Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFPA |
Texto Completo: | http://repositorio.ufpa.br/jspui/handle/2011/3944 |
Resumo: | Mikania lindleyana DC., Asteraceae (sucuriju), grows in the Amazon region, where is frequently used to treat pain, inflammatory diseases and scarring. This study was carried out to investigate phytochemical profile accompanied by in vivo antinociceptive and anti-inflammatory screening of n-hexane (HE), dichloromethane (DME) and methanol (ME) extracts obtained from the aerial parts of the plant. The oral administration of ME (0.1, 0.3, 1 g/kg) caused a dose-related reduction (16.2, 42.1 e 70.2%) of acetic acid-induced abdominal writhing while HE and DME (1 g/kg, p.o.) were ineffective. In the hot plate test, ME (300 mg/kg, p.o.) increased the latency of heat stimulus between 30 and 120 min and inhibited the first (45%) and second (60%) phases of nociception in the formalin test. The antinociception induced by ME or positive control fentanyl (150 µg/kg, s.c.) in hot plate and formalin tests was prevented by naloxone (3 mg/kg, s.c.). When submitted to the carrageenan-induced peritonitis test, ME (0.5, 1.0, 2.0 g/kg, p.o.) impaired leukocyte migration into the peritoneal cavity by 46.8, 59.4 and 64.8% respectively, while positive control dexamethasone (2 mg/kg, s.c.), inhibited leukocyte migration by 71.1%. These results indicate that the antinociception obtained after oral administration of methanol extract of M. lindleyana involves anti-inflammatory mechanisms accompanied with opioid-like activity which could explain the use of the specie for pain and inflammatory diseases. |
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2013-06-03T13:13:51Z2013-06-03T13:13:51Z2012-02VANDERLINDE, Frederico A., et al. Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, p. 150-156, jan./fev. 2012, Epub 14 out. 2011. Disponível em: <http://www.scielo.br/pdf/rbfar/v22n1/aop18511.pdf>. Acesso em: 29 maio 2013. <http://dx.doi.org/10.1590/S0102-695X2011005000190>.0102-695Xhttp://repositorio.ufpa.br/jspui/handle/2011/3944Mikania lindleyana DC., Asteraceae (sucuriju), grows in the Amazon region, where is frequently used to treat pain, inflammatory diseases and scarring. This study was carried out to investigate phytochemical profile accompanied by in vivo antinociceptive and anti-inflammatory screening of n-hexane (HE), dichloromethane (DME) and methanol (ME) extracts obtained from the aerial parts of the plant. The oral administration of ME (0.1, 0.3, 1 g/kg) caused a dose-related reduction (16.2, 42.1 e 70.2%) of acetic acid-induced abdominal writhing while HE and DME (1 g/kg, p.o.) were ineffective. In the hot plate test, ME (300 mg/kg, p.o.) increased the latency of heat stimulus between 30 and 120 min and inhibited the first (45%) and second (60%) phases of nociception in the formalin test. The antinociception induced by ME or positive control fentanyl (150 µg/kg, s.c.) in hot plate and formalin tests was prevented by naloxone (3 mg/kg, s.c.). When submitted to the carrageenan-induced peritonitis test, ME (0.5, 1.0, 2.0 g/kg, p.o.) impaired leukocyte migration into the peritoneal cavity by 46.8, 59.4 and 64.8% respectively, while positive control dexamethasone (2 mg/kg, s.c.), inhibited leukocyte migration by 71.1%. These results indicate that the antinociception obtained after oral administration of methanol extract of M. lindleyana involves anti-inflammatory mechanisms accompanied with opioid-like activity which could explain the use of the specie for pain and inflammatory diseases.engFitoterapiaAgentes antiinflamatóriosAnalgésicosMikania lindleyanaAsteraceaeSucurijuBelém - PAPará - EstadoAmazônia brasileiraAnti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucurijuinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVANDERLINDE, Frederico ArgolloROCHA, Fabio Fagundes daMALVAR, David do CarmoFERREIRA, Raquel TeixeiraCOSTA, Elson AlvesFLORENTINO, Iziara FerreiraGUILHON, Giselle Maria Skelding PinheiroLIMA, Thereza Christina Monteiro deinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPAORIGINALArtigo_Anti-inflammatoryOpioid-like.pdfArtigo_Anti-inflammatoryOpioid-like.pdfapplication/pdf766022http://repositorio.ufpa.br/oai/bitstream/2011/3944/1/Artigo_Anti-inflammatoryOpioid-like.pdfc833a769f01ed6bdaf1b6b002e8e8191MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://repositorio.ufpa.br/oai/bitstream/2011/3944/2/license_urlfd26723f8d7edacdb29e3f03465c3b03MD52license_textlicense_texttext/html; charset=utf-80http://repositorio.ufpa.br/oai/bitstream/2011/3944/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-823599http://repositorio.ufpa.br/oai/bitstream/2011/3944/4/license_rdf9e2b7f6edbd693264102b96ece20428aMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81996http://repositorio.ufpa.br/oai/bitstream/2011/3944/5/license.txt4b350777eea7a4b1ae7cd9a06fd687a1MD55TEXTArtigo_Anti-inflammatoryOpioid-like.pdf.txtArtigo_Anti-inflammatoryOpioid-like.pdf.txtExtracted texttext/plain32636http://repositorio.ufpa.br/oai/bitstream/2011/3944/6/Artigo_Anti-inflammatoryOpioid-like.pdf.txtc95a012d4468431c0780913e5eb33a9aMD562011/39442019-05-23 10:25:55.841oai:repositorio.ufpa.br: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Repositório InstitucionalPUBhttp://repositorio.ufpa.br/oai/requestriufpabc@ufpa.bropendoar:21232019-05-23T13:25:55Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA)false |
