Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia.

Detalhes bibliográficos
Autor(a) principal: Londero, Marina Dalla Barba
Data de Publicação: 2021
Outros Autores: Hasse-Sousa, Mathias, Petry-Perin, Carolina, Claudino, Felipe Cesar de Almeida, Czepielewski, Letícia Sanguinetti, Gama, Clarissa Severino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/105254
Resumo: For years, the management of schizophrenia has represented a challenge for clinicians, with antipsychotic treatments usually resulting in relapses and new hospitalizations. Clozapine has been shown to be an effective medication for treatment-resistant schizophrenia (TRS), but is currently underused due to its potential side effects. Nevertheless, research has suggested that clozapine reduces future hospitalizations in patients with TRS. This study aims to verify the rates of hospitalizations in patients with TRS under long-term use of clozapine. We retrospectively analyzed clinical data from 52 individuals with TRS before and after the use of clozapine. The mean duration of treatment with and without clozapine was 6.6 (± 3.9) and 8.5 years (± 6.6), respectively. Patients had a median of 0.5 (0.74) hospitalizations per year before the use of clozapine and 0 (0.74) hospitalizations after it (p = 0.001). Therefore, the use of clozapine resulted in an expected reduction in the number of hospitalizations per year in individuals with TRS.
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spelling Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia.SchizophreniaTreatment-resistantClozapineHospitalizationFor years, the management of schizophrenia has represented a challenge for clinicians, with antipsychotic treatments usually resulting in relapses and new hospitalizations. Clozapine has been shown to be an effective medication for treatment-resistant schizophrenia (TRS), but is currently underused due to its potential side effects. Nevertheless, research has suggested that clozapine reduces future hospitalizations in patients with TRS. This study aims to verify the rates of hospitalizations in patients with TRS under long-term use of clozapine. We retrospectively analyzed clinical data from 52 individuals with TRS before and after the use of clozapine. The mean duration of treatment with and without clozapine was 6.6 (± 3.9) and 8.5 years (± 6.6), respectively. Patients had a median of 0.5 (0.74) hospitalizations per year before the use of clozapine and 0 (0.74) hospitalizations after it (p = 0.001). Therefore, the use of clozapine resulted in an expected reduction in the number of hospitalizations per year in individuals with TRS.HCPA/FAMED/UFRGS2021-07-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Articleapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/105254Clinical & Biomedical Research; Vol. 41 No. 2 (2021): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 41 n. 2 (2021): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/105254/pdfCopyright (c) 2021 Clinical and Biomedical Researchinfo:eu-repo/semantics/openAccessLondero, Marina Dalla BarbaHasse-Sousa, MathiasPetry-Perin, CarolinaClaudino, Felipe Cesar de AlmeidaCzepielewski, Letícia SanguinettiGama, Clarissa Severino2024-01-19T14:20:16Zoai:seer.ufrgs.br:article/105254Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:20:16Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia.
title Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia.
spellingShingle Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia.
Londero, Marina Dalla Barba
Schizophrenia
Treatment-resistant
Clozapine
Hospitalization
title_short Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia.
title_full Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia.
title_fullStr Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia.
title_full_unstemmed Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia.
title_sort Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia.
author Londero, Marina Dalla Barba
author_facet Londero, Marina Dalla Barba
Hasse-Sousa, Mathias
Petry-Perin, Carolina
Claudino, Felipe Cesar de Almeida
Czepielewski, Letícia Sanguinetti
Gama, Clarissa Severino
author_role author
author2 Hasse-Sousa, Mathias
Petry-Perin, Carolina
Claudino, Felipe Cesar de Almeida
Czepielewski, Letícia Sanguinetti
Gama, Clarissa Severino
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Londero, Marina Dalla Barba
Hasse-Sousa, Mathias
Petry-Perin, Carolina
Claudino, Felipe Cesar de Almeida
Czepielewski, Letícia Sanguinetti
Gama, Clarissa Severino
dc.subject.por.fl_str_mv Schizophrenia
Treatment-resistant
Clozapine
Hospitalization
topic Schizophrenia
Treatment-resistant
Clozapine
Hospitalization
description For years, the management of schizophrenia has represented a challenge for clinicians, with antipsychotic treatments usually resulting in relapses and new hospitalizations. Clozapine has been shown to be an effective medication for treatment-resistant schizophrenia (TRS), but is currently underused due to its potential side effects. Nevertheless, research has suggested that clozapine reduces future hospitalizations in patients with TRS. This study aims to verify the rates of hospitalizations in patients with TRS under long-term use of clozapine. We retrospectively analyzed clinical data from 52 individuals with TRS before and after the use of clozapine. The mean duration of treatment with and without clozapine was 6.6 (± 3.9) and 8.5 years (± 6.6), respectively. Patients had a median of 0.5 (0.74) hospitalizations per year before the use of clozapine and 0 (0.74) hospitalizations after it (p = 0.001). Therefore, the use of clozapine resulted in an expected reduction in the number of hospitalizations per year in individuals with TRS.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-26
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/105254
url https://seer.ufrgs.br/index.php/hcpa/article/view/105254
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/105254/pdf
dc.rights.driver.fl_str_mv Copyright (c) 2021 Clinical and Biomedical Research
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Clinical and Biomedical Research
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 41 No. 2 (2021): Clinical and Biomedical Research
Clinical and Biomedical Research; v. 41 n. 2 (2021): Clinical and Biomedical Research
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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