nara Macedo
author_facet BOTELHO, Nara Macedo
CORRÊA, Suelen Costa
LOBATO, Rodolfo Costa
TEIXEIRA, Renan Kleber Costa
QUARESMA, Juarez Antônio Simões
http://orcid.org/0000-0002-5079-297X
https://orcid.org/0000-0002-6267-9966
author_role author
author2 CORRÊA, Suelen Costa
LOBATO, Rodolfo Costa
TEIXEIRA, Renan Kleber Costa
QUARESMA, Juarez Antônio Simões
http://orcid.org/0000-0002-5079-297X
https://orcid.org/0000-0002-6267-9966
author2_role author
author
author
author
author
author
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/5088569652644480
http://lattes.cnpq.br/3945331133921104
http://lattes.cnpq.br/3361650893566450
http://lattes.cnpq.br/5246017785240786
http://lattes.cnpq.br/3350166863853054
dc.contributor.author.fl_str_mv BOTELHO, Nara Macedo
CORRÊA, Suelen Costa
LOBATO, Rodolfo Costa
TEIXEIRA, Renan Kleber Costa
QUARESMA, Juarez Antônio Simões
http://orcid.org/0000-0002-5079-297X
https://orcid.org/0000-0002-6267-9966
dc.subject.por.fl_str_mv Carcinoma 256 de Walker
Cerclagem cervical
Imunoistoquímica
Copaíba
topic Carcinoma 256 de Walker
Cerclagem cervical
Imunoistoquímica
Copaíba
Immunohistochemistry
Cervix uteri
Rats
dc.subject.eng.fl_str_mv Immunohistochemistry
Cervix uteri
Rats
description PURPOSE: To investigate the immunohistochemistry of the uterine cervix of 20 Wistar rats (Rattus norvegicus) bearing the Walker 256 tumor, treated with copaiba oil (Copaifera officinalis). METHODS: The animals were grouped into four subgroups, with five rats each: the GCT and GCopT received distilled water and topically copaiba, respectively, while the GCG and GCopG received distilled water and copaiba by gavage, respectively. The substances were administered for nine days. On the 12th day, after euthanasia, the tumor pieces were sent to the identification of T CD4+, T CD8+ and Natural Killer cells. RESULTS: It was found that the pattern of expression for specific markers of phenotypes of cells involved in tumor immune response was similar in all groups, regardless the administration way of copaiba oil (topical or gavage). CONCLUSION: Copaiba balsam, administered either topically or by gavage, did not alter the pattern of tumor immune response in rats bearing Walker 256 Tumor.
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-11-08T13:07:59Z
dc.date.available.fl_str_mv 2013-11-08T13:07:59Z
dc.date.issued.fl_str_mv 2013-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BOTELHO, Nara Macedo, et al. Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 3, p. 185-189, Mar. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000300005. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/4418. Acesso em:.
dc.identifier.uri.fl_str_mv http://repositorio.ufpa.br/jspui/handle/2011/4418
dc.identifier.issn.none.fl_str_mv 1678-2674
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S0102-86502013000300005
identifier_str_mv BOTELHO, Nara Macedo, et al. Immunohistochemistry of the uterine cervix of rats bearing the Walker 256 tumor treated with copaiba balsam. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 3, p. 185-189, Mar. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000300005. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/4418. Acesso em:.
1678-2674
url http://repositorio.ufpa.br/jspui/handle/2011/4418
http://dx.doi.org/10.1590/S0102-86502013000300005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Acta Cirúrgica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.publisher.initials.fl_str_mv SOBRADPEC
dc.publisher.country.fl_str_mv Brasil
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFPA
instname:Universidade Federal do Pará (UFPA)
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instname_str Universidade Federal do Pará (UFPA)
instacron_str UFPA
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