dc.title.pt_BR.fl_str_mv |
Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju |
title |
Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju |
spellingShingle |
Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju VANDERLINDE, Frederico Argollo Fitoterapia Agentes antiinflamatórios Analgésicos Mikania lindleyana Asteraceae Sucuriju Belém - PA Pará - Estado Amazônia brasileira |
title_short |
Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju |
title_full |
Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju |
title_fullStr |
Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju |
title_full_unstemmed |
Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju |
title_sort |
Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju |
author |
VANDERLINDE, Frederico Argollo |
author_facet |
VANDERLINDE, Frederico Argollo ROCHA, Fabio Fagundes da MALVAR, David do Carmo FERREIRA, Raquel Teixeira COSTA, Elson Alves FLORENTINO, Iziara Ferreira GUILHON, Giselle Maria Skelding Pinheiro LIMA, Thereza Christina Monteiro de |
author_role |
author |
author2 |
ROCHA, Fabio Fagundes da MALVAR, David do Carmo FERREIRA, Raquel Teixeira COSTA, Elson Alves FLORENTINO, Iziara Ferreira GUILHON, Giselle Maria Skelding Pinheiro LIMA, Thereza Christina Monteiro de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
VANDERLINDE, Frederico Argollo ROCHA, Fabio Fagundes da MALVAR, David do Carmo FERREIRA, Raquel Teixeira COSTA, Elson Alves FLORENTINO, Iziara Ferreira GUILHON, Giselle Maria Skelding Pinheiro LIMA, Thereza Christina Monteiro de |
dc.subject.por.fl_str_mv |
Fitoterapia Agentes antiinflamatórios Analgésicos Mikania lindleyana Asteraceae Sucuriju Belém - PA Pará - Estado Amazônia brasileira |
topic |
Fitoterapia Agentes antiinflamatórios Analgésicos Mikania lindleyana Asteraceae Sucuriju Belém - PA Pará - Estado Amazônia brasileira |
description |
Mikania lindleyana DC., Asteraceae (sucuriju), grows in the Amazon region, where is frequently used to treat pain, inflammatory diseases and scarring. This study was carried out to investigate phytochemical profile accompanied by in vivo antinociceptive and anti-inflammatory screening of n-hexane (HE), dichloromethane (DME) and methanol (ME) extracts obtained from the aerial parts of the plant. The oral administration of ME (0.1, 0.3, 1 g/kg) caused a dose-related reduction (16.2, 42.1 e 70.2%) of acetic acid-induced abdominal writhing while HE and DME (1 g/kg, p.o.) were ineffective. In the hot plate test, ME (300 mg/kg, p.o.) increased the latency of heat stimulus between 30 and 120 min and inhibited the first (45%) and second (60%) phases of nociception in the formalin test. The antinociception induced by ME or positive control fentanyl (150 µg/kg, s.c.) in hot plate and formalin tests was prevented by naloxone (3 mg/kg, s.c.). When submitted to the carrageenan-induced peritonitis test, ME (0.5, 1.0, 2.0 g/kg, p.o.) impaired leukocyte migration into the peritoneal cavity by 46.8, 59.4 and 64.8% respectively, while positive control dexamethasone (2 mg/kg, s.c.), inhibited leukocyte migration by 71.1%. These results indicate that the antinociception obtained after oral administration of methanol extract of M. lindleyana involves anti-inflammatory mechanisms accompanied with opioid-like activity which could explain the use of the specie for pain and inflammatory diseases. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-02 |
dc.date.accessioned.fl_str_mv |
2013-06-03T13:13:51Z |
dc.date.available.fl_str_mv |
2013-06-03T13:13:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
VANDERLINDE, Frederico A., et al. Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, p. 150-156, jan./fev. 2012, Epub 14 out. 2011. Disponível em: <http://www.scielo.br/pdf/rbfar/v22n1/aop18511.pdf>. Acesso em: 29 maio 2013. <http://dx.doi.org/10.1590/S0102-695X2011005000190>. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufpa.br/jspui/handle/2011/3944 |
dc.identifier.issn.none.fl_str_mv |
0102-695X |
identifier_str_mv |
VANDERLINDE, Frederico A., et al. Anti-inflammatory and opioid-like activities in methanol extract of Mikania lindleyana, sucuriju. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, p. 150-156, jan./fev. 2012, Epub 14 out. 2011. Disponível em: <http://www.scielo.br/pdf/rbfar/v22n1/aop18511.pdf>. Acesso em: 29 maio 2013. <http://dx.doi.org/10.1590/S0102-695X2011005000190>. 0102-695X |
url |
http://repositorio.ufpa.br/jspui/handle/2011/3944 |
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eng |
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eng |
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openAccess |
